At physiological pH, the head groups of PtdSer and PtdIns have an overall negative charge
Ok.... sometimes I have some crazy ideas from shares being transitioned over the past 18 months to some Big Pharma in secret meetings trying to mitigate their demise to all sorts of stuff...
but I'm sitting here tossing the basketball around and walking over to find a magnet buried under some dirt and what do I think? you have it... thinking of PS ! lol
more than a few articles I come across mentioning that PS is "negatively" charged... so that means a PS targeting agent must be "positively charged" ???
Now I am thinking of the difference between natural dying cells where PS targeting does not interfere with so it must not be "negatively charged"... right? maybe so ???
Back to basketball... summer is here and negatives and positives and energy and hmmmmm...
"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical pipeline." -- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!