Yep, really complicated and they have to get it right. And that's why Leo said:
The latest data from the Kevetrin trial is on par with our expectations all along, suggesting Kevetrin is capable of activating p53. We believe we are nearing the conclusion of this first Kevetrin trial, but we still have some decisions to make, which could include another cohort to confirm our findings on Kevetrin and assist in planning for future studies.