Replies to post #231342 on Anavex Life Sciences Corp (AVXL)

[frrol]

Yes the paper is about allosteric agonists and mentions 2-73 but doesn't actually call it an allosteric agonist, just an agonist.

[georgejjl]

Allosteric modulators can be positive or negative effectors (PAMs or NAMs, respectively). PAMs increase the activity of the ligand, while NAMs block it (Figure 1).

https://www.frontiersin.org/articles/10.3389/fphar.2019.00223/full#F1

Functional responses of allosteric modulators. Positive and negative allosteric modulators (positive allosteric modulators and negative allosteric modulators) may modulate the affinity and/or the efficacy of orthosteric agonists.

Good luck and GOD bless,

[georgejjl]

Serendipitously, the (4R,5S)-isomer (E1R) was discovered to interact at the sigma-1 receptor by increasing the binding affinity of an orthosteric ligand, which is characteristic of a PAM.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689070/pdf/nihms918934.pdf

Good luck and GOD bless,