Replies to post #236820 on Anavex Life Sciences Corp (AVXL)

[nidan7500]

A 99.6 percent failure rate means there are only four approved drugs to treat Alzheimer's on the market,

So, simply stated, we are either a one or a zero. Got it. BTW, some of us have already considered that.

[tootalljones]

Never agreed with this analogy. These old statistics, even if actually true, which is also a complete lie, are static and captive of other eras.

It is like saying in betting football games, as a for instance, that the last 131X the Chicago bears have played the packers, going back to 1960 (2games per year and includes 11 post season contests, the AWAY DOG who was getting 9 or more points has covered the spread 60% of the time. This week the Bears are playing in green bay and they are getting 10 points, therefore there is a 60% chance they will cover. The Bet is therefore Chicago Bears. Is this really the way to invest your hard earned money? Some would say yes. Despite different standards, testing, methods, technology, accumulated knowledge, funding, personnel, etc.

The people and coaching staffs and a dozen other factors of the prior 60 Bear and Packer teams, going back to 1960, are not the teams playing this weekend. They have no connection which is investable in the here and now.

And the percentage in common parlance is also media fodder. Can you identify the 1000 prior phase 2 Alz drugs which comprise the field where 4 have been approved? ...o you say they werent even phase 2 drugs, that this means any drug ever identified with mouse testing, o you say it actually wasnt mouse testing,????........things get very nebulous and mythical. They say Paul Bunyon chopped down 197 trees in just 6 months time.....that is a fact.....blah blah blah.

does anybody really believe these stats are valid? that testing today and methods today are the same as 1960 or 1970 or 1980, etc..
This is all nonsense.

Instead, stay with the trial data the trial data the trial data the trial data....and the anecdotal data as well......stay with current events please. ...

[nidan7500]

Why All the Alzheimer's Drugs Fail?

Some of us have concluded that such a comprehensive trial failure rate is attributable to the flawed process of investigation being used, AKA stabbing around in the dark for a symptomatic solution. While still no proof of root cause can be seen. ( in fact one must ignore causal contradictions)

Alternatively, we consider the AVXL MOA of restore and enable CNS Cellular homeostasis as a natural and far more effective process. So far, the results are encouraging. We continue to understand more about how this process works and will eventually understand WHY it works. This is impressive when we consider the decades of repeated failures where all we learned was repeating the same thing yields just about the same failure.

We note there are still some who will attempt to squeeze more money from the trials process at the expense of the general patient and investor population. Somehow, they get away with it. That is the real mystery for some of us.

[Investor2014]

The single dominant Alzheimer's theory that scientists and BP have been repeating over and over each time expecting a different outcome is the definition of insanity. Therefore, no wonder the failure stats are so high and still continues to be re-enforced once again last week.

The Anavex approach is very different. That in itself does not guarantee success, but so far it looks promising and is not part of the same set of stats.

[jimmy667]

The question regarding OTC is light years off base and speeding like a runaway train in the wrong direction on the wrong track. Anavex is not an OTC penny stock it is a fully reporting Nasdq Company in full compliance with all Nasdq regulations and has been each and every day since uplifting to NASDQ IN Oct 2015. It has never had even one deficient issuer notice.
The question is rather than lumping AVXL in with the Universe of OTC stocks what percentage of Companies that successfully uplifted to NASDQ went on to be successful? One might see that this lie of statistics that all OTC stocks fail is that all of the successful Companies the started in the OTC matured into fully reporting Companies and uplifted to fully reporting exchange like NASDQ NYSE AMEX and the ones that didn't failed. Not because they started on the OTC but exactly because they failed before reaching fully reporting status.
Anavex had poor management before Missling arrived in 2013-2014 and he quickly moved the Company forward to the point of uplifting to NASDQ in the October surprise of 2015. Now Avavex is advancing simultaneously on three fronts winning every battle fought the Company has fought. Gaining the objective on two of the three fronts will ensure complete victory gaining the objective on even just one front will allow Anavex the put more resources into the other two fronts and open up new fronts and gain powerful Allies on all fronts.
Anavex is battling the root causes or cascades of reactions of CNS malfunctions not symptomatic relief. Therefore it takes longer than the quick strikes that attack the more troublesome symptoms. The penultimate objective is to shift the paradigm of treating symptoms to solving the underlying malfunctions on a cellular and organelles level. To this endeavour Anavex is employing the greatest ally medical science will ever have, the Human Body Itself more specifically by concommitally modulating the SR1 and M1 receptors at the cellular organelles level.
If this effort is successful Anavex could possibly occupy nearly the entire CNS field as Gilead once did with anti-viral drugs.
When I first invested in GILD everyone said no cure for HIV or other Viral all attempts have failed. Sarcastically "Cure for HIV yea right haha they will fail" and the share price of GILD lanuashed for years. Sound familiar?