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Re: BonelessCat post# 75390

Sunday, 10/26/2014 11:58:18 AM

Sunday, October 26, 2014 11:58:18 AM

Post# of 405218
As a general rule I enjoy ambiguity. In this case I find it annoying because because I have seven figures riding on it.

But I digress.

At the risk of murdering a fine point, something generally best left to others...the primary endpoint definition is ambiguous at best.

If it means that EVERY PATIENT must show 20%+ lesion reduction in under 3 days, then I am surprised any drug would ever meet that tough of a standard. Yet this is the literal interpretation of the protocol.

If it means that THE AVERAGE lesion reduction must be 20%+, then it leaves way too much room for wiggling. For example, one way to achieve average lesion reduction of 20% is for 20% of the patients to show 100% reduction and 80% to show nothing at all.

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One other point...No patients required "rescue" treatment. That in itself in a very significant outcome.

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