Avid Bioservices Inc (CDMO)

[biopharm]

Dmitry Gabrilovich : Peregrine Pharmaceuticals KOL :

I believe Dmitry is playing a major role in solidifying the changes that take place regarding our immune systems and most likely this will all play a part in some blood test to test for cancer in general due to many changes... some involving white blood cells aka = leucocytes (which there are 5 types)

1) Neutrophils
2) Eosinophils
3) Basophils
4) Monocytes
5) Lymphocytes - just will expand on this for now..

Two main types of lymphocytes are B-cells and T-cells. B-cells are characterized by the presence of immunoglobulins on their surface, and upon stimulation with antigen, they are transformed into plasma cells. Plasma cells are then able to secrete antibodies specific to the antigen. T-cells take part in cell mediated immune response, which does not depend on the presence of circulating antibodies.

http://bme.virginia.edu/ley/leukocytes.html

older post... been harping on these leucocytes/blood test for a while now...

http://investorshub.advfn.com/boards/read_msg.aspx?message_id=94362010&txt2find=leucocytes

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The JAK-STAT pathway is evolutionarily conserved, from slime molds and worms to mammals (but not fungi or plants). Disrupted or dysregulated JAK-STAT functionality (which is usually by inherited or acquired genetic defects) can result in immune deficiency syndromes and cancers.

en.wikipedia.org/wiki/JAK-STAT_signaling_pathway

... one of Dmitry's latest publications in 2014, and just sounds like some further connections are being made and reinforced, for that blood test to appear before us one of these days....

10. COX-1 derived thromboxane A2 plays an essential role in early B cell development via regulation of JAK/STAT5 signaling in mouse.

????: Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China;
??: Qiong Yang;Maohua Shi;Yujun Shen;Yingjiao Cao;Shengkai Zuo;Caojian Zuo;Hui Zhang;Dmitry I Gabrilovich;Ying Yu;Jie Zhou

??: Blood. 2014?

Cyclooxygenases (COXs) and their prostanoid products play important roles in a diverse range of physiological processes, including in the immune system. Here, we provide evidence that COX-1 is an essential regulator in early stages of B cell development. COX-1-deficient mice displayed systematic reduction in total B cells, which was attributed to the arrest of early B cell development from pro-B to pre-B stage. We further demonstrated that this defect was mediated through down-regulation of the Janus kinase/signal transducer and activator of transcription 5 (JAK/STAT5) signaling and its target genes, including Pax5, in COX-1(-/-) mice. Mechanistic studies revealed that COX-1 derived thromboxane A2 (TxA2) could regulate JAK3/STAT5 signaling through cAMP-PKA pathway, via binding with its receptor-TP. Administration of TP agonist could rescue the defective B cell development and JAK/STAT5 signaling activity in COX-1-deficient mice. Moreover, administration of low-dose aspirin caused a significant reduction in total B cells in peripheral blood of healthy human volunteers, coincidentally with reduced TxA2 production and downregulation of JAK/STAT5 signaling. Taken together, our results demonstrate that COX-1 derived TxA2 plays a critical role in the stage transition of early B cell development through regulation of JAK/STAT5 signaling, and indicate potential immune-suppressive effect of low-dose aspirin in human.

http://www.chinajypx.cn/Archive/Search?q=Blood[journal]