Cancer and Mitochondrial Dysfunction.
The Warburg Effect, a putative cause of cancer, is attributed to mitochondria that no longer undergo proper glycolysis, step-by-step breakdown of glucose yielding energy-providing adenosine triphosphate molecules (ATP). Instead, the mitochondria undergo fermentation, failing to use oxygen to efficiently produce ATP. This mitochondrial malfunction causes the cancerous state.
We know that Anavex 2-73 reconnects rough endoplasmic reticula to mitochondria, allowing efficient transfer of ATP to the rough ER, which uses the energy of ATP to properly fold cellular proteins into functioning enzymes, some of which degrade and remove the waste proteins (beta-amyloids, tau tangles) that cause Alzheimer's symptoms.
But I don't see Anavex 2-73 as being able to restore normal mitochondrial respiration (glycolysis). It works on the exterior of mitochondria, and probably doesn't affect internal mitochondrial chemical reactions.
BUT, perhaps the reason cancerous mitochondria fail to work properly is because fully functioning, reaction-controlling enzymes are not present, because of a rough ER/mitochondrial disconnect --- which Anavex 2-73 could restore, thereby making proper mitochondrial enzymes to support normal respiration, glycolysis. According to the Warburg hypothesis, the cell would no longer be cancerous.
Of course, this is something that oncologists will easily study in cancerous rats or mice. Perhaps some Anavex molecule will allow this sort of cancer treatment.
