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A birdie chirped in my ear and it sounded like “not for long…chirp”
And that is more truthful than all the false narratives being pulled out of so many dark places… maybe, or would that be “short” sighted commentary?
Was it John Wayne in a western movie giving the all clear call - wagons ho !!!
Magrit, thanks and let’s both make an effort to get better sleep tonight. Sunday night will probably be more tempting to turn into an all nighter !
And all you other folks please get your mind out of the gutter - we’re talking nwbo here ! (I confess, while started innocently I couldn’t help going for the double entendre )
You, you…,you, you’re good
I’m recovering from the nwbo anticipation lack of sleep as well so I know exactly what you mean.
It would be lovely to have Madonna’s autograph and more so to meet her of course. Ya never know…
Don’t know if she does or is even aware, and who would fault her for having her focus on many other things, however if you do invite her to visit and she becomes aware of the struggle and promise against GBM, it wouldn’t surprise me if she would be moved by it.
But this is beyond projection and assumption and is totally baseless and only serves amusement, maybe?
(I amuse you? I’m funny? How, like a clown? - flow of consciousness or worse)
It’s going the other way, isn’t it?
Seems like there are fewer posts about the daily share price movements and a lot more posts about macro.
It’s widely well understood now that the daily share price can be moved by “influences” such as those highlighted in the case being brought against the MM/hedgies (and ultimately expanding to mercenary affiliates of the cabal.)
So more of the posts are dealing with events, catalysts, RESULTS, and other relevant info, imo.
Don’t know whether the Biden admin is aware yet, however they have a great opportunity to get behind, and of course take some credit for, the potentially broad breakthrough platform of Dcvax and combo treatments across solid tumor cancers -
Can you say Moonshot? I knew you could!
Biden especially has the closest of ties to GBM, which DCVax L immediately is a victory (both personally for Biden I would think, and politically.)
And also imminently the amazingly great promise that DCVax-PD1 is indicating, and which could be in practice very quickly especially with admin support.
Then at the same time the moonshot umbrella can facilitate multiple parallel studies and trials across the most needed cancers or as many as could be pursued.
This could transform, at least for immunotherapy and DCVax in particular, a more serial attack on cancer into a geometrically expanding attack!!!
Maybe too much caffeine today?
The handle came about when I first joined the ihub nwbo message board, way before reading all the terrific due diligence and wisdom shared on the board.
It was either blind luck or very lucky premonition/thinking or both, the horse representing DCVax and the CarT representing adjuvant combos, which I wasn’t enlightened enough to even know the meaning of adjuvant at the time.
But again guessing/intuition that DCVax weaponizing the immune system against the patient’s tumor, prior to CarT (which I thought is the same or similar to CI - are they, I still don’t know?) aiding the immune system (like the eat me/don’t eat me switch that another biotech I believe from Canada (Telluride??) of the time was pursuing and got bought out by BP later for) to help find and attack the tumor cells.
Also a bit of premonition is the inference that progress would take determined step by step moving forward pulling the payload cart behind it.
Now one could take it sickening further by analogy to the horse focusing ahead with blinders and not getting spooked by threats along the way…. Ad nauseum, if you’re not already there
Obviously retirement can result in too much idle time and a lot of storytelling
Madonna had moved to Portugal (true)
A thought - any professionally run software development and support team must use a source control system to make any changes and deploy new versions.
Testing is done prior to deploying new changes as part of the process.
So intentional code changes history should be available.
However I would imagine it would be really brazen, stupid, and untenable by the technical employees to knowingly take part in such questionable activities as to code the spoofing or other algorithms. Not that you can’t find or corrupt a techie, but less likely and not smart to in effect corrupt a whole IT team.
This logic gets back to setting parameters and/or manually initiated trading patterns being more likely if one were to engage in such alleged activities. This gets back to people deciding when to use and how much effect is targeted (decision making and implementation of such decisions, hypothetically speaking) and “pushing the buttons to drive towards the targets.”
So it gets back to what got executed and what/who drove it.
This has all been just an idle thought exercise and nothing more, and irrelevant and uninformed versus real forensic teams investigating real alleged activities.
No worries however I appreciate your message !
Maybe get enough of them to form the Bunkettes
Yes, decades ago I had business in Chicago and stayed by the northern loop by the waterway and big newspaper building. Great unique architecture, including in the hotel we stayed at, with a huge spiral up/down walkway in the middle of it.
Ooops, I did it again
Thanks for setting me straight.
I found JJ listed as a 10% owner and under the insider umbrella on a stock website I landed on.
Thank you!
Chicago again, I won’t utter a word
All you say about Chicago is valid, however I don’t know that there isn’t gravy on top by being in a state that might offer a friendlier environment in legal/prosecutorial situations. If nothing else it’s a quick short flight or boat ride to certain islands and Central American locals
Obviously I don’t know this as a fact, far from it, just a thought. Epstein received some favorable treatment in Florida. And yes, that’s another one off example and doesn’t indict the state.
But look, you’re right to call me out for unsubstantiated comments even if it was stated as a feeling.
A lot of what I post has been intended as entertainment while we wait for the next great catalysts to come. It’s a coping mechanism. Once in a while I post substance or answer a question.
Do you mind me asking at what point will you stand up and fight for this brilliant woman against the fake journalists trying to tarnish her work?
— Linda Powers Alter Ego (@_NWBO_) December 10, 2022
No, JJ is an insider by virtue of being on the BOD and he holds a large interest in nwbo, second only to LP I believe.
At least that’s the info I saw on the web.
He is not an nwbo employee if that’s what you mean.
Yes, that was the reported reason, of too much crime in Chicago.
Lately I’m wondering if it has anything to do with blue state red state differences that might come in handy in a tight spot.
Seems like a few shady dealing characters have been attracted to Florida (and a whole lot of innocent law abiding folks too.)
Pardon my ignorance, but who is Chris Jordan?
And LG has been extremely quiet and unseen lately, fwiw.
Very cogent points!
I salute your concise way of bringing our attention to the direction of the tide instead of focusing on individual white caps in the wind of change.
Is that knowledge gained from a new specialized institution of higher learning?
I’m speaking of What’s aMatter U !
They best not mess around with dna from TRex and AF…. Ohhh the horror!!!
Really? I don’t think so. What’s the problem?
The simple truth is shown by a very simple table:
SOC at 5 years. 0 alive
SOC+Optune @5yrs. 0-2? Alive
DcvaxL @5yrs. Approx 60 Alive
DcvaxL+pd1 @5yrs approx 60% Alive no progression
Who’s on first… I don’t know - third base !
Tommy Lee for VP of Investor Relations!
Imagine the ASMs he would plan and the regular drum beat of PRs
Just biding the time until the next real great news is released!
Got all mine too and voted them for mgt recommendations
Just in time for the new Adult Happy Meal
When one has the secret sauce that either enables or enhances the efficacy of N checkpoint inhibitors/pd1/PDL1 of a blockbuster nature, and possibly other combo adjuvant candidates what can you do?
Either you play kingmaker with one perhaps of each type of adjuvant, foregoing the other N-1 candidates and their potential combo sales (and becoming a target for legal and antitrust attacks)
Or
Set up for multiple partnerships and thus enable the most parallel advancements and relationships, accomplishing more for advancing the fight across different cancers, encouraging the competition among the combo candidates to trial and improve the efficacy of their combo treatments, and transforming nwbo (or resulting entity owning the DCVax platform) from a target to be destroyed into a necessary partner that enables a candidate combo to succeed and incentivizing each partner to be at least as good or better than the competitors for an indication.
So, imo creating some type of multiple partnerships and/or licensing arrangement would be in our and the industry’s and especially the patients best interests. I think this would remove DCVax from being an endangered species, at least until some better breakthrough should be discovered.
Of course since the skeleton crew (and mature ones) at nwbo is presently not staffed to do the heavy lifting, the arrangement needs to address that either by allocation of responsibilities and costs, or by the surviving DCVax platform entity structurally adapting.
First, I believe it was some 28 thousand plus C shares at an equivalent common share price of 85 cents per share (1 C = 25 common) for a total price paid of $600K to nwbo.
Jerry has been an outside director of nwbo for a number of years, and he already had a large insider interest in nwbo, second to LP’s holdings.
One can speculate that Jerry investing that much of his money to buy C shares serves a few purposes. First, the money paid for the C shares is paid directly to nwbo and is fully available to nwbo to use which is important to nwbo to keep the lights on.
Second, Jerry’s stake in nwbo is increased and thus his share of success or failure. Maybe Jerry thinks differently but I wouldn’t risk that much more of my cash unless I was pretty confident of success.
Third, it puts more voting shares into friendly hands, although I’m not sure if Jerry would qualify for voting for this ASM due to requirement to be shareholder of record as of __?
So the insider buy is positive.
Some view a negative by thinking Jerry wouldn’t be allowed to make this purchase if he had material non public information such as a partnership or buyout. I’m not sure about how the actual constraints and conditions would play out and which catalysts, etc.
PM may shed some light on this possibility tonight?
Isn’t a $600k insider buy a good sign?
Jerry already is way up there in insider ownership and he bought C shares with his own money?
Using a person’s tumor to arm his/her immune system to search and destroy the tumor is so natural and elegant of an approach, and the checkpoint inhibitor unmasks the tumor disguised as benign cells.
I’m always struck by the marvelous and powerful system of systems our bodies are!
The point of the slide is that combination treatments including DCVax and PD1/PDL1 appear to promise better efficacy than either alone, with remarkable long term survival/cure response rates!!!
It wasn’t just from the phase3 which she quickly stated as 25. She took some time gathering thoughts and numbers across the other trials and treatment groups.
As best as I could comprehend it seemed like about 50 or more long term survivors still alive who had received DCVax.
The early combo treatment big fat tail is indicating > 55% Long term survivors AND if I heard it correctly it is without progression!
Not enough Chianti and fava beans in the world for even Hannibal to have AF for dinner
Sorry, cheap shot at AF, shouldn’t stoop to that level, right? Slurp, slurp, slurp
You know, I barely slept last night and with all this anticipation I doubt I’ll be snoring tonight!
At least I won’t be getting elbow checked repeatedly by my spouse tonight. Sometimes I get up feeling like a mugging victim! Good thing she doesn’t play golf
Throw away the park bench and the golf clubs, welcome home for good, big!
There is no such thing as a “dumb question,” right?