Triple 000 and Sub-penny Chart Plays

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hello trader53. i follow u daily. i have two questions for you. i definitely understand about taking profits but i am in a stock VGPR that i believe will go higher. i bought at 0.0003 so i've come a long way. am i being a putz by holding on. it seems to be a great company.
Also, i see you stated that high a/s in the billions was okay. how about high short interest? i was looking at OPMG and it had 43k in short interest. does that matter in your calculations? thanks for your inspiration and guidance.