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yes,,you are correct i made the mistake of showing 12 week instead of 5..i could never find the 5 week ADCS-ADl.I think they based this(64 Points) AFTER 5 Weeks but not positive on that..8 months is how long the Piano Player and Artist are mentioned being upon A2-73 so that would be closer to the 36 Weeks Score..So I am looking for ever increasing scores..
I repeat these tests are not designed to test how much IMPROVEMENT..although they will capture it..
They are designed to Capture the RATE OF DECLINE..Because that is ALL ANY ALZHEIMERS DRUG HAS EVER DONE..
We are the Revolution..
There is big money against us..it is hateful..despicable..
one of the undebellies of disgust of Capitalism..but we have to help power through this..with BELIEF..
IMO- Anavex is in a QUIET PERIOD..that means ..they can not even TELL YOU that they are in a QUIET PERIOD..Why are they in a QUIET PERIOD?
You figure it out..
Placebo Effect- again is GONE after 5-6 Weeks in Thousands of patients in cblinded control arms..at 5 weeks..strong as Aricept..same patients at 12 weeks ZERO Effect-all the way back to baseline untreated population deterioration curve..
There is NO WAY Placebo at 12 Weeks had ANY EFFECT as 11 of 14 Patients at 12 WEEKS shows + 3.21 on ADCS-ADL.
NO WAY..PERIOD..NONE..NADDA..
THis is why Placebo Control blind is cruelty..we already have all the Blind, Placebo, Control Alzheimers patients that we need..
that is all we have had for the last 50 effing years!
Jimbo
You don't need rocket scientists or Doctors..
You may figure this out yourself..with Logic and a little bit of
time.
Go online and google one of the specific test that Anavex is using ..
ADCS-ADL
Daily living log by caregivers regarding patients..
Read the questions and ask yourself..How well would someone who
may play a piano, paint a picture, play golf, go shopping by themselves, Put on an Art Show of their own work..How well would they score upon this test?
My answer is pretty doggone close to perfect ..or 78 pts
our group started average at 64 and moved to 67 at 5 weeks without very
much medicint 24 days on, 12 days off9varying amount in MG)..
The test(s) are not designed to test IMPROVEMENT..they are designed to follow DECLINE..they are all trying to find a SLOWING of DECLINE
A2-73 are going to KILL THE TESTS..Just KILL THEM..I don't know want else the good Dr. has to say to everyone..or the Australian Govt ..A2-73 has curative properties..The INSIDERS REFUSE TO TRADE ON THIS KNOWLEDGE..
GOD BLESS THEM..One and ALL!
It is OBVIOUS to me that Anavex is in a quiet period..We could be talking about a $10 Billion deal or greater..no limit on License fees..
The market makers short this stock at their own demise..I again repeat..5 Market Makers will be out of business when THE deal is announced with Data, Funding and Phase 2/3 -with FDA Guidance..
Prana is still helping people..Huntington's and Alzheimers..
Waiting to revive AD Clinicals and Apporval for Huntingtons..
A2-73 just blows away anthing anyone else has ever had.
For Mac Farlane A2-73 is a LIFETIME Achievement ..
most posters on this board would not understand..
because we do not deal with watching the Tragic Thief
day in and day out..
Go Play the Effing Piano DOC! and God Bless YOU!
TRIFECTA
1. Full 12/ & Interim-26/38/52 Week data confirms Piano Playing, Picture Painting, Striping in 150 Yds down the middle and sinking the 5 Footer..
2. Phase 2/3 Announded with FDA Guidance, Multi-National, Multi-Site December 2016, with chance for quick review at 6 months for Compassionate Care Approval like Aricept.
3. BP Partner to fund, manage, direct and market with Upfront Cash Fee to Anavex and NO LIMIT LIcensing Fees for new First In Class soon to be SOC for Alzheimers.
You think calling out three horses pays a lot for a little..Wait until the Anavex Tri-Fecta comes in..the Horses are on the track..
is that legal? Well funny you should ask..Yes it is ..Market Makers are able to go long(hold a position, and go short a stock..there are rules..
A Favorite Illegal Game of Market Makers, not all, but some, is to find a Company either that they KNOW(through an offering circular0friends-cohorts)) that is bringing a Secondary Offering to Market..(DILUTION and LOWERING OF CURRENT shareholder VALUE- Guaranteed LOWER PRICE WITH ZERO RISK) and ILLEGALLY SHORT THAT STOCK..the Profits are RISK FREE, TREMENDOUS and ILLEGAL..However..they get fined less than they make..and it's now like they are shut down for doing it..
SO Guess what the Market Makers THOUGHT the good Dr. would do after the Reverse Split..A Major Secondary with Dilution..-NOT THE Lincoln Park-Low Dilutive Deal..SO (IMO) the MM Cabal Shorted, Shrkeili Shrieded, Fraudstein Whined and the Fools Belched and ROSEN LAW et al..-you see them at every road show..if you know what I mean..LOW and BEhold the Stock went from $14/sh to $3..WITHOUT a DILUTIVE Secondary..AND they BLAMED LONGS and ATTACKED LONGS..calling them "Pump and Dump" what a riot..oh well..
SO yes ..Market Makers may intermittently go short stocks..but not like (IMO) what I think they have done to Anavex..I personally think this is what SEC is investigating..WOn't be the first MM Short Cabal Charged..won't be the last..
IT IS THE MM Shorting the Stock! How do you defeat that? They short the tops and go long the bottoms..I think this is what SEC is investigating..GET ON WITH IT..
Not a Response to Fears Article, Not a Science article, Just a very simple, plain postive article. Well written. Good Read. from Seeking Alpha so it makes you wonder if next week he won't change his mind and start trashing Anavex for lack of Data..Hard world out there..even for those trying to sto Alzheimers..Hard World
River, if you were being sarcastic, I missed it..sorry. Xena ..love your posts..That would be the greatest Short Bear Trap EVER..announce the 12 Week..then wait for it..and spring the BP..would only have to wait like 2 days tops..you would capture another 3 millions shares short..that would be brilliant..
i am going to say this one more time so it may sink through..
Anavex MUST HAVE A BP Partnership IN PLACE before announceing
12 Week and Interim 26 Week. It would be a Financial Disaster to announce
never before seen Curative Test Results..Only to see the MM Short Cabal..
Run up the Share price..Sell Short the High..then engage The FOOL , the StreetSweeper, Bioinvest, etc, etc..the Law Firms..to
TEAR IT DOWN..
The BP will put a stop to it because tehy will destroy everyone who does it..so guess who deosnt do it to BP? yep..
so Anavex CAN NOT release the DATA until the BP Partnership is in place..they won't do it..and thousands upon thousands of small investors that would buy on such news, only to panic sell at the first Fartsteen Tweet, should thank them..
basparks..the 2 of the 32 had to come back into the trial. who knows when..but they completed 5 week..that was a n=32 then the inter.12 Week was n=30..so part of the delay could be WHEN the other 2 came back to finish Part B of 2a..They probably saw how well others were doing ..right?
Thanks George for update on A2-73 and Metabolite - 144- that makes sense why as a Sigma 1 Agonist..Anavex is kicking arse..it doesn't just hit it once..when it breaks down to 144 it rings the doorbell again..nice
look, i am speechless at the lack of intuitive ability displayed by investors. it is what is going to allow many of us believers to become exceedingly wealthy with Anavex. I appreciate Dado, George, Chemist more than any of you will ever know. People are getting better. it is simple stuff. that they are playing the piano and painting pictures is OFF THE WALL stuff. These are NOT THE SORT OF THINGS THAT YOU TEST FOR IN ALZHEIMERS DRUG TRIALS..let me say this SLOWLY..DO YOU KNOW WHY?
yeah..it really is that slow up there ..and God Bless..I know a lot of you don't understand the MM Short Cabal..or any delay in news..
but man..to not understand that a drug that is letting people play the piano again after years of deepening Alzheimers loss...
That you just don't accumulate as much as you are able..and cry about the stock being cheaping instead of thanking your lucky stars that you can buy more for less..
i do have a question for the people that were at the shareholder meeting..BASPARKS maybe..
Did anyone explain how we got back to 32? Or adding the Psychiatric Metrics to every Time DataCheck point?
We had 32 to begin with..and then they dropped out for reasons NOT ASSOCIATED with A2-73..
I would think it is the SAME PATIENTS back in, whose Caregivers saw other
patients/friends getting better.
That could significantly delay the cohort depending upon WHEN they got back in..especially if it was Later than the Last new enrolee..right?
They had data for 5 week for 32 right? I think so..than it was down to the DURTY THURTY..I liked THURTY..mor than 32..It rhymed with my Documantary I have Planned the Heroes of Anavex! The D.U.R.T.Y. Thurty!
What do I do with 32? really puts me in a tough spot..if you know what I mean..haha ..so Blessed to be a part of making people better..
I just take sugar pills now and call them A2-73! See if I can't get that Placebo Effect to last me 5 years..
ALL the MORE reason to squash THE PILL! It makes you smile and laugh, paint and play the piano! and worst of all there are rumors that some old people instead of Dying right and proper like make 9 AM TEE TIMES! When the hell do we get to play golf?
Newest Investment Idea..
Nursing Homes WITH Golf Courses..No more that 7,000 yards though..it's not like Anavex invented a new Golf Ball, just a new Good Life ACTIVATOR PILL!
Think of all the smiles, the laughs, the hugs..it makes me sick!
yes, laughing is very dangeorous..I think your post is addictive as hell, becuase I laughed and laughed..I think comedy is addictive as well..Terrible comedians! Arrest those addictive bastards!
and the funniest part is ..I really think riverterracekrew is serious..
Breathing , thinking . loving..all are very addictive..
IT IS CALLED LIFE!
Hi Dolphy, the need for more information is always there..
the News Stories out of Australia seem Fluff & PR but really they are so much more Data..When you review the ADCS-ADL test that is part of the Dataset you realize that these participants must be doing exceptionally well on almost ALL OF THEIR TESTS..it is very encouraging..I believe the 12 WEEK Data(Really only PK DATA) is being delayed Due to Multiple Third Party Reivews for CONFIRMATION prior to Phase 2/3 and a major BP Partnership. Basically we are in a quiet period. I would imagine the good Dr. would like the Quiet Period to be over before he appears in Public again..but at this point..it is not up to him..Look at it this way..ALL the other data must look pretty good..and longer it takes to confirm the PK..the MORE that must be at stake..Analogy..For a Death Benefit Policy of $10K to cover your funeral, a Life Insurance Co does not even require a Physical..Try getting a $ONE MILLION Life Insurance Policy without a physical..A2-73 is going through a COMPLETE PHYSICAL..
i think the day the deal is approved by both legal teams and boards of Anavex and BP Phase 2/3 Partner..I think it will be PFE, but the reality is ..whoever gives Anavex the best deal for future opportunity and growth that brings A2-73 to the most people, the quickest.. We are in the Billions..are we at double digit billions on 12 week, most of 26 week, some 38 week and some 52 week..Double Dig Billions might be a tough number for BP to justify with only 32 people..but..those number may be increased based upon milestones..and really not looking for a TOP LINE NUMBER as I DO NOT WANT A TOP LINE LIMIT..i am looking for Anavex to be a Licensing Agent..with territories, IND's, and new Drugs..while farming out for % of Sales..never selling...the good Dr. understands that he may have found "the pill". He brought A2-73 back from Oblivion.just a little over 2 years ago..So you ask WHEN..Honestly,let's just walk through it.
Anavex needs a BP Partner for Phase 2/3. FDA will want that settled before :hase 2/3 approved/begins. So. we know Dr. Mac mentioned the Protocol was written..Think Dr. Mac spoke out of turn..Maybe Phase 2/3 Protocol is just outlined..Either way ..doesn't that lead you to believe ..they already have the first version of Data for 12 Weeks? That they are just confirming 12 WEEKS Data through yet another Independent Source?
So..It is an OPEN TRIAL ..really the only Data that Anavex has not had access to is PK..Everything else is KNOWN TO ANAVEX(OPEN TRIAL). so maybe they don't have TRIPLE CONFIRMED 12 WEEK Data..but they have ALL the other data from ALL 32 PATIENTS and EVERY StAGE that those patients have completed..Right? SO BP has access to a LOT OF DATA,,including ..now the Depression/Anxiety Data..BP is able to see a LOT MORE than we are to consumate a deal. WE must assume, that what we see is what we get. Reversal in some,.. Amazing good health..(no deaths or episodes of ill health?-is A2-73 a GOOD HEALTH PILL TOO!) .. My point is I think we are really close to a deal..that when the PK data is confirmed by a Third Independent Party-Maybe even the BP itself- that Phase 2/3 will beging and the partnership will be announced. will it be the 5/17? or before..or after..i think it is sooner rather than later..maybe we could go backwards..IF they want trial to start at end of 2016,,December..
They have to coordinate/align Multi-Site/Multi-National participants for recruiting..so if you contact a Clinic NOW about running a 52 week trial with 200 enrollees..how much time do they need to prepare ..
I think you contact them in June and ask for commitment in July..so you may announce you locations and in August/September and then in December you may have your locations ready to go..with lots of participants..
So if you are going to Choose Locations in June, you need some pre-planning, coordination , command control. time to build the inter-company team, ..So I think ....everyone is just waiting on PK Confirmation..because..sometimes too good to be true..is simply called "the cure". look. no matter how many times you run a smile through a computer..you still get a smile.
i think they were just trying to keep the door open..
who knows if they will have data..Confirmed Data..double tested..triple reviewed..feel like they are going to supply Steel for the McKinley Bridge..
hi jimmy..
When they hit this thing with unbleivable 12 week and 26 week data...double verified..and then announce a BP Phase 2/3 for Billions..it is just going to be a very, very happy day..until then ..i do all i may to help my lesser believer friends..though they have eyes they do not see(paintings), though they ears they do not hear(the piano)..though they have a 280 yd drive and a good short game (they still can not score under 100)..
ladies and gentleman..
I rechecked the Hamilton Psychiatric Test and originally this was
only done at Baseline..what I imagine was an outrigger test to DQ anyone
with major Psychiatric Issues..
"Hamilton Psychiatric Rating Scale for Depression (HAM-D) Score [ Time Frame: Baseline at Period 1 ] [ Designated as safety issue: No ]"
It looks like they have Added this TEST to Every Data Collection Point..
Hence perhaps the Pre-Clinical CHECK for Depression/Anxiety.
I just can not put into words how deeply undervalued this opportunity is..
WHY DO YOU THINK THEY WENT BACK AND ADDED THIS TEST?
Da, dun, dun , dun.... da .. dun, dun. DUN da dun dun dun.dun!.
like a Free Capitalist Pig on Payday Baby..gettin me some more!
Can't get enough of that sweet , A2-73 Stuff!
Honestly at this point I don't think the good Dr. is negotiating around
Anavex Market Value..I think he is negotiating around
Biogen Market Value Increase of $29 Billion..because to a
Big Pharma Partner..that is what Anavex is worth..Minimum..
Co. that owned Neudextra..sold for $3.3 Billion(Not current news) ..
a Sigma 1 Agonist co.(Activated Sigma 1 Agonist using DM with Q)
thanks as usual to George..the Rock Star of Anavex Poster Boards!...
in one of the Posts regarding the good Dr. they say he mentioned the Scope of the Effect ot A2-73 may be tremendously broader HEALTH wise than JUST cognitive or mental. That the Sigma 1 Receptors are located ALL OVER the Body in Major Organs et al...WHERE HAVE WE HEARD THIS BEFORE?
Results are UNBELIEVABLE. IF you are selling ..you should never have been buying..I wll be adding one way or another..Someone asked if they thought A2-73 is addictive..Well if by Addictive you mean YOU CAN'T LIVE WITHOUT IT..Than yeah..A2-73 is going to be addictive..Addictive as an Infectuous Laugh!
Ditto the Thanks BASPARKS!
half the people there were the FB..impressive..
The DATA is NOT READY..so..what does that mean?
The DATA has existed in completed testing for awhile now..
It was thought at one point to be ready for release before the end
of the firs quarter..so why doesn't Anavex HAVE the Data, because it is
NOT READY. honestly..the ONLY REASON the DATA is NOT READY is because it is too good to be true and they are having it VERIFIED..
End of Story..Don't be mad about it ..the better the Data..
the longer the delay..
it's not snake oil..it is a beautiful, tremendous, curative for almost the worst plague to ever hit mankind..
If A2-73 was available right now. we could all take one to releive the stress and remember better times..like when the stock was over $6..oh that was fun! Just pretending to take A2-73 makes me happy! Have a great weekend!
Here is the ADCS-ADL Test:
https://www.nuedexta.com/do-i-have-pba
Someone that can Paint a beautiful Painting , than Organize their own Art Show..
please tell me how YOU think they score on this test?
Sigma 1 agonists are used to fight depression now, so it would make sense that A2-73 would fight for some space here..
When you start tying in AD and Depression..you really start to see the Corssover value of A2-73..
Pump you up!
So our ADCS-ADL baseline was 64 out of 78..
Over the course of 12 months this degrades by around 10
Points in AD patients.. So we might be looking at 58-59 at 6 months
As scale is proportionate( for my vocabulary lacking a better term)
At 12 weeks you would expect around a 61-62..
The interim 12 week has us over 67..
Here is my unbelievable point!
In order to paint a picture and manage an artist showing
The patient has to be at 75 or at the highest score of 78.
At 8 months the score would be expected 64-7.5=56-57
So at 6 months Anavex might be + 20points!
That my friends is TOO Good to be TRUE!
And that my friends is WHY(imo) we have not
Seen the data..
Don't worry be happy! Pretend like you are as healthy as someone who has been on A2-73
For 8 months! After reviewing the ADCS-ADL scale and questions. I want to share
Something with you.. If you are able to play the piano, create art work and schedule a showing,
And play golf or go shopping by yourself again
GUESS what you score on the ADVS-ADL test?
I am now more convinced than ever( like 10 minutes ago)
That the reason Anavex is not sharing the DATA is because it simply is too good, too
Unbelievably good to be true .. And Anavex is preparing as best they may for the insane response from
All quarters.. Literally looks like the patients could be scoring higher than ..
It looks like they could score 100%. After 8 months..
There is going to be tremendous GOOD pandemonium!
Review the questions yourself.. If you come to a different country nclusion please share it..
Hey if anyone would like to be a part of expanding use of Anavex's A2-73 ..either now or soon..please like facebook.com/anavexnow. going to try and start a WhiteHouse Petiion for Mercy Access..and other efforts..
disagree..
Anavex has a multi-dimensional First In Class Drug..it is NOT the same as ACAD as far as Property..Anavex's Scope is insanely broad and should NEVER SELL OUT..just Partner Up..the NAME Anavex needs to stand forever as the Name that began the DEFEAT of ALZHEIMERS!
Retail is not able to beat the MM Short Cabal..Retail trusts MM to run an orderly market not a corrupted one. So a Billion Co. sits at $200 Million until the Institutions OVerwhelm the MM Short Cabal. Is that a Data related issue? NO, it is NOT a DATA related Issue.
until AVXL retains a major Financial Firm OR engages a significant BP Partner, the SHORT Market Maker Cabal will win because they are IMMORAL and wiling to do ANYTHING to crush momentum. Data will not change the Market Makers IMMORAL ACTIONS, nor will it change Fear and Greed. A BP Partner is coming..soon
So the MM Short Cabal is really gotten themselves in a Pinch Haven't they? Used to be so easy to steal from current shareholders. Offer an easily persuaded CEO a couple hundred Mil to sell shareholders down the river, then cash in your SHORT SALES at the lower after Secondary Price..Cha Ching..Illegal as hell..but hey YOU ARE A MM! You deserve to be able to STEAL OTHER PEOPLES MONEY! ITS JUST RETAIL CLOWNS! but whoa is YOU! the good Dr will have NO PART in your SICK GAME. the good Dr. is the LARGEST SINGLE SHAREHOLDER of Anavex and HE WON'T SELL ANYONE HIS STOCK CHEAP..EVER. HE IS BUYING MORE for all we know. And soon come the announcements..Partnership, Unbelievable Data for 12 Week and ARE YOU KIDDING ME..Interim 26 WEEK is now off the CHART(IMO)..NEW IND, NEW MULITI-SITE International Alzheimers PHASE 3..The MOtley FOOL has done their best..other lying Investor Cabal's have tried..We've attacked Anavex supporters so they've quit being public..and yet through it all..
WE ARE STILL SHORT MILLIONS AND MILLIONS OF SHARES! What are the MM going to do? If they start trying to cover..EVERYONE WILL BUY TOO and NO ONE will SELL!..If they WAIT..well you KNOW what is coming..SO THEY HAVE to TRY AND GET YOU TO SELL Before the NEWS HITS THEM SO HARD..a FEW of THEM WILL BE OUT OF BUSINESS!..I SAY FIVE..I just picked that number out of my arse.
But here is the thing about Greedy MM's that steal from Shareholders and break the law. They can not be trusted by ..guess who..the OTHER MM's. So guess what..guess who is covering right now..THE INTELLIGENT MM's! As they tell their co-horts oh yeah..this things going down..they are quietly buying..maybe even using a third party to do their bidding..but they are covering their Arses..Who are going to be the MM's that don't follow suit? We will be reading about them in the WSJ as they can no longer MEET THEIR NET CAPITAL REQUIREMENTS..That will be a great contrast story alongside a painter who may paint, and a music maker bringing tears to her husband!
Another Short Hit Piece compliments of the MM Short Cabal. man are they desparate..SO WHAT if they are already taking names for a Phase III multi-site Australian Phase III which will act as part of a probable multi-international multi-site Phase III..Soon..LOOK at that BOOK value! That piano song was no Mozart! That Painting is no Van Gogh(man where is spell check!) that golfer didn't even break 100..and he was horrible out of the sand..and he kept writing down the wrong score! What is the book value of another round of golf, or another painting or another piano song..or knowing that your daughter only takes one lump of sugar in her tea? What is the effing book value of that heartless & soulless shortsellers? someday uou will stand before our Creator and answer what YOUR BOOK Value is..better hope it's more than $.36
dun trading around the core..ready to say goodbye to affordable anavex..cost of trying to trade below $10 a share about to become very expensive..
Powerwalker..Licensing AVXL to different partners in different parts of the world makes TOTAL Sense..Get cash to pay for Phase 3 and you have motivated partners..but you never lose control..I like it..
I read my last post and it sounds like I am pumping the opportunity that Anavex has right before their Annual Shareholder Meeting. Sorry good Dr. perhaps my expectations are too high for you..but in reality..I think you are already 25 steps ahead of me..and THAT is WHY I am so glad you are the CEO of Anavex and OUR largest SINGLE SHAREHOLDER!
Protocol is DONE. Multi-Site/International Locations including Australia. Currently Recruiting for Phase 3 in Australia.
the ONLY way this is happening is with a BP partner..AVXL is not set up to begin International Multi-Site Phase 3 Trials without a Major BP Partner.
Deal is DONE..No Secondary Necessary! BP Going to PAY FOR TRIAL and PAY ANAVEX Marketing Fee..The question is WHO and HOW MUCH..
My Guess Pfizer and ..5 Billion..with milestones and ZERO LIMIT as to HOW MUCH PFE will pay Anavex over time....
nicely done Blu_1
look..No DRUG has EVER worked before..Aricept is a JOKE.
They can design this Phase 3 for 1 year,,which would be about a 2 year duration with recruiting ..but No ONE is going to wait that long if
people keep showing these kinds of CURATIVE EFFECT..and for goodness Sakes "WHY SHOULD THEY?" then you could have 6 months a compasshionate care protocol where they unwrap the blinded study see how well A2-73 and immediately give it approval....The Authority will have a hard time even waiting this long..IMO