Thanks Ou. Back when I started on this board, nobody here knew about checkpoint functions. I think they are the fly in the ointment and the alleged long tail might represent the patients that do not have overexpressed checkpoint function.
I remember realizing about a year in that us early posters, including Flipper and John, were a second generation of posters. There was apparently a dark period where the first wave fell away through multiple reverse splits, before NWBO was able to re-emerge as a new miracle cure. Realizing that was a bummer. That said; if DCVax-L ultimately proves out... if that tail is real, then all that hating on LP should turn to admiration because all of our pain is nothing compared to the pain of the victims of GBM and other cancers, and their friends and family. Recall that LP lost her father and a sister to cancer, and that may have more to do with her tenacity than the infamy of her former employer.
For the record, that brief but nasty bout with the biker happened on my folks' property. The new neighbor's biker-(defacto)-gang had turned the very pleasant middle suburbia where I grew up during my wonder years into a hellish place for my folks during their retirement. The neighbor bikers were letting their two pit-bulls hang out on their front and side lawns, unleashed. My 77 year old mom tried to start taking walks but was chased onto her porch by the two pit bulls. The postman had filed a complaint about the dogs, but nothing was done. Those bikers had connections. I told my dad I was going to talk to them, but he asked me to not do that. Though nobody would guess it, my dad was a tough little guy (youngest major in the marine core in 1943 and did not go to a military academy), but he was nearly 80 years old, and I would not be there to protect him all the time. Then the bikers started having parties in their back-yard that ran until 2AM. Their house was on a corner, so their backyard faced the front of my folks side yard... the music blasted right into my folks bedroom window, frightening my mom and keeping her up late nights. They blasted many hundreds of Watts, maybe 700 Watts nor so, and with elevated speakers. After my folks moved out and put the house up for sale, I was there painting etc on the last night of prep for sale. I slept on the kitchen floor. Those neighbors were having one of those parties. At 9:15PM they set off a pack of firecrackers on the metal roof of a shed they had built in the back corner of their backyard. This was the corner closest to my folks and all the other neighbors and the metal roof was fence high. I finally got back to sleep when they set off another pack at 10:15PM. I would get all upset and debate going over there, but then eventually talk myself out of it and get back to sleep. But the same thing at 11:15PM, 12:15AM, and 1:15AM. After the pack at 1:15AM I did not calm back down. I remember my heart pounding out of my chest. I thought about those pit bulls and my mom, and about all the little kids in the neighborhood that the pit bulls might go off on. The people moving in had two little kids on top of that. And it wasn't fair to sell them the house knowing all these problems they would face... . I went out to deal with the situation and passed the large garbage cans on the side of the house on my way. Then I had a brilliant idea. I hefted the full garbage can up over the fence, shaking the contents out into the biker party. About 2 seconds later, their great leader, my dad's neighbor, jumped over the fence. I did not win that battle (ouch), but I won the war. They stopped letting their pit bulls out off leash, and they stopped having those parties. The people that bought the house never had to deal with any of that. I should add that while the inside of my mouth was a mess, and my new Levi's were shredded by the rose bushes we were amongst, there were no visible marks on me while that biker had a mouse under his eye. So I went in looking better and came out looking better, but mostly I stopped them from abusing the neighborhood that I had grown up in.
