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Re: genisi post# 178905

Friday, 06/06/2014 9:45:25 AM

Friday, June 06, 2014 9:45:25 AM

Post# of 257262

MRK—In addition to the higher dose, note they are using "reformulated" raltegravir this time.

Indeed. Giving a the cumulative daily dose of a BID drug all at once is not likely to work well in terms of safety/tolerability; giving 50% more than that amount all at once is even less likely to work. Clearly, the new formulation of Isentress has a sustained-release mechanism.

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