Avid Bioservices Inc (CDMO)

[biopharm]

the bottom line, Dmitry is the MD talking MDSC's and MDSC's "CAN" predict overall survival

its funny how its been KOL Dmitry Gabrilovich, whom continues to directly relate how MDSC's is the hidden link to support that surrogate endpoint of overall survival and Bristol Myers Squibb had prior ties already moving in this direction ...

MDSC-based Blood Test for Predicting Response to Cancer Therapy Commercialized by Serametrix

Nov 19, 2013

The test was developed at New York’s Memorial Sloan-Kettering Cancer Center under the direction of Drs. Jedd Wolchok and Alex Lesokhin.

http://www.serametrix.com/Press-Releases/mdsc-blood-test.html

... and Dr. Jedd Wolchock has been a longtime direct tie to BMS...

http://cancerimmunolres.aacrjournals.org/content/early/2014/06/30/2326-6066.CIR-14-0013.abstract

Memorial Sloan Kettering Researchers Report on Major Advances in the Treatment of Metastatic Eye and Skin Melanoma

June 3, 2013

“We pursued the ipilimumab and nivolumab combination because they each impact the immune system in a distinct but complementary way,” says Dr. Wolchok. “Ipilimumab activates a person’s immune system, prompting their T cells to begin attacking the tumor, while nivolumab further activates those T cells in a different manner, allowing them to continue the attack.”

Previous studies had shown that ipilimumab alone could prolong overall survival in advanced melanoma patients, and nivolumab alone could produce durable tumor responses in melanoma and other cancers. Combining the drugs was “quite logical,” Dr. Wolchok adds, and well supported by preclinical and clinical trial data.

http://www.mskcc.org/blog/msk-researchers-report-major-advances-treatment-metastatic-eye-and-skin-melanoma

I wonder how Vaccinations will work out with Bavituximab and PS Targeting..... which possibly are clearly improving the MDSC's..etc and bloodwork that Dr. Jedd Wolchok must be aware of....

Endogenous and Exogenous Vaccination in the
Context of Immunologic Checkpoint Blockade

Dr. Jedd Wolchok

Disclosure
• Consultant: Bristol-Myers Squibb

http://www.sitcancer.org/meetings/am10/presentations/index.php?filename=Wolchok_AM10_secure.pdf

The purpse of this post is simply to show Dr. Jedd Wolchok clearly already knows of the importance of MDSC's and how it can be used as a surrogate endpoint that links to overall survival..... just as Peregrine KOL Dmitry Gabrilovich is in the middle of clearly showing. Further... Dr Jedd Wolchok seen with his ties to "Serametrix" out of San Diego and bloodwork to check for MDSC's ....

Bloodtests for overall MDSC's or subparts..etc are coming and how long before its going to be announced is the question?