It seems that Adam17 with direct links to exposure of flipped PS...and iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling
In the provisional clinical opinion, ASCO recommends that if a doctor is thinking about giving an EGFR TKI to a patient with advanced non-small cell lung cancer who has not previously had chemotherapy or an EGFR TKI, the doctor should test the tumor EGFR mutations to determine the most appropriate treatment. Testing for EGFR is done on the sample of tumor removed during a biopsy.