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Mellowmood77

09/17/19 12:29 PM

#214786 RE: Whalatane #214783

Clinical ASCVD would indeed be under secondary prevention and an event is not required:

Documented coronary artery disease (CAD; one or more of the following primary criteria must be satisfied):
• Documented multi vessel CAD (≥50% stenosis in at least two major epicardial
coronary arteries – with or without antecedent revascularization);

• Documented prior MI;

• Hospitalization for high-risk non-ST-segment elevation acute coronary syndrome
(NSTE-ACS) (with objective evidence of ischemia: ST-segment deviation or
biomarker positivity).


2. Documented cerebrovascular or carotid disease (one of the following primary criteria must be satisfied):

• Documented prior ischemic stroke;

• Symptomatic carotid artery disease with ≥50% carotid arterial stenosis;

• Asymptomatic carotid artery disease with ≥70% carotid arterial stenosis per
angiography or duplex ultrasound;

• History of carotid revascularization (catheter-based or surgical).


3. Documented peripheral arterial disease (PAD; one or more of the following primary criteria must be satisfied):

• Ankle-brachial index (ABI) <0.9 with symptoms of intermittent claudication;

• History of aorto-iliac or peripheral arterial intervention (catheter-based or
surgical).


Primary prevention requires you to have diabetes type 1 or type 2 plus one additional risk factor in the reduce-it trial.

If you have diabetes and your additional risk factor is, say, ankle-brachial index (ABI) <0.9 with symptoms of intermittent claudication, or anything from the previous table, you will be counted as secondary not primary.

bfost

09/17/19 3:07 PM

#214815 RE: Whalatane #214783

Whal - See my previous posts for details on the topic.

IMO it's clear that you can have ASCVD without an event based on diagnostic tests.

Clearly Reduce-It did not require a MACE to be included in the secondary prevention group

Common sense will also tell you that it's silly to think the minute before you have your first MI you don't have ASCVD and the minute after the MI you do!

Good luck!