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Re: BonelessCat post# 78656

Tuesday, 11/18/2014 1:47:54 AM

Tuesday, November 18, 2014 1:47:54 AM

Post# of 405212
BK would you agree that no matter the mechanism for P21 increase if Kevetrin is found to result in a dose dependent increase in P21 expression in these patients there is a very good chance that human studies will follow results seen with xenograph preclinical work. As P21 levels increase tumor response and regression should result. Any thoughts on HDAC inhibitors causing P21 expression and whether Kevetrin may be working through that pathway.
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