A2-73 was never expected to cure anything. It is a CNS homeostasis drug, which is expected to lead to CNS improvements, but not necessarily CURES. For example Rett is a genetic problem, which cannot be cured by A2-73, but it appears to improve the patients lives. AD patients on A2-73, showed cognitive improvements in certain subsets of patients, which has been thoroughly documented
You make an important point which I have also considered. One assumption might be that CNS recovery results in cognition improvements and other fundamental life skills. Not a CURE but certainly effective to ensure an improvement in the patient's quality of life. I call that a win, which we expect to continue to build as the patient continues to be treated w/A2-73 or follow on treatment. If that is the worst thing that happens then we can declare a victory. This has never been done.
My strongest opinion is the recovery rate and it's degree will vary w/each individual according to their starting physical health and their own makeup. I am linking an interesting paper on complex systems cellular composition which may shed some light on what we might expect going forward.
“Cells don’t necessarily care about their history,” Klein says. “They may have to transition to one identity in one place and another identity in another.”
I do expect we will see positive results. IMO, Dr.M. chose to go w/PDD b/c he has strong evidence that the path we are on is correct and that he can validate the CNS cellular Homeostasis thesis impact.