It wouldn't seem logical to expect efficacy to increase with lowering the dose. I agree. Still, it is possible that somehow there is a beneficial relationship between lower AE's and improved efficacy. Have a look at Chart 15 of the ASCO .ppt showing that appears to indicate for CCyR, Iclusig durability improved, albeit modestly, with lower dosing. I'm just saying, it may be worth a look for Rida.