MDSC's effecting human disease is an interesting theory, but no where near proven in human diseases.
If it ends up to be proven DG should receive the Nobel Prize.
Myeloid derived suppressor cells (MDSC) have been described as a heterogeneous cell population with potent immune suppressor function in mice. Limited data are available on MDSC in human diseases. Interpretation of these data is complicated by the fact that different markers have been used to analyze human MDSC subtypes in various clinical settings.
Outlook
MDSC have gained a lot of attention in recent years mainly in the tumor immunology community. However, based on the results from murine studies in non-tumor settings, human MDSC will need to be analyzed in more detail in non-cancer patients as well. One major hurdle remains the heterogeneity of the cells. The only possibility of overcoming this problem will be through a thorough phenotypical and functional analysis of all potential MDSC subsets in different clinical settings. Identification of better markers will facilitate these studies. More in-depth analysis of the interaction of MDSC with other cell types will help understand the biological function and, finally, the specific targeting of human MDSC and their subtypes will help the effect of immune-based therapies in cancer.
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