NorthWest Biotherapeutics Inc (NWBO)

[GermanCol]

Ex, let me make this clear for you, so you can see there are no serious math issues here, maybe some serious understanding issues in the post I'm replying to.

There are two types of censored patients:

- Left censored: Patients that were lost to follow at the time of the analysis.

- Right censored: Patients that were in the trial and alive at the time of the analysis (we don't know how long they are going to live).

Also, you need to remember that not all the patients entered the study at the same time, so at the time of the interim analysis, there were patients all the way between 19 and 120 months (10 years) from surgery, as can be seen in the following timeline I prepared:



With this in mind, we can state the following:

- For the range between 0 and 19 months from surgery, all the censored patients are left censored (lost to follow). This is true because at the time of the interim analysis all patients had 19 months or more from surgery. So, if we look at the definition above, there is no way a right censored patient would appear in that range.

- For the range between 19 and 36 months from surgery all the censored patients were right censored, meaning they were alive. This is because, even though there can be found right and left censored patients in that range of time, the number of 64 patients alive calculated in my pervious post (link below) is exactly the same number of 64 censors counted on the chart below. Each censor is a small vertical line located at the time the patient that was still alive had from surgery when the interim analysis was done. This also makes sense because is much more probable to find left censored patients (lost to follow) towards the beginning of the trial (first enrolled patients).

https://investorshub.advfn.com/boards/read_msg.aspx?message_id=168777187




Also from all this analysis, all the patients that were alive and in the trial at the time of the interim analysis and were past 36 months from surgery (first patients enrolled) are not part of the censored patients

Based on the exact same math, your sentence:

the number alive at 36 months was 64( 64--0). And the number alive at 19 months was 0 (64-64).

Needs be replaced by the following:

From the last 149 patients enrolled the number alive at 36 months was 64( 64-0). And the number alive at 19 months was 0 (64-64) , as it was 0 the number of patients already enrolled because they were not yet in the trial.

The number alive is 0 because there were 0 patients in the study they were still starting to go to surgery and enrollment.

So there are no math issues in my post unless you can refute my analysis with real arguments.