Biotech Values

[aslan2772]

ALNY Liver/systemic delivery.

Dew, I don't know enough about the liver to comment meaningfully. I can say though, that Alnylam has demonstrated uptake of their "morpholinos" (with systemic administration in rodents) in several tissues other than liver, but not the brain. It's probably mostly systemic, but like most drugs, it may have tissue distribution biases, difficulty crossing the BBB or entering the prostate, etc.