Anavex Life Sciences Corp (AVXL)

[nidan7500]

A2-73 was never expected to cure anything. It is a CNS homeostasis drug, which is expected to lead to CNS improvements, but not necessarily CURES. For example Rett is a genetic problem, which cannot be cured by A2-73, but it appears to improve the patients lives. AD patients on A2-73, showed cognitive improvements in certain subsets of patients, which has been thoroughly documented

You make an important point which I have also considered. One assumption might be that CNS recovery results in cognition improvements and other fundamental life skills. Not a CURE but certainly effective to ensure an improvement in the patient's quality of life. I call that a win, which we expect to continue to build as the patient continues to be treated w/A2-73 or follow on treatment. If that is the worst thing that happens then we can declare a victory. This has never been done.

My strongest opinion is the recovery rate and it's degree will vary w/each individual according to their starting physical health and their own makeup. I am linking an interesting paper on complex systems cellular composition which may shed some light on what we might expect going forward.

https://www.knowablemagazine.org/article/living-world/2020/single-cell-studies?utm_source=twitter&utm_medium=post&utm_campaign=originals&fbclid=IwAR0XhoBZ7XaX5FkuyoTSixFfbRcalytpl0RTtpoz7Z7qdydU09Ozjg0vQ0g

“Cells don’t necessarily care about their history,” Klein says. “They may have to transition to one identity in one place and another identity in another.”

I do expect we will see positive results. IMO, Dr.M. chose to go w/PDD b/c he has strong evidence that the path we are on is correct and that he can validate the CNS cellular Homeostasis thesis impact.