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Monday, January 20, 2020 11:01:21 PM
Allosteric modulators can be positive or negative effectors (PAMs or NAMs, respectively). PAMs increase the activity of the ligand, while NAMs block it (Figure 1).
https://www.frontiersin.org/articles/10.3389/fphar.2019.00223/full#F1
Functional responses of allosteric modulators. Positive and negative allosteric modulators (positive allosteric modulators and negative allosteric modulators) may modulate the affinity and/or the efficacy of orthosteric agonists.
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