ARIA: Looks like Cortez gave up 30mg for 1st line CML chronic phase, trying accelerated phase now: The goal of this clinical research study is to learn if ponatinib can help to control CML in accelerated phase. Inclusion Criteria: Diagnosis of Ph-positive (by cytogenetics or FISH) or Bcr-ABL-positive (by PCR) CML with accelerated phase features at the time of diagnosis. http://clinicaltrials.gov/show/NCT01570868