Nice post. I can only speak for myself, but I've not been able to convince myself to hold a core position for over a year. It just seems too prudent to start building it here and now. The low volume hold around 1.70 has shown great resiliency, and as long as things start to rapidly progress on the drug front, eventually having 2-4 millions shares traded a week will snap in and this will run to $4-5 in a hurry.
It seems to take forever to happen, but then it happens so fast once it does.