Replies to post #106608 on Anavex Life Sciences Corp (AVXL)

[dadofmarcmax]

If it were so easy......

While I do enjoy your posts, falconer, sometimes you take too dramatic leaps by implying that causation of symptoms are directly related to the intracellular processes you write about. For example, you AGAIN seem to imply that the aggregation of insoluble misfolded protein aggregates directly cause the cognitive decline symptoms of dementia. How can you be so sure? That's quite a leap. Perhaps there is a role but there are likely multifactorial reasons why these cognitive symptoms occur, not just one. Could the decline actually be related to numerous microseizures in the hippocampi of demented patients......perhaps? Perhaps the degeneration of the enterorhinal cortices of demented patients is greater in scope than nondemented peers.

Perhaps the mechanism of action of 2-73 involves multifactorial effects on multiple intracellular processes including the restoration of the mitochondrial-ER disconnect that you speak of.

NOTHING in science is so simple and there certainly is much risk involved.

Just be careful on what you ascribe causation towards, that's all......