This is very interesting finding - till now most of the articles said/assimed that if P53 is activated - it will control tumor - does not seem to be the case. This could mean - K could be effective for some type of cancers as single agent and as combo therapy.
Other point - the articles mentions that there are P53 activatirs available - We have not seen any drug that is identified as P53 activator - Nutlins came close but with toxicity - not made major progress yet