NanoViricides Inc (NNVC)

[drkazmd65]

I just have to state,.... I find this whole argument quite amusing,....

any thoughts on "the shape of the virus is not as defined and symmetrical as other viruses, so the attachment points may not be as effective" regarding the Ebola virus?

Ha!

The 3-D shape of the virus on a macro-scale (if the term macro-scale can be applied to something as small as a virus) does not change any of the following facts.

1) The virus particles themselves are made up of a limited number coat proteins (one primary), arrayed in an extremely regular helical pattern along the length of that virus particle. At any one point along the length of that virus coat it looks just like the surface of any other part of that virus particle coat.

2) The binding protein(s) along the length of that virus particle outside of the protein coat are evenly distributed as well arrayed in an extremely regular helical pattern along the outside length of that virus particle. At any one point along the length of that virus particle it looks just like the surface of any other part of that virus particle.

3) The chemistry involved in binding between the ligands that NNVC has designed and bonded to the PEG component of their drug candidate(s) and the target proteins on the outside of an individual virus particle does not change depending on where on the outside of that virus particle the target protein is located.

4) The virus particles themselves are actually very symmetrical along their length - forming a helical tube, presenting the same targets along most of, if not all of, its length - regardless of whether that tube containing the viral nucleic acid is a bit floppy.


Because of these factors - the binding between an Ebolacide candidate drug and a virus particle should not be altered along the length of that virus particle.

Also - since the scale of the interactions between individual ligands and target proteins on the viral surface is orders of magnitude smaller than the overall length of the virus - the twist & turns along that length do not change the binding.


Amusing though to watch this yarn spin out.