I can't know for certain why that incident stopped them, but it did. Nobody called the police that night, but they knew they could have been arrested since they came onto my folks property. Of course I could have been fined for littering. Maybe they became drunk with power over the years as they became more and more outrageous and nobody did anything about it, as their group grew larger and larger, and this slap in the face sobered them. Or maybe they just didn't realize what a nuisance they had become and it took something radical to wake them up. Some people might guess that they had not had any fathering or proper fathering and they were begging for guidance. "Searching for boundaries.".

Not sure myself. I think their sobering-up to the damage they were doing was the biggest part with their legal predicament being second.

But... one of their gang had told the gang that I was nothing to worry about. That guy was a thorn in my side from an early age, even after I finally boxed him at about age 12 to shut him up. That boxing match, with gloves, lasted about 5 seconds. One punch to his solar plexus and he was toast. I didn't win the fight that night with the lead biker, but I did throw him to his back from standing at one point with a pretty nice upper body move, though I couldn't hold him down for long. He did get in 10 smacks to my mouth when I was in a head-lock, but I got a take down and near fall! He knew after that while he could take me, I was not push-over. So he knew after that night that there were people out there that would stand up to him and could. And... the father that moved in was a pretty big dude. An HP Engineer... probably not someone that would go toe to toe, but this biker now knew he could not assume that.

I didn't give up in that fight even though I was being pummelled repeatedly in the mouth. The other bikers broke it up out of concern that the police might arrive soon.

Some mix of the above.

Thanks Ou. Back when I started on this board, nobody here knew about checkpoint functions. I think they are the fly in the ointment and the alleged long tail might represent the patients that do not have overexpressed checkpoint function.

I remember realizing about a year in that us early posters, including Flipper and John, were a second generation of posters. There was apparently a dark period where the first wave fell away through multiple reverse splits, before NWBO was able to re-emerge as a new miracle cure. Realizing that was a bummer. That said; if DCVax-L ultimately proves out... if that tail is real, then all that hating on LP should turn to admiration because all of our pain is nothing compared to the pain of the victims of GBM and other cancers, and their friends and family. Recall that LP lost her father and a sister to cancer, and that may have more to do with her tenacity than the infamy of her former employer.

For the record, that brief but nasty bout with the biker happened on my folks' property. The new neighbor's biker-(defacto)-gang had turned the very pleasant middle suburbia where I grew up during my wonder years into a hellish place for my folks during their retirement. The neighbor bikers were letting their two pit-bulls hang out on their front and side lawns, unleashed. My 77 year old mom tried to start taking walks but was chased onto her porch by the two pit bulls. The postman had filed a complaint about the dogs, but nothing was done. Those bikers had connections. I told my dad I was going to talk to them, but he asked me to not do that. Though nobody would guess it, my dad was a tough little guy (youngest major in the marine core in 1943 and did not go to a military academy), but he was nearly 80 years old, and I would not be there to protect him all the time. Then the bikers started having parties in their back-yard that ran until 2AM. Their house was on a corner, so their backyard faced the front of my folks side yard... the music blasted right into my folks bedroom window, frightening my mom and keeping her up late nights. They blasted many hundreds of Watts, maybe 700 Watts nor so, and with elevated speakers. After my folks moved out and put the house up for sale, I was there painting etc on the last night of prep for sale. I slept on the kitchen floor. Those neighbors were having one of those parties. At 9:15PM they set off a pack of firecrackers on the metal roof of a shed they had built in the back corner of their backyard. This was the corner closest to my folks and all the other neighbors and the metal roof was fence high. I finally got back to sleep when they set off another pack at 10:15PM. I would get all upset and debate going over there, but then eventually talk myself out of it and get back to sleep. But the same thing at 11:15PM, 12:15AM, and 1:15AM. After the pack at 1:15AM I did not calm back down. I remember my heart pounding out of my chest. I thought about those pit bulls and my mom, and about all the little kids in the neighborhood that the pit bulls might go off on. The people moving in had two little kids on top of that. And it wasn't fair to sell them the house knowing all these problems they would face... . I went out to deal with the situation and passed the large garbage cans on the side of the house on my way. Then I had a brilliant idea. I hefted the full garbage can up over the fence, shaking the contents out into the biker party. About 2 seconds later, their great leader, my dad's neighbor, jumped over the fence. I did not win that battle (ouch), but I won the war. They stopped letting their pit bulls out off leash, and they stopped having those parties. The people that bought the house never had to deal with any of that. I should add that while the inside of my mouth was a mess, and my new Levi's were shredded by the rose bushes we were amongst, there were no visible marks on me while that biker had a mouse under his eye. So I went in looking better and came out looking better, but mostly I stopped them from abusing the neighborhood that I had grown up in.

Full disclosure: I own as many NWBO long shares as I can afford, yet I am also short.

Thank you Vator.

Are direct shares preferred shares or some other class than common?

The president of IMUC quietly bailed out in the weeks before the bad news and nobody on message boards talked about it. Not saying this happened here... need to look at more SEC docs I suppose to be sure. If LP retained warrants or net moved things to warrants, then there is still good reason for hope. Even if she just flat out bailed, you are right that there is some hope, but scary situation.

Re: LP Holdings Vanilla Header not trying to make a stink but want to ask this to a believer and don't have messaging privileges: Why does the NAS say that LP sold the last of her shares in late 2018? Is this misleading or is there a common view/explanation here among longs? I know the NAS numbers for pink sheet stocks are often not accurate, but thought I would ask about this.

https://www.nasdaq.com/market-activity/stocks/nwbo/insider-activity

"DCVAX(R)-L", "DCVAX(R)-Direct". (R)?

Is any of that increase conversion of warrants?

What I meant to say is; if DCVax-L proves successful; at this point, I think you would have to give as much or more credit to Linda Powers as to Lynda Lau.

The title of the Slide is "Updated Unblinded DCVax-L Data" ...equivalent. And the date below says 2019. But as we all now know it was not updated data, but data from 2018. In fact, it was the same data presented at last year's SNO conference and possibly the same slide with the date on the bottom added.

I do not believe for a minute that was an accident. The only question is whether NWBIO intended for that image to be broadcast or just the person tweeting. Not an issue for the presentation probably where the fact that it is 1 year old+ data was probably explained, just an issue to tweet that deceptive image with no explanation that in fact it is year old data.

I remain hopeful that DCVax-L for GBM will prove out, and even more hopeful that DCVax-Direct + CI's will prove synergistic.

As for deceptive tweets; Since you rub shoulders with these big dogs, maybe you can find out for sure who posted that deceptive tweet and give them some grief. That is not ok.

Did they tell you to "Stay Tuned!"? Just asking, because that would be a sure sign that Top Line data is about to be released any day now.

Also... wondering, are you the one who posted that criminally deceptive tweet that showed a poster announcing "New Unblinded Data" for DCVax-L GBM with a 2019 date at the bottom? Just asking because the guys at the SEC may want to know.

I'm not saying this was presented this weekend. But if anything was presented, this was likely it. That tweet showing that poster was totally misleading, and that was almost certainly deliberate. Tweeter be damned.

Yes we have seen the poster title before: https://nwbio.com/updated-interim-data-from-phase-3-trial-of-dcvax-l-for-glioblastoma/

Impossible SAP-->ITT Stats?

Isn't the SAP here a bear due to the crossover? Maybe worse than a bear? Wouldn't that leave the ITT population to fall back on? If so, they may know exactly where they are.

Only true if no webcast. There is a webcast, so there can be news during the presentation.

I watched the takeover of Therasense by Abbot. Abbot first sent down a mid-level+ manager who got things in order, for about year, prior to acquisition. So while Duffy was not super senior at Merck, his level is consistent with the one takeover that I have witnessed up close.

Of course that doesn't mean that is what is going on here. Maybe iclight is right about the salary bump... but he is making a big assumption with no data.

I have to take the blame for this flurry of negativity. I overstated, out of ignorance, Duffy's former rank at Merck. Exwannabe was correcting me, which was the right thing to do, so as to not lead-on investors.

Not as important as I implied but more important than you make it sound. I stand corrected. He was not the head of the Ketruda program, but he was the head of an important part of it. He is a heavy hitter for sure and his presence is a very big deal for NW and some or all of it's programs.

You are correct Maverick,

Commenting on the reason behind the spike, not the spike itself. And of course the suitablily of Moly as a lubricant for your vehicles. Not sure if it is used during Alien probing, but hopefully that question will prove moot.

Holy$#&n Moly!

PDT and PST are the same thing as far as I know.

2:15 PDT. 2 hours difference not 3. https://savvytime.com/converter/cdt-to-pdt

Thank you Flipper: Just got off work. Will have to study this for a while.

Anyone: Datalock PR? When was that PR? I can't find it? The way I remember it, LP announced that they felt the trial had matured to the point that datalock was appropriate. She went on to say that it could take a very long time to finish the locking and then collecting and analyzing the data.

(As I recall) Flipper (traditionally one of the most if not the most positive honest person on the board) had recently felt burned by NWBIO on-goings and was critical of the claim that they would need a long time for data analysis, saying that the plan and algorithms would all have been in place long ago... Or am I hallucinating again? FMS False memory syndrome?

I hate being so wrong, but I was feeling guilty not saying anything. Of course I am net glad that I was wrong. The 100M preferred (approx 1B common equivalent as far as I know) was just shares authorized. As for what is outstanding for preferred, I don't understand the doc, but it is certainly a tiny fraction of the 100M. Not that such could not change overnight, as far as I know and based on a bad experience at an employer 30 years ago.

I still don't understand why the forced conversion of all outstanding preferred to common does not show in the 10Q, but it is not a huge issue.

Again, my apologies. I had been worried about it for months now and hadn't said anything. Thanks for ignoring me. Less bad karma that way.

I will be surprised if the OS estimate that you make is not surpassed (nearly) 3 fold as per the next 10Q that should include the count of preferred shares forced to common since the last 10Q.

I hope I am wrong. I have a hard time understanding the regulatory docs and I'm not sure if the number of preferred shares involved was listed as the common share equivalent or not. If so, then the dilution would only be about 100M shares common, and your estimate would be right. But my guess is that there will show a 1B share dilution to 1.51B or something like that.

I am still very hopeful for DCVax-L and Direct both, with CI's if not without. (Particularly hopeful for Direct with CI's which I think could be the marriage of the century).

I don't think this is what they meant, but the company, in their recent PR about the meeting said, "In controlled clinical trials, oliceridine demonstrated efficacy compared to placebo".

Tell me this is not what they meant. Please.

…. Oh... I read this as "efficacy comparable to placebo". compared to is better.

Patent: The way I remember it, Anavex was arguing that there was synergy shown for 2-73 with a very small amount of DZP or similar added. This very small level of dosing probably made any competition for the Sigma 1 Receptor a non issue. It would also make the cost of adding that very small dose of (now generic) DZP (or similar) a non-issue.

That was the final standoff... Anavex claiming this synergy at a very small dose of DZP... and then the patent was finally granted.

I think you will find this history in the "Image Wrapper File" or other records. https://portal.uspto.gov/pair/PublicPair

Significance of "Precision Medicine" is understated. In this proposed trial the advantage to the 20% of patients that will be left out is not just the ability to try other treatments. Being left out opens a market and thus an incentive, and thus cash for development of new treatments for that 20%. That is why this type of patient screening is not just smarter, but more ethical.

So how good are those scores? 80% is an enormous subgroup to go after, much larger than I thought they would go after, but how much improvement is what he is describing, and are those two measures enough to convince the FDA?

Either this is fantastic news and the big dark ominous powers are trying to keep AVXL sp down, or these results aren't significant. Is the quote not what it appears, or the man quoted not who they have painted him to be?

HTF can the sp be dropping if that quote is accurate and the guy quoted is who they say he is? Maybe really is Overstock.com syndrome (big evil dark forces manipulating share price).

Or maybe they are getting the funding out of the way early to allow for an uninterrupted stairway to heaven in the near future.

Not sure about skyrocketing, but I am anxious to hear what they have come up with for patient screening. They have not talked hard numbers in the past from my recollection. History says they will avoid it again, but I am hopeful. Alzheimer's is so huge that any significant subgroup is also huge. Further, not only does targeting improve their chances of success, it is the more ethical approach. It is just better, if it is not a random curve fit as some have warned.

PR legalities if data lock has been reached? I haven't been following the board lately. I am sure the subject has been discussed. Very interested in hearing the various views on this topic.

It would appear to me that they have now reached official trial maturity / data-lock / un-blinding / the primary endpoint. Of course that is not a certainty but the smell of such is all over the place.

If so... what are their PR legal responsibilities as a public company? I know they can't say wrong things... and maybe that means they can't say anything until they understand the data? Given the primary measure of efficacy was to be progression, and progression is a little debatable (though whether it is debatable is debatable) maybe they have to examine the data for quite a while to be sure what to say about progression, even if ignoring subgroups. Regarding survival, however, it would seem they would have to have a PR very soon, unless it being secondary puts it so far in the background that these laws don't apply. They could always give the survival results, even if bad, and say that subgroups are being analyzed to appease Matthew McConaughey, flipper, sentiment, cherry tree, etc.. and myself.

Not sure about tomorrow, but I do believe things are finally happening.

I decided not to post it because I don't want to give the publication the attention. Apparently it's his own publication at his own website.

I should correct my post. Adam isn't saying that Spain left the European Union, he is saying they left Europe. Apparently just got up and moved overnight. No reports yet on where they moved the country to. But I took the leap to assume they had to leave the EU if the left E.

If anyone has sighted Spain, please tell us about it.
************************************************************

"ADAM'S TAKE

Red flags fly over Anavex: What’s stopping the drug maker from enrolling U.S., European patients in trials?
By ADAM FEUERSTEIN @adamfeuerstein JULY 9, 2018

Anavex Life Sciences, a small drug maker in New York City, has committed publicly to an ambitious roster of clinical trials for its lead pipeline product Anavex 2-73, including trials in Alzheimer’s, Parkinson’s, and other serious neurological diseases.

But does Anavex have clearance from regulators in the U.S. and Europe to enroll patients in those Anavex trials?..."
************************************************************

Adam Feuerstein announces Spaxit, Spains overnight exit from the EU. In a shocking news article that will undoubtedly rock the world markets tomorrow, Adam Feuerstein claims to have exclusive inside information that Spain is no longer a member of the EU where data leading to drug approval in one member country can be used to support drug approval for all members.

At least Britain had the courtesy to announce their plans well in advance, while Spain apparently chose to wait until hours before their exit, and then tell only one man, Adam Feuerstein. Why Adam Feuerstein? Well Adam, often affectionately referred to as "Kramerstein's Monster" is a world renound expert on everything from beer to baseball to Brain Cancer to Parkinson disease, just ask him... all with only a BA in political science. A truly uniquely talented man; one of few at Martin Shkreli's level.

No $2.62 in the 8K. Not even in the complete submission text file. Where did you get that?

Re. enrollment. 2-73 had a big fan in that MD in charge of the clinic where they ran their studies. If he is still a fan, I would think he would be great help in speeding enrollment. As I recall, he was the top Psychiatrist in Australia for Alzheimer's. I don't remember reading in the PR whether they are going to only enroll genetic and otherwise identified suspected super-responders, but if so, that, of course would make enrollment more difficult. But again, they likely have the heaviest hitter in Australia assisting them in finding patients and talking clinics into participating.

US P3? Might want a partner. Could it be Biogen? As a cheerleader and long investor I believe it could be.

Makes total sense to do a study in Australia whether or not they do one in the US. And the study in Australia would be easier to setup and get approved, so would be announced first.

Doc Logic: There was much more wrong with my post. I could feel Pryo's face contort when I later realized how off I was. I was talking as if they were injecting the tumor proteins / lysate rather than the loaded DC's. I guess I'm rusty. Wish I could say I was drunk... but not the case. If anything like my worries does happen, it would be like this: Excess DC's (if any / as one person claimed) die and macrophages bloom/converge locally to eat them up. The macrophages would provoke inflammation response in the surrounding tissue... including raising the blockade flags. But this would likely just be local to the injection, not up in the brain. So... no way to rationalize my being that full of it. My bad. (I used to hate that saying but now that it is 20 years old I like it.)