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Thanks Dude D:
No doubt about the pollution they belch out..the stuff they burn isn't the bottom of the barrel, it's much thicker.
I live along the coast and on a calm day the shipping lane is demarked by their brown smoke if there's much ship traffic.
The problem i see is that there's no way to enforce pollution controls on ships registered to token ports/nations aside from refusing to let them into our territorial waters...That'd cause shipping interests to scream real loud.
HDW: as always, it comes down to clinical trial results and FDA approval.
All the rest is noise.
Next week would do.
Hi Easy:
We are in a race against many other companies as well as watching vast numbers of innocent folks agonizingly dying of cancers our constructs might cure. Time elapsed is critical.
We have an aging technology in a fast moving field and i have no idea what of our IP protection remains.
We have 20 some constructs, most of which remain untried.
Clinical trials start cheap but become wildly expensive by the time we get to ph 3. We should have all our constructs advancing through early stage trials. That should have begun years ago!
Money is the problem here and we are moving forward glacially. The FDA isn't the main obstacle presently because we have not advanced our clinical trials far enough to submit the results by in large.
Having been in this holding a fair number of years, i'd point out that we've been anticipating significant BP deals "very soon" all along the way...Finally we have one, along with some grants and institutional support.
Perhaps both being a cancer survivor and having had too much of my portfolio bound down in this so-far-unprofitable stock for many years...Affects my perspective.
All along it's been clear that the potential is there, but remains mostly un actualized.
HDW:
We've waited so long and endured so much...It'd be a damn shame to get bought out before we can cash in the enormous potential inherent in ADXS.
Sudn:
Both candidates have come out excessive prices for drugs.
It's populist issue and it's going to effect us all because of some greedy, exploitive companies like Shrikelli's and like Milan with the epipen.
There's good justification for charging to cover the cost of development of a new drug like the ones we are working on.
But epinephrin has been a widely available generic for many years and the injector in the epipens is no big deal. That sort of unjustifiable price gouging is going to take the drug industry down big time if we don't straighten up.
Imagine standing before the voters and saying you are going to deny some poor little girl who suddenly can't breathe with allergic anaphylaxis ,an ordinarily cheap drug because her single mom can't afford the jacked up price.
What senator is going to stand up for the drug company in an election year?
SIGH!!
At least we are still afloat.
It's amazing that we can demonstrate a 30% survival rate in cervical cancer but still be on our economic knees with most of our constructs untested.
Management shouldn't be maneuvering to optimize trader profits!
We have a bunch of clinical trials to fund, and taking advantage of a bump in PPS to bank a few more bucks is what we ought to be doing.
Down under $6 and sinking..In light of the distribution, it sure is cheap.
Gonna buy a bit more and enjoy a little income.
The corn and soy market may be down now, but in the long run, folks gotta eat.
Just picked up the shares i sold when it last peaked....about 1/4 of the total.
Not normally a trader, but like a fish finally hitting a yoyo-ed lure,
I bit, again.
It's going to be a long time before we see any ph 3 trial results and the PPS will probably keep bouncing till then.
Sure wish we had a significant R&D effort going. Just knowing why there are non responders would be very helpful. As would a more satisfying substantiation of the mechanism of action....etc.
As i recall, they had previously lead us to believe we'd see study results sooner, more than once.
Mayo, this isn't a transparent company. They release data in a fairly unpredictable manner and one has to suspect their motivations...In light of last time.
That made me kinda queasy in terms of their honesty with the stockholders...Saving the somewhat disappointing news to the very last.
I own too much avxl to be comfortable with that.
PLEX, the stock will move when we have some solid clinical trial results.
If we can damp the hype, the SOC is so modest that if our ALZ Ph 3 results are equivalent to the ph 2 results...We are a shoe-in!
While all the promising other indications have real allure...It's our ALZ application that needs to be pressed forward , first and foremost!
If we do shift focus now..we will be in the position of serially floating juicy promises to successive ranks of desperate folks in a manner that suggests abhorrent quackery and gives me the willies!
We already spend twice as much on administration, legal and employee stock compensation than R&D...And i can't help but be uncomfortable with that.
Please, lets focus our funds and talent on the PH 3 trial and prove we have something real!
I keep thinking that PETA ought to be funding these studies.
It's ironic..Pied Piper in reverse with the mice leading the hopeful humans.
We owe a huge debt to the mice for all the diseases we can treat that began with mouse tests.
Of course mice and folks are quite different and what works for them doesn't necessarily work for us....It's a hint though.
I don't think XON's future is in Zika prevention.
First, Wolbachia bacterial control is advancing nicely,
Second, scientists say that the zika spread is near it's peak and will decline probably.
Third, the public hysteria about "Frankenskeeters" makes general release politically uphill.
4th . the cost is prohibitive for all but wealthy areas.
XON is a sprawling and diverse company working on a number of promising arenas and that' good enough for me.
We'll see double digits when PH 3 clinical trials report and are approved .
It'll be a yoyo till then
Other countries have banned shorting quite successfully. Just a question of political will.
Lets toss in high frequency trading while we are at it.
Then fully fund the SEC and place draconian legal barriers between them and financial company influence.
I sure hope you are right Kettleman. I've had $ in both for a long time .
What i see finally is indications CLNE will survive, and that's all we need till the price of oil recovers and our cost advantage becomes inescapable.
I'm sweating WPRT's survival still.
Wiser than i....Waiting for $3 to come around again next oil price dip.
But it wasn't fun at all riding out the long decline.
Well, that didn't last long..Predictable.
I see bounces with attendant slides like this and wonder if i shouldn't be trading?
Just going to hunker down and wait for the long term trial results.
Easy; if admin thought we were about to release "huge news", they wouldn't have done the $13.50 deal.
Acquisition? Please.
We can't actualize the promising constructs we already have.
We badly need more productive focus and less vague future promises.
A sequencing machine or 2 of different types, sure, then rely on publicly available databases perhaps..But buying a company that'd have enough processed data is a bigger bite than we can afford, i'd guess.
$8 now...A leak or rumor RE the long term trial results?
Lorema..it only matters to traders. I think this is a bet for the long haul.
thanks Due!
Is this rise all because of that one contriarian article?
It was underpriced because of the pipeline, but that's mostly years from fruition..And that leaves the long term trial results that were regarded as a longshot, given the short term failure.
Thanks Due..That's convincing.
Legally and politically it's going to be an uphill battle.
But if the environmentally cognizant nations ban such ships from their waters, things ought to shift fast.
I wonder how NG compares with bunker oil per BTU for cost?
The engines on those ships are staggeringly large..You could camp out in each cylinder space quite comfortably...Must be enormously expensive to build.
I wonder if conversion is even possible?
That bunker oil is so thick they have to heat it to pump it.
We agree Karin.
It's disconcerting as a lifelong allergy sufferer.
But it was the drying effect i was after, in part.
It was a retrospective study, as i recall. So not difinitive.
They may indeed as well as general cognitive diminution but the study was retrospective and hardly definitive...as i recall.
Benedril was such a solid standby for so long that millions may be affected.
Other than the insomnia mention in the little ALZ trial; is there evidence it's good for insomnia in regular folks?
There's a chance that might have showed up in the first safety and dosing study
The early antihistamines are effective cheap and non addictive...So is pot and booze...grin
Good fer you!
I've been in it much longer and am not up much over all..Not a trader.
It's also possible that there is some negative PR yet to be released and we are getting while the getting is good. To be expected sooner or later.
We should be setting up and funding clinical trials on all our solid constructs ASAP. That should have happened years ago.
Clinical trials are extremely expensive, but if successful, increase our value and bargaining position dramatically. Recently read that clinical trials for a cancer drug runs about 300 million bucks. We can't even fund one yet.
Once we get a successful drug or 2 on the market, then we can fund the rest.
Meanwhile, other companies and researchers are working furiously on the same problems with advanced techniques, knowledge and instrumentation, and our big lead is fast vanishing.
Because advanced clinical trials are staggeringly expensive and we have 20 some constructs that need to be tested ASAP
Respectfully; save that for when we have an FDA approved cancer drug on the market and are cash flow positive.
Now we are strong like a promising calf still in the cow's womb...
But soon....
Hi Suden:
Like you, i've been imprudently overcommitted here for years.
But i'd rudely point out that my expectations have repeatedly gone unfulfilled.
I keep assuming that in the long run we are really going to flourish, but i'm getting kinda old for such unrequited optimism.
I've found that projecting dates for future events here is very frustrating and time linked expectation is something of a trap.
But, sooner or later......grin.
Sure am delighted we are finally free of the SEC inquiry albatross.