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Getting better and I have to jump on a conference call... dammit
Not going well yet......
It's on......
That's one of those "it depends"......... if you ask the supplier how much IPE they can produce in X amount of time, and you just received FDA approval for your medicine that reduces the risk of the #1 cause of death on the planet, it is not unreasonable to say, I will buy all the IPE you can produce.
Totally agree JRoon
Hey Zip..... yes it would be interesting but it would also be problematic........ humans have eaten meat throughout our evolution...... monkeys, although they have many similarities to humans, are not meat eaters........ that's why studies are so challenging....... one of the earliest studies and a major foundation of the cholestorl causes heart disease.......In 1913, a study by a Russian pathologist, Nikolay Anichkov showed that rabbits fed on cholesterol developed lesions in their arteries similar to atherosclerosis, suggesting a role for cholesterol in atherogenesis. Duh! So the obvious major flaw in this widely accepted study by the medical community is that rabbits don't naturally eat food full of cholesterol........ it makes me laugh how these people who are so smart lack common sense. Feed a human the diet of a rabbit and see what that causes.
See, you are already demonstrating bias by saying it's trying to encourage cancer growth. It's actually trying to show that eating red meat does or does not cause cancer. It would be very easy to find 500 people to go on a Carnivore diet for 30 years if you were going to provide the meat or highly subsidize it. 499 more as I'd volunteer.
Why would it be unethical?
Well JRoon, the fact that humans have been cooking red meat at high temperatures on an open flame for 1 million years. If that caused cancer, we'd be extinct. Any studies on red meat causes cancer, are observational studies...... not good science..... it's one of those extraordinary claims without extraordinary evidence. So until there is a randomized controlled blinded study showing this, it's just a theory.
Ha..... the only long term problem I see with a Carnivore or low carb lifestyle is called "old age". We shall see as I'm willing to be a lab rat for others to use as a test case
Nice Princess Bride reference........
JRoon........ show me the double blind placebo controlled study showing fruits, vegetables, and nut don't cause heart disease They never did that study..... all kidding aside, you're right....it's all the junk carbs. Fruit's, vegetables, and nuts cause veganism and vitamin B deficiency
So true ORBAPU......... the elephant in the room (pun intended) is the worlds fixation on the reduction or elimination of animal meats and fats to be replaced by garbage seed oils, nuts and plants. All in the name of lowering cholesterol. Prior to the AHA war on cholesterol, 1 in 10 Americans had heart related illnesses......now it's 1 in 3. As Capt'n would say......"It's the Shitty Diet Stupid"
That's great Sleven......... I don't recall but we don't have France reimbursement yet, correct?
Kiwi, I hope you are correct.....it does run in my family though on my fathers side although they did a lot of drinking and smoking....... father and his 3 brothers died of heart related issues. Bad lifestyle choices. His only sister had a bad stroke and she was a sweetheart.
LDL of 20? You need to get that up .
I'm not saying LDL isn't something to be concerned about if you are metabolically unhealthy. It is....... it's a factor but it's not THE factor. CVD is the number one killer in the world..... yet although statins have been around for a very long time, CVD is still the number one killer in the world. My point is that if you are metabolically healthy and you have a high LDL, your Dr will suggest that you take a statin to get your LDL down. I will test this next month. Prior to going on this very very low carb way of eating that I have been doing for 5 months now, my LDL was around 105 and my HDL was around 90. My trigs are around 40 so you can argue that I am pretty healthy metabolically. My BP tends to hang around 130/85 ish.... sometimes just above 140/90 but usually below that threshold. I eat mostly protein and healthy fats so next month I will have my lipids done to see where they stand. I suspect my LDL is going up and I'm curious to see what my General Practitioner has to say. I'm 6'3" with 18% body fat so pretty lean...... it's possible that my LDL goes way up on this way of eating so stay tuned.
Good info ORBAPU
Kiwi, that's the problem with so many cardiologists and GP's today...... they still think LDL is the big boogyman. They are old school and I'd say a bit lazy at times.... LDL isn't even a cholesterol...... it's a lipo-protein that carries cholesterol throughout the body to all the cells that need it. Without LDL, you die. It's when it gets damaged is the problem and that happens primarily via the crappy lifestyle choices people make through diet and lack of exercise. As many on the board are saying....... V works regardless of your LDL which is another example of LDL has an association but is not the cause of cardiovascular disease. Just like fireman seem to be around fires all the time. They are associated with the fire but not the cause
The Chargers have a ton of talent and continue to be underachievers ........ like this damn stock of ours.
If we can show a benefit to bio-markers....... imagine the possibilities...... not only to health and well being of humanity but my bank account....
https://www.yahoo.com/news/6-9-million-americans-alzheimers-091040764.html
BP = Big Pharma
I find this to be interesting...... "It should be noted that a healthy growth in the sales volumes of our existing products was partly offset by pricing pressures on some of our key products, such as Icosapent Ethyl Capsules and Vasopressin."
North, you qualify for amazing.......keep on doing whatever you are doing and may the rest of us maintain our level of mental acuity (whatever that may be ) as long....
Another potential indication could be creatively marketed as a longevity drug. If you decrease CVD events, you live longer. Seems simple enough
https://www.yahoo.com/finance/news/cheap-generic-drug-became-darling-140517326.html
Sage advice my friend........... Kyler Murray is a happy dude right now and has asked AD not to return
Thanks DMC....... I'm starting to feel better already just knowing there's hope for my condition. Although Bourbon is still an option.
Does V work for depression? Is it Bourbon soluble?
Nukem...... this is even worse for me....... every Rams opponent is now sipping on a Bourbon.
https://www.yahoo.com/sports/aaron-donald-3-time-defensive-player-of-the-year-announces-retirement-to-end-10-year-nfl-career-161616800.html
Hi Capt'n............. I seem to eat humble pie every day I'm invested in AMRN
Thanks Sleven.......... I hope someday AMRN comes out with some sort of press release and plan for this. I guess they are waiting on the actual issuance of the patents perhaps before they announce anything...... they drive me crazy...... once the share price hits $100, I'm out!
Maybe it's my peabrain not being able to remember but did AMRN ever state that we definitely have marketing rights to MND-2119 in the US and/or anywhere else excluding Japan?
Nukem, you are into self inflicting pain I see........ I bought 2k shares of Apple stock back when the Lisa computer (precursor to the iMac) came out......it was probably at $2/sh........ I refuse to do the math and figure out how many times it has split since then and what it would be worth today. It would just piss me off more. And if any you of you care about my blood pressure, don't go doing the math for me either..... let it go!
Hey, it worked for Hillary...... don't delete your texts..... she just had everyone delete their texts and smash their cell phones. Nothing to see here. That makes him smart..... not a dumbass.
Nice find............... here's where it's THE EPA STUPID needs to be communicated loudly again. I am astounded by the fact that they cite the Jellis study which did not use a placebo yet with a smaller EPA dose had significant CVD benefits...... then they cite the REDUCE-IT study which had a larger dose of EPA yet the reasons for the differences in the EPA group and EPA+DHA group are unclear. Where do these people go to school? On Sesame Street? With all due respect to Sesame Street of course.
"Results from the Japan EPA Lipid Intervention Study in 2007 supported the growing body of evidence that LC omega-3s reduce the risk of heart disease, especially in people with a history of coronary artery disease [56]. In this study, 18,645 people with hypercholesterolemia (total cholesterol of at least 251 mg/dL) with or without coronary artery disease received either 1.8 g/day EPA plus a statin or a statin only. After a mean of 4.6 years, the EPA group had 19% fewer major coronary events than the control group. The EPA group also experienced a significant reduction in rates of unstable angina and nonfatal coronary events but not in rates of sudden cardiac death or coronary death in comparison with the control group.
In an analysis of the primary prevention subgroup from this study (participants with no history of coronary artery disease), EPA supplementation had no significant effects on any outcome. However, for the secondary prevention subgroup (those with a history of coronary artery disease), the EPA group had a 28% reduction in the rate of unstable angina and a 19% reduction in that of major coronary events. A separate analysis of data from this study found that the EPA supplementation did not affect total stroke incidence but did reduce the risk of recurrent stroke by 20% in patients who had previously experienced a stroke [57]."
"However, both the REDUCE-IT and STRENGTH studies used similar doses of omega-3s (4 g/day) but reported significant CVD benefit in the former and none in the latter. The reasons for the different results are not clear, but a partial explanation—beyond differences in the omega-3 formulation (ethyl ester EPA vs. carboxylic acid EPA and DHA) and the baseline health of the study population—may lie with the different placebo comparators used, mineral oil in REDUCE-IT and corn oil in STRENGTH [64,73,74]. Mineral oil is not a neutral placebo; it affects lipid levels and inflammatory markers and may inhibit the absorption of statin drugs. Therefore, in REDUCE-IT, differences in CVD events between the treatment and placebo groups would likely be smaller if a more neutral placebo oil had been used."
Yes...... so does normal aging so people need to stay on top of it...... crappy diets and a sedentary lifestyle will result in the need to change your diet so either get busy living or get busy dying (Shawshank Redemption ref).
JRoon, no worries.....I agree that V will benefit those who are on their way to developing atherosclerosis.... I was just pushing back on this statement below about science pretty much proving those that eat mostly red meat will suffer serious heart disease. You actually have half of it right. The fact that the variations of those diets help people lose weight and keep them from eating processed junk and sugar, is what will dramatically reduce their chances of having CVD issues. So if you really dig into the science that associates the red meat with heart disease, you will find it's very flawed and founded on flawed studies. Unlike Reduce-It which was a very robust study.
"Yes, the carnivore diet and other no-carb diet variations help people lose weight and keep them from eating processed junk and sugar. But science pretty much proves out that many will eventually suffer serious heart disease as a result."
JRoon...... you could not be more wrong..... science has not shown anything of the sort.....there are competing studies all the time and you have to ask yourself, who sponsored the studies? Reduce-It was a double blind, placebo controlled study that was peer reviewed and punched and poked..... that is a study you can believe and trust and that is the only kind of study you can trust.
I agree but it won't be due to people on the "carnivore" diet. We eat all meats not just red meats. My Trigs are 40 and HDL is 90. It's all of the insulin resistant folks that are dealing with blood sugar issues and diabetes due to diet and now trying Wegovy and Ozempic..... wait until they start experiencing the long term effects of those drugs.
You need not worry Triple88......... CVD is not going away anytime soon.... it's only getting worse. You have our global ministries of health always pushing the outdated food pyramid and advocating less meats and saturated fats and more grains, nuts, fruits, and vegetables....... couple that with the majority of people live a sedentary lifestyle and it's no wonder Cardiovasular Disease is the number one killer in the world...... V is safe and very very unknown at this time.......... we need some advertising that states....... taking V while also taking a statin with proper diet and moderate exercise has been shown to promote weight loss. It's one of those 'duh, that's obvious" statements but people are so dumb these days, they jump on anything that says weight loss.
Let them buyback 100M shares....... I'd be fine with that for sure........ let's get the damn authorization in place and start buying.