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georgejjl

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georgejjl

Re: Doc328 post# 231342

Monday, 01/20/2020 11:11:42 PM

Monday, January 20, 2020 11:11:42 PM

Post# of 468244

Serendipitously, the (4R,5S)-isomer (E1R) was discovered to interact at the sigma-1 receptor by increasing the binding affinity of an orthosteric ligand, which is characteristic of a PAM.



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689070/pdf/nihms918934.pdf

Good luck and GOD bless,
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