Remember Alios? They’re among the companies with an HCV nuke in preclinical development: http://finance.yahoo.com/news/alios-biopharma-announces-upcoming-rsv-120000004.html Presentation: Preclinical Characterization of AL-335, a Potent Uridine Based Nucleotide Polymerase Inhibitor for the Treatment of Chronic Hepatitis C Alios is the company from whom VRTX licensed a pair of preclinical nukes in 2011 (#msg-64166913); both of them failed.