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DVAX: Can't find any specific news to account for PM drop and current rise.
You?
I'm wondering if the Admins know which iHub board has the highest number of bans, and if so, what that number is?
I'm not asking for the specific board name, though I've got one in mind; to me it indicates either an exceptionally large amount of persistently offensive posters, or a very thin-skinned mod.
CEO..... gives a very god presentation of the clinical design enhancements.
And claims everything is His creation.
FWIW I would suggest that what you are missing is that it is human nature to look at inventions made by others and say 'that's obvious' (and therefore clearly not worthy of protection) - a classic example is the concept of zero. And another is the concept of sound=vibration. And yet they are both reasonably recent discoveries.
Do drug companies conduct their time-consuming and expensive product development activities for the good of humankind or to make money? I’m going with money.
Unless the USSC decides to disagree with Jefferson’s well-known sentiment—“Society may give an exclusive right to the profits arising from them, as an encouragement to men to pursue ideas”—they’re going to uphold patent rights.
DVAX: I'm guessing that the company has been communicating/negotiating with the FDA since the ADCOM meeting. There's a decent chance of Heplisav approval for high-risk patients, where the acknowledged overwhelming efficacy is more important than any possible safety concerns. Additionally, as a condition of approval, Dynavax would have to collect data and conduct additional trials.
While the $10+ predictions are out the window, at least for the near future, I can easily see this at $5 by the end of February, which makes it a pretty good buy right now.
All IMHO, FWIW. Best of luck to all.
DVAX: From a Seeking Alpha blog:
http://seekingalpha.com/article/1012961-dynavax-crashes-on-unexpected-panel-vote
some panel members raised issues that, while not directly related to safety (that is, directly to adverse effects issues), spoke more to their desire for more safety data. Specifically, those who voted 'no' on safety wanted a large (10,000 patient) data base developed comprised of patients with more ethnic diversity and, as well, involved the co-administration of Heplisav with other adult vaccines.
It's unfortunate one or more panel members did not have the presence of mind to 'educate' their fellow panel members on trial conduct and statistical analysis (though one member did attempt to do this, as did the DVAX personnel present). That fact is, as was argued, even if the size of the populations used in the Phase 3 trial had been doubled or tripled, it was highly unlikely that events falling outside the safety envelope would have been detected[Bolding mine].
If FDA has final say, i wonder when this go for their review. I hope it's soon.
DVAX: To echo AF's tweet, "What the hell just happened at the DVAX panel?"
I'm surprised and disappointed. Wondering how safe does safe have to be, and does the current ADCOM system tend to be overly, unreasonably cautious. Not sure if some of these panels would OK aspirin or penicillin.
I am on one heck of a losing streak!
A tie is a loss (i.e. status quo), as far as I know.
When there is a tie vote in the Supreme Court the Court simply announces that the Court is evenly divided and affirms the lower court decision which is under review. The decision has no precedential value; the affirmance is issued to afford finality for the litigants in that particular case.
How on earth did 25% of Egyptians get infected? Is there some other mode of transmission there than blood?
Endemicity
Egypt has a very high prevalence of HCV and a high morbidity and mortality from chronic liver disease, cirrhosis, and hepatocellular carcinoma. Approximately 20% of Egyptian blood donors are anti-HCV positive. Egypt has higher rates of HCV than neighboring countries as well as other countries in the world with comparable socioeconomic conditions and hygienic standards for invasive medical, dental, or paramedical procedures. The strong homogeneity of HCV subtypes found in Egypt (mostly 4a) suggests an epidemic spread of HCV. Since a history of injection treatment has been implicated as a risk factor for HCV, a prime candidate to explain the high prevalence of HCV in Egypt is the past practice of parenteral therapy for schistosomiasis. The large reservoir of chronic HCV infection established in the course of these campaigns remains likely to be responsible for the high prevalence of HCV morbidity and may be largely responsible for the continued endemic transmission of HCV in Egypt today
OT: In the biotech analysis field, you two guys are the greatest one-two punch since MacNeil & Lehrer, Siskel & Ebert, Orville & Wilbur.
(I will not say Laurel & Hardy because it could be misconstrued.)
I'm conservative about these sort of price projections (guesses!) for stocks in any sector, much less the unpredictable and often bizarre world of biotech: I'm looking for $5.50, $6 max.
Best of luck to all.
OT:
That’s a good explanation—lawyers do not come cheap.
TSRX has a larger company partner in Bayer for Asia. Believe they still want to keep U.S. rights while ultimately finding a partner for the EU.
Re DVAX: They have an FDA advisory committee meeting on Thursday; they will or will not recommend approval. Actual FDA decision in February.
The briefing documents for the advisory committee will be released today.
IMO the market is waiting for those docs. Then, the ADCOM rec. Then, the actual approval.
If all are positive (and I agree with you, they should be) there could be a PPS rise with each step.
For me, the moral of the PYMX story is that antibiotic development requires larger companies.
...this screwup may be even more costlier.
Could your grammar be even more funnier?
Interesting article on Ebola in the November Smithsonian:
http://www.smithsonianmag.com/science-nature/The-Hunt-for-Ebola-174938951.html
From the article:
None of the virus hunters had any expectation that a vaccine against Ebola was imminent. The drug development process takes an average of 15 years and costs billions of dollars. Pharmaceutical companies are reluctant to expend those resources to combat a virus that has killed about 1,080 people in 30 years or so. So far, nearly all Ebola vaccine research has been funded by the U.S. government to combat potential bioterrorist attacks. The Army Medical Research Institute of Infectious Diseases in Fort Detrick, Maryland, recently tested an experimental vaccine made from virus-like particles on guinea pigs and monkeys, and reported promising results. Several biodefense contractors have initiated small-scale safety trials with human volunteers, who are not exposed to the Ebola virus. But most virologists say that an effective vaccine is many years away.
On CNN just now, Utah congressman Chaffetz saying, "Republicans are right on principles, they just don't do a very good job of communicating."
ROTFLMAO.
What I'd really like to see are mandatory, non-volunteer based nominations of Donald Trump as Ambassador to North Korea and Sarah Palin as Ambassador to Somalia.
Both would be hog-tied by Navy Seals, then put on planes and forced to parachute in at night (preferably naked, but I don't want to be mean and unreasonable about it.)
My personal choice would be Powell, who truly is an example of something almost extinct: a moderate Republican. Obama would be reaching across the aisle but not just to score points, he'd be getting someone who would genuinely do a good job.
Along that line, Richard Lugar also comes to mind.
I agree, we'll see, a long time in the future.
For now, let's see if absent of the nagging, ever-present, rather repressive re-election concern our man can put the pedal to the metal and really get something done!
Arizona: your Rachel Maddow list of facts is probably the best and funniest and truest thing I've seen today. If I could afford it I'd print up a huge copy and put it in my front yard.
Arizona- I posted before reading your post: exactly what I'm saying in my message, it's going to be more and more about youth and the non-traditional.
I love and admire Hillary, but she just won't cut it in 2016.
Warren is 63 and will be 67 in four years; Hillary is 65 and will be 69 in four years.
They're both my contemporaries and while I don't consider myself old (just eccentric and cranky) many if not most of the future lifeblood of the Democratic party—younger, non-traditional, non-white voters—would view Elizabeth, Hillary and me as downright ancient, if not prehistoric.
We’re going to have to come up with a much younger candidate, but also one with enough political experience and personal power to avoid the obvious charge of inexperience.
Look at the Republicans, you see that they’re beginning to realize that just another old, rich white guy probably will no longer fly, that’s why Rubio is being mentioned so frequently.
While my underlying attitude has been, is, and always will be "Fuck 'em", instead of merely arguing as I did when younger I now have more fun teasing them, provoking them, and annoying them.
My wife says that it's my main hobby.
For many reasons I have to strongly disagree with the notion that Hillary will run in 2016. I think there's a strong likelihood of a woman candidate, but my gut tells me it's going to be someone almost completely off the current national radar.
Heidi Heitkamp?
Noticed in my mainly Republican neighborhood today: an obvious refusal (beyond mere laziness) to take down Romney/Ryan signs, and even more interesting, a marked proliferation of empty chairs.
My take on their message: we will not even consider working together, we're going to continue to be as actively counter-productive as possible for the next four years, we still think that bastard's a Kenyan Muslim Socialist, we're proud to be stubborn and stupid.
Oh well.
TSRX: Been averaging down the past couple of weeks as the price steadily drops.
Just wondering, besides the general market conditions, the election, the price of tea in China, etc., has there been any specific negative news that I might have missed?
TIA.
This market will be violtile till the end of the year
I agree with what PGS was alluding to earlier: while as a society we no longer think it's acceptable or funny to make spastic or retard jokes, fat jokes are still just fine.
The only problem: obesity isn't funny (and it's expensive!)
Borealis:
I'm a lifelong liberal Democrat, and like you overjoyed with the President’s win, but taking a realistic look at the popular vote and the map of the states, we both can see that it was not a landslide.
I’m very much afraid that the traditional concept of the loyal opposition has ended: our side lost, now let’s roll up our sleeves and work together for the common good. What we’re going to see is increased polarization, increased destructive foot-dragging and nay-saying, increased obstructionism.
I’m happy that we narrowly avoided the insanity of jumping right back to the very people who caused this mess, but we need some sort of mass societal recognition that the only sane path is cooperation.
Gary
Congrats to all the fine people here.
This shows that our nation has not totally lost its collective mind and that some degree of rational sanity remains.
I don't know for how much longer--and I remain pessimistic about it--but for today we're good!
Very good, I believe you, that's just what I wanted to hear!
Thanks much.
I am just wondering that if they had an inkling that the company was being pursued or had any interest in being acquired at that time, why would they have pulled the trigger on 6 million shares?
Thanks much.
I'm specifically talking about iHub. Although I'm a Premium member, I didn't realize that since I didn't automatically renew, the no-ads feature was not grandfathered in, and this year's renewal will include ads, unless one wants to pay the ridiculous fee of $300 per year!
Unless you post otherwise, I'll assume that Adblock Plus will work on iHub (by any chance, do you or any other boardmembers have any personal experience with this?)
...Kessler sits on the board and Symphony just dumped 6 mil shares.
I'm sure that this has been asked countless times in the past year, a link to a relevant post would be fine:
Do the various ad-blocking programs really work to block the iHub ads? What's the best one/some good ones?
TIA.
Hyster-Yale Materials Handling makes the kind of products that you often see but seldom notice. Its forklifts are ubiquitous on construction sites, factory floors and in warehouses, but if you don't spend much time around these places, Hyster's name—and its shares—are invisible.
THESE DUMPS WE BEEN SEEING IS PURE DILUATION
Maybe it's an instituation selling?
Re DVAX: This could be absolutely nothing--just routine boilerplate--or it could be important, but they filed a form 8-K after market close: an amended management continuity and severance agreement for J. Tyler Martin, the president and CMO.
http://biz.yahoo.com/e/121102/dvax8-k.
The focus seems to be that if he was terminated without cause, including a change of control, he would receive all his benefits.
Preparation for an upcoming buyout?
Just started a position this week, best of luck to all.