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This stock will always tank at some point, until it doesnt. Im willing to wait, we have time on our side.
Man, over time, we have all been beaten down so bad. a Rise like this would have made all the social media platforms explode, now we are all Charlie Browned out. One of these days.....
me either
I want my money back the shorter chat room advice was wrong
I really enjoyed this chart Friday helped me go long and make a lot of money! Hope thd shorters didn't ask for their money bavk!
The company hasnt issued a PR yet...
Myn guess is the next PR includes the BO from Shire, Takeda, or Pfizer.
Fry shorts you certainly deserve it@!
As another Father, wishing you great strength and praying your son gets better.
I follow them and did not receive anything
IMO he has been muzzled by his masters, either due to a BP looking at partnering up, or due to scrutiny by the SEC, and the major arrest this week in NY of a large group of brokers ( Platinum Investments) that were scamming a lot of money out of investors.
His silence was, on balance, outstanding.
When he does comment now, he insults retail investors, but doesnt talk poorly of the data. He has been gelded.
Waited a LONG time for this. Hope all the shorts get obliterated. Good times for us longs congrats!
Still love all your posts Xena, also appreciated your warning as it were, to leave names out of posts, so as to have the good stuff not get deleted.
Just wish there was a way that we could keep purposely destructive FUD off the board thats all. Seems to be back with a vengeance,
Falconer also fervently wish you would crossover to our FB groups NO bashing and in depth discussion about the very same materials you excel at. Please consider it.
Again my apologies Tom
I think a lot of folks, myself included, were having a knee jerk reaction, to the Bad Olde Days, when so much opportunistic FUD was being tossed around, with the intentions of freaking out weak hands, to give up their shares.
Not an excuse, but an explanation.
So to shift the topic forward, I am not quite sure why the concept of this financing, is considered apparently by so many as a third rail?
Yes, I see you did. Thank you Tom, my error, apologies.
This can all easilly be solved, with a paste and copy from anavex customer relations.....first person to get the scoop please just post the letter thank you.
http://www.marketwatch.com/story/two-traders-arrested-over-alleged-manipulation-of-more-than-2000-stocks-2016-12-12
Hope these two made some money off of AVXL so everyone else has to lay low...
hey, you could easily be right, Im just relaying some words of someone I know who is pretty smart, no worries M.
hes not bashing adaptive design, he is bashing the use of a cognitive endpoint in a pre clinical population, as an interm analysis measure.
BTW I have no idea what that means, my friend is in the business. The man in question, is on the advisory board for AVXL and also works with the other companies you mention. And these are the words of my friend, all Im good to talk about is how Brady is the GOAT.
Funny thing is my friend is in Big Pharma, and is very...not skeptical, Id say reserved. And is the first to point out any AND every possible thing wrong or negative about...everything.
He read thru all the slides, I asked SO, what do you think.
He said
Its good.
From HIM that was screaming from the rooftops YES!!
I was actually shocked.
Its good.
Comment from a friend...
Maybe LLY and BIIB should buy print shops.
A scientific friend of mine replies: It is NOT avxls presentation, it is Mcfarlanes presentation, and he is legally obligated to make these disclosures.
11:45 EST I believe...
Blind Squirrel, Nut. I got lucky. Thank you :)
Coffee, CTAD is a very private affair, and charges 1200 or so a ticket, to create a "special" congregation of Experts. They do NOT allow webcasts, as this would allow the Hoi Polloi to view the same said materials, at the same time, as the exalted ones :) My best guess is the second the meeting starts or the second AVXL finishes their presentation, soup to nuts, will be on their AVXL website
So Adam Frankenstein is willfully admitting that he has seen the embargoed data for CTAD, and is implying, that the great news we heard today, is NOT representative of what the data will show on saturday.....so by extension, the data will not be good? How is any of this legal? How is this not blatant manipulation to try to affect the market? How come he is allowed to be alive?
He is the master of collecting pennies!
ABSTRACT
Abstract
OC60: 9-MONTHS AND 12-MONTHS SAFETY AND EXPLORATORY EFFICACY DATA OF ANAVEX 2-73 IN A PHASE 2A STUDY IN MILD-TO-MODERATE ALZHEIMER’S DISEASE PATIENTS. Stephen Macfarlane1, Marco Cecchi2, Paul Maruff3, Kristina M Kapiak4, Christopher U Missling4 ((1) Caulfield Hospital, Melbourne, Australia; (2) Neuronetrix, Louisville, KY, USA; (3) Cogstate Ltd., Melbourne, Australia; (4)
Anavex Life Sciences Corp., New York, NY, USA)
Background: ANAVEX 2-73, a selective sigma-1 and muscarinic receptor agonist was tested in a Phase 2a study in patients with mild-to-moderate AD. Adverse Events (AEs) were recorded for assessment of safety and maximum tolerated dose (MTD), the Primary Endpoint of the study. Cognitive (MMSE, Cogstate, QEEG/ERP) and the functional (ADCS-ADL) marker were measured so as to establish a functional relationship between dosing regimen and exploratory efficacy outcomes, the Secondary Endpoint.
Methods: Thirty-two AD patients 55-85 years old with MMSE between 16 and 28 were recruited. After establishing the MTD and dose response in PART A of the trial, in PART B, all patients received ANAVEX 2-73 between 10mg and 50mg daily orally and re-assessed at 12, 26, 36, 48 weeks. For safety and MTD determination, mathematical modeling was fitted to the recorded AEs to establish the dose-risk relationship. For efficacy, statistical hypothesis tests were performed on cognitive and functional markers.
These functional markers were compared to the corresponding baselines.
Results: Safety: ANAVEX 2-73 demonstrated a favorable safety profile when administered to a clinical population of elderly AD patients with varying degrees of physical fragility. The most common side effects across all AE categories tended to be of mild severity grade 1, and were resolved with dose reductions that were anticipated within the adaptive design of the study protocol. Positive unexpected therapeutic response events, such as improved mood, improved social engagement and increased independent activities were recorded.
Exploratory Efficacy: 9-months and 12-months data of all available patients demonstrate that ANAVEX 2-73 preserves average MMSE and ADCS-ADL (PART B) scores across the entire patient group. ANAVEX 2-73 continues to show benefits over baseline for both Cogstate and QEEG/ERP.Conclusions: The safety of ANAVEX 2-73 was assessed and MTD was determined. Despite not optimal dosing in the longitudinal PART B of the study, both cognitive and functional performance is sustained over at least 9 months, suggesting that the effect of the compound does not seem to worsen AD symptoms with repeated dosing. In a disease state where progression is invariable over time, a stable MMSE and ADCS-ADL score is considered a positive outcome.
Population pharmacokinetic analysis is currently ongoing. The data collected so far support further clinical development of ANAVEX 2-73 and preparation for a larger confirmatory study is underway.
Ok, help me out here. I have never had a stock be delisted. Can some veterans on the board give a honest view of any pros and cons that could apply to us? I had a different stock, that got LISTED and it was looked at as a tremendous thing, to get taken seriously, and ultimately, to be able to be attractive to institutions. Thanks
Correct. People registered have the info already, if they reveal it, they are in deep doo doo.
Saying That Crap Trader is a parasite spammer, who collects the crap that fish reject from the bottom of the ocean. He CAUSES nothing, in the same manner ambulance chasing lawyers don't CAUSE the accident
If you want to start your day with a bang and a smile.google Charlie Sheen, and Cytodyne, so many publications, and newspapers are covering the story this weekend....
LOVE seeing news like this. Cmon Charlie be your usual loud mouth self get to talking...
Wish I had heard of this, up 70% today. Oh Well.
His posts have no impact, anyone can post childish graphs about any stock that just went up 3 days in a row and us due a trace back.
News out....
Man Stockaesthete I love when you do that!~
Great News!!!
News out!! CDC contract!
Stockaesthetics is as genuine and easy to chat with as they come. Ferociously intelligent, a tremendous asset, having great experience in the halls of both the scientific and the practical applications of Big Pharma. I hope she keeps contributing.