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They appear to be an excellent firm if the senior advisor is any indication.
FWIW Anavex website back up. Don't recall if this news item was there before - Missling will be one of 5 speakers at June 7 Bio Conference.
https://mybio.org/event/member/259165
re:" avxl website"
Maybe they are under dos attack by hackers. We seem to have suffered every other kind of attack so far...
Dementia is a growing problem in the world. Many of us have personal stories as I do with my family member, but I don't wish to dwell on that except to say, there was a long period of denial before seeking a medical diagnosis.
There's already been a president with Alzheimer's in office. Fortuneatly, Reagan was able to finish his last term ok despite increasing forgetfulness. It only came out later that he had AD. It was a best case scenerio, and the nation came out of it safely. It's possible it may touch all our lives on a national level again.
One of the leading candidates appears to be exhibiting early signs of dementia.
http://www.deathandtaxesmag.com/265291/donald-trump-dementia/
"Trump’s father, Fred Trump, suffered from Alzheimer’s Disease before his death in 1999. Recent studies have shown that Alzheimer’s affects its victims much earlier than previously thought"
"... Trump ... is 69 years old. He’ll be 70 on Election Day 2016"
"It would be extraordinarily easy for Trump to disprove that he’s suffering from dementia. All he has to do is take a MMSE/Folstein Test and release the long form results"
Please put politics and issues aside but it would be interesting to hear what some of the dementia experts think, from a medical point of view. Also, many of us have learned a lot about AD from studying Anavex research and experiance with our own afflicted family members.
re: "...requires short term memory to execute. "
That's what I meant. I agree.
Basically what we are seeing is a good sign that Anavex 2-73 is working.
Reading sheet music and playing from notes is not creativity. It is a learned memory skill like typing or reciting at a spelling bee.
I watched an interview with a concert violinist. The interviewer started to praise him for his creativity but the violinist corrected him to say that what he did was not creativity. He then cited a jazz combo who performs free style jam sessions as an example of musical creativity.
"miracle cure"
re: endoplasmic reticulum
And it's such a cool sounding term. When I pronounces it I can almost fell my IQ going up a couple of points. I keep waiting for the opportunity to use it in everyday conversation, but, alas. :)
re: "I found the ultrasound article interesting too, also AU research. Seems a shame they can't take a non-invasive therapy like that straight to human trials. "
No way I would volunteer for that. For one thing, I personally find the nerve jangling discomfort of ultrsonic teeth cleaning nearly unbearable, really bad when they blasted a cavity, and have become slightly obsessive about anti-tartar oral hygeine, taking great lengths to avoid the procedure. I also submitted to it as a pain treatment once- made it worse. So, instinctively, I say, keep it away from my poor brain, it faces enough challenges as it is. :)
The ostensible treatment doesn't fix anything inside the cell so would need to be repeated periodically over the life of the patient. The vibrational g-forces required to produce cavitation are quite high and we know that boxers and football players develop brain problems with repeated jarring hits to the head.
And what happened to the 25% of mice that failed? Not enough power = no effect, too much power = cell damage? Also. rapid localized heat buildup can, in effect, "fry" the cell. I suspect that there is a fairly thin line between presumed therapudic effect and cell disruption. That is, after all, a major application today:
http://www1.lsbu.ac.uk/water/enztech/ultrasonic.html
"The treatment of microbial cells in suspension with inaudible ultrasound (greater than about 18 kHz) results in their inactivation and disruption. Ultrasonication utilises the rapid sinusoidal movement of a probe within the liquid. It is characterised by high frequency (18 kHz - 1 MHz), small displacements (less than about 50 mm), moderate velocities (a few m s-1), steep transverse velocity gradients (up to 4,000 s-1) and very high acceleration (up to about 80,000 g). Ultrasonication produces cavitation phenomena when acoustic power inputs are sufficiently high to allow the multiple production of microbubbles at nucleation sites in the fluid. The bubbles grow during the rarefying phase of the sound wave, then are collapsed during the compression phase. On collapse, a violent shock wave passes through the medium. The whole process of gas bubble nucleation, growth and collapse due to the action of intense sound waves is called cavitation. The collapse of the bubbles converts sonic energy into mechanical energy in the form of shock waves equivalent to several thousand atmospheres (300 MPa) pressure. This energy imparts motions to parts of cells which disintegrate when their kinetic energy content exceeds the wall strength. An additional factor which increases cell breakage is the microstreaming (very high velocity gradients causing shear stress) which occur near radially vibrating bubbles of gas caused by the ultrasound.
Much of the energy absorbed by cell suspensions is converted to heat so effective cooling is essential. The amount of protein released by sonication has been shown to follow Equation 2.9. The constant (k) is independent of cell concentrations up to high levels and approximately proportional to the input acoustic power above the threshold power necessary for cavitation. Disintegration is independent of the sonication frequency except insofar as the cavitation threshold frequency depends on the frequency.
Equipment for the large-scale continuous use of ultrasonics has been available for many years and is widely used by the chemical industry but has not yet found extensive use in enzyme production. Reasons for this may be the conformational lability of some (perhaps most) enzymes to sonication and the damage that they may realise though oxidation by the free radicals, singlet oxygen and hydrogen peroxide that may be concomitantly produced. Use of radical scavengers (e.g. N2O) have been shown to reduce this inactivation. As with most cell breakage methods, very fine cell debris particles may be produced which can hinder further processing. Sonication remains, however, a popular, useful and simple small-scale method for cell disruption."
Simply blowing away all the amyloids (instead of fixing the cell, like Anavex2-73 does) besides not being "the solution" also exposes the cells to infection. Interesting full article. I have posted an excerpt:
"A new study finds that a key protein implicated in Alzheimer’s may normally protect the brain from infection"
http://www.scientificamerican.com/article/antimicrobial-mechanism-gone-rogue-may-play-role-in-alzheimer-s-disease/
[...]
"The idea that amyloid beta has a positive function in the body could potentially change how scientists approach potential treatments. Instead of attempting to completely eliminate the protein, “we might want to think about just dialing it down,” Tanzi says. Moreover, Moir adds, the drugs in trials now are for the most part designed to reduce inflammation by targeting pathways in the adaptive immune system. But if amyloid production and deposition are innate immune responses, then targeting pathways of innate immunity or the microbes themselves may be the way to go.
They do not expect convincing the scientific community of this to be easy. “This is really going to cause a lot of unrest in the field,” Tanzi says. “Any new revolutionary discovery is first ridiculed, then violently opposed, and finally taken to be self-evident. We’re ready for the ridicule and the violent opposition, and we think we have enough data so that we can look forward to self-evident.” "
re:"cure"
In actual usage as recorded in various dictionaries, there seems to be quite a bit of lee-way.
e.g. Bing def search:
cure1. [kyo?or]
VERB
1. relieve (a person or animal) of the symptoms of a disease or condition:
"he was cured of the disease" ·
synonyms: heal · restore to health · make well/better · cleanse
NOUN
1.a substance or treatment that cures a disease or condition:
"the search for a cure for the common cold"
synonyms: remedy · medicine · medication · medicament · antidote ·
Then there's:
Collins dictionary
miracle cure ('m?r?k?l kj??)
?Definitions
noun
1. (medicine) a successful treatment for a disease that was thought impossible to cure ? a miracle cure for some horrible disease
However, I think that I am going to try to go with the term "effective treatment", having firsthand knowledge of what "ineffective treatment" is.
Looks like I should have stayed with my initial hunch that it was not about BK. At 0.70 premarket now.
Sorry can't reply to private email. In the news they report that a volcano is erupting in Costa Rico - raining down ash. I am just an occasional observer in this stock at present, however, I thought that I would mention it in case no one knew about it and in case it could have an effect on coffee in the area. If it kills the plants, they won't need much spray, having a bigger problem. Maybe the ash will kill the fungus? Maybe no effect? Might be something to check further. Like I said, I just thought that I would mention it in passing in case it could have some bearing on ONOV activity in the area because some people here are still invested.
wonder if the volcano will affect coffee...
With so many dubious drugs approved, there is no question Anavex 2-73 will be approved on its own merits. It already has a good safety profile established and every indication is that it is better than Donepezil but all it needs to be, is to be at least as good.
For those impatient with Anavex taking the straight and narrow, get a load of these guys:
(maybe they should adopt a skull and crossbones as a logo - seems appropriate)
http://www.msn.com/en-us/news/us/bone-cement-company-accused-of-experimenting-on-humans/ar-BBtjQc6?li=BBnb7Kz
Bone cement company accused of experimenting on humans:
"... bought the California-based Norian Corporation, which had developed bone cements used in skull and arm-bone surgeries. Synthes planned to alter Norian's product so it could be used in spinal surgeries, but that meant a long FDA-approval process.
Synthes opted to take another route, according to court records.
Wyss directed a few sites to perform 60 to 80 procedures in spinal surgeries using the Norian bone cement and to publish clinical results. He recruited Chapman and other surgeons to test-market the product on patients, court records show.
Chapman and a colleague at UW conducted an experiment in 2002 using bone cement on pigs. The material caused clotting, killing the animals. The doctors also tested it on human blood in test tubes. Again, it caused clotting. Chapman reported his findings to Synthes.
The company pushed forward with its plan to "test market" the product in spinal surgeries, court records show.
In 2003, a patient died on a Texas operating table after a spinal surgeon injected Synthes bone cement into her vertebrae. Another patient died seven months later in California, and another died four months after that."...
CEO of Synthes an interesting character.
https://www.activistfacts.com/person/hansjorg-wyss/
Actually he might not seem all bad, depending on one's personal political views, but, still, kind of bad when routinely wielding influence with such impunity adversely affected patients outcomes. I wonder if those trying to throw roadblocks in Anavex's path realize that they may be adversely affecting AD patients' futures.
http://www.washingtonexaminer.com/podesta-palmieri-wyss-links-could-be-a-problem-for-hillary-clinton-in-2016/article/2560434
Some big sharks swimming around out there. I keep wondering what is really behind the nasty attacks that Anavex has had to endure. Guess exposure of malfeasnce by big players sometimes only comes out years later.
A lot of what happens in the stock market and politics, if it doesn't seem to make sense, consider that it could be the result of people with a lot of (probably ill-gained) money to throw around who are in the habit of, well, basically cheating, to get what they want.
AVXL share price this low, at this stage of development, doesn't make sense except as a smokescreen.
re: "... trimyristin, the triglyceride of myristic acid. Besides nutmeg, myristic acid is also found in ... rhizomes of the Iris, including Orris root."
"Orris is also an ingredient in many brands of gin."
https://en.wikipedia.org/wiki/Orris_root
Not that I am particularly fond of the stuff, but always wondered what gave gin it's unique taste. Amazing where a little research can lead.
I think in March I said 6 monthes.
So, OK, 4 months from here. Counting down... See how time flies. :)
Share price volatility is to be expected but looks to be firming to me. People are starting to get interested and I think that those of us who saw value here, despite the derisions, early on, will be vindicated as we approach approval and revenue status.
re: "The anti-cholinesterase activity was evaluated of the ethyl acetate fraction of the methanol extract of Myristica fragrans Houtt (Myristicaceae)..."
"Myristica fragrans is an evergreen tree indigenous to the Moluccas (or Spice Islands) of Indonesia. It is important as the main source of the spices nutmeg and mace. "
Hidden benefit, eh? I like putting nutmeg in beef stroganoff, rice pudding, and apple pie.
Inclined to think maple syrup is somehow more related to how Anavex 2-73 works, albeit a more partial and weaker benefit, whereas nutmeg, not so much, since it seems to relate more to simply maintaining acetylcholine. Could explain people perhaps getting a little unconscious boost from egg-nog during winter holiday season. :)
re: "Since refine grains and sugars
Yes, too much starch (and sugars). Very high prevalence of corn syrup in everything (even canned spaghetti sauce - real authentic Italian there). Not to mention going into our cars (corn ethanol) It's probably not too surprising that cereal figures big in "official" approved diet i.e. so called " food pyramid" . There was a tv special a few years ago about big agri $100M spending on political contributions on top of lobbying. The idea is that if you need to spend millions to get billions, it makes for good business sense on Wall St.
Some of the suspected market manipulation affecting Anavex stock, would require tying up a lot of dough, not caring about covering NSS to sink the sp, for instance. I guess that certain big money interests and high rollers don't always have the best interests of consumers and retail investors at heart. Best to take what pundits espouse and "official" positions with a grain of salt. To weigh what is being presented to the masses against one's own DD and experience.
re: "Capsules were administered under fasting conditions with 200 mL of still mineral water. "
Taking most anything e.g. aspirin on an empty stomach is bound to have some gastro-intestinal effects.
Also having experience with going on diets over the years, head-ache and dizziness can also be expected as a result of going without eating like that until one adjusts to reduced food intake / change of diet.
Up from here. :)
OK, that scared me. I'm out.
I bailed on Blackridge for this. Out of the frying pan into the fire. Now out of the frying pan and back on the hunt for a recovering oil play. again... :)
re: "Toyoma Chemical is also using similar MOA as Anavex..."
Toyama Chemical's AD drug {from their website)
T-817MA
"Currently available drugs for AD in the world are mainly choline esterase inhibitors, which provide symptomatic relief through activating acetylcholinergic neuron in the brain. According to this mechanism, however, such drugs are regarded to be ineffective at addressing the underlying causes of the disease, and do not prevent the progression of the disease in the long term."
I agree. And Anavex knows this as well. That is the "10 cups of coffee" scenerio.
"T-817MA has neuroprotective properties. Toyama Chemical has demonstrated that T-817MA prevents neurodegeneration induced by Amyloid-ß protein. Accumulation of Amyloid-ß protein is considered to be central to the pathogenesis of AD. The neuroprotective properties of T-817MA were also observed in a mutant tau induced AD model. Besides these neuroprotective properties, T-817MA also promotes neurite outgrowth. On the basis of the currently available nonclinical data, Toyama Chemical considers T-817MA to be one of the most promissing neuroprotective agents in preventing the progression of AD."
That is not how Anavex 2-73 works. Blowing away nasty amloid proteins has been proven to be a dead end when taken as an end in itself. The reason the cells are puking out protein tangles is because they are sick. The reason these nueral cells stop working properly to retrieve memory is because they are sick and although cleaning away the mess helps the signals get through, when the cells starts losing their ability to signal, it doesn't do any good because the cells are still sick.
This other thing they report that T-817MA does is very different from Anavex 2-73 if not a little alarming. The promotion of nuerite outgrowth makes it appear to act like a kind of growth hormone. Considering the abysmal results obtained in clinical trials with trying to inject stem cells into spinal injury victims, its value in treating AD seems dubious. Stroke victims, maybe, if the new sprouts could somehow find their way to connect to the right destinations cells bypassing the dead ones. What was bad about the stem cell treatments is that they left the patients still paralyzed but now paralyzed and in pain, as if the new cells cross onnected with some pain cells instead of the motor neurons as hoped. Hard to say what would happen in the brain if the wrong connections were bridged. Probably nothing too good. Otherwise, at best, maybe relearn some function, but that is not the same thing as restoring memory.
Wikipedia Note: "A neurite refers to any projection from the cell body of a neuron. This projection can be either an axon or a dendrite. The term is frequently used when speaking of immature or developing neurons, especially of cells in culture, because it can be difficult to tell axons from dendrites before differentiation is complete."
OK. Non-clinical experiments on cells floating in petri dishes. Not even ready for rats, apparently.
http://www.toyama-chemical.co.jp/en/rd/area/cns.html
Unlike what's out there now, Anavex 2-73 actually repairs what has gone wrong in the cells and makes them better again. It's like spark plug wires on your car engine. They start falling off, it's going to run like sh*t and start spewing black smoke, clogging up. Enough of them fall off and it stops working altogether. Perhaps a picture from the corporate presentation makes it easier to understand. You see how the molecules on the keft have become unzipped? Anavex 2-73 zips them back up again. That's why it works better than anything else being tried.
http://s32.postimg.org/kuy4xdnet/endoplasmic.jpg
Nice touch, color highlighting and underlining. And the three exclamation points at the end really got me convinced. lol
re: "What do you think about the Alzheimer's drug trials failure rate? "
It means that Anavex will have a multi-billion market all to itself when it displaces all the crappy failure drugs with something that works and becomes the new standard of care. The confirmed value of Anavex's intellectual property will be in the billion dollar realm and profits from commercialization will be substantial driving valuation and share price north of $25 .
Well, that's what I think. :)
Yeah, link didn't work for me either.
I expect that it will echo what some of us have already known. To me, this is the best junior since finding goro, years ago. I'm up big time but can't bring myself to trim any so far, even though pull-backs in gold are to be expected in the course of it's new uptrend.
Look's like somebody decided to lighten up a little today. Oh well, expect they'll be back along with a lot of new investors before too long. Even if gold doesn't peak to great height like it did in the goro hay-day, it still looks to be pretty darn good. imo
Things could get "interesting" after the election, depending. Either of the democrat candidates will likely continue with the more or less liberal economic policies we have now. But, Trump otoh, has, in effect, threatened default on treasuries, though he periodically tries to reverse himself when the implications of some of his more bizarre statements are called into question. He also seemed to think "printing money" as a way to monetize our way out of debt could be some kind of solution. Talk about flight to safety if that happens. I saw an article theorizing that he is secretly pals with the Clintons and is deliberately acting like a buffoon to shoo voters into the arms of Hillary, simply because she is 'not Trump". Bizarre.
So, the future looks either more-or-less good for gold or possibly frighteningly good for gold. And what's good for gold is good for Lion One investors. :)
re: "Anavex clinical trial data"
We're not really waiting for data, per se, we're waiting for the results of detailed analysis.
After initial discovery of a few planets orbitting nearby stars, there was strong expectation of finding more, but uncertainty of how many more would turn up in a more extended search. NASA experts recently confirmed the detection of another 1200 or so exo-planets as a result of analyzing existing raw data on the narrow section of space being observed, but it nevertheless took them months (and they have some pretty fancy computers).
The point being that scientific analysis to establish the existance of something that is implied by a series of measurements can take a lot more time than it would if the phenomona could be experienced directly. Just like we can't visit the newly discovered planets, we aren't the people being treated in the study and able to know fitst-hand, but instead will need to rely on a studied interpretation of observed facts, by, I imagine, well paid professionals with high self esteem, who can't be rushed. :)
re: "all this was done without a single company owned microscope. "
Wait a minute... Didn't one of the bash articles say "they only have one microscope?"
If so, it's probably a really nice microscope. :)
information overload... :)
re: latest grant news $1.4 M NIH, BU & Harvard
So,was feeling a little slighted at our guys, Anavex, being passed over. Took a look at Klogene Therapeutics, recipient of latest AD grant from NIH Boston University. The website is a little weird in that one must click on the little square at the top right on to get to the orher web pages.
From original news release:
“This is a major milestone for our research. My laboratory at Boston University School of Medicine has studied the Klotho gene [...] since 2003,” said Dr. Carmela Abraham, Professor of Biochemistry and Pharmacology at Boston University School of Medicine and co-founder of Klogene Therapeutics, Inc. “We are pleased that our pioneering work has been endorsed by a generous NIH grant [...] “I dedicated the last 36 years of my career to Alzheimer’s disease research and I do not intend to stop until we have a treatment or a cure. I am more optimistic than ever that we will succeed,” said Dr. Abraham.
No mention of ipo or stock at this point. It's a private startup. Actually $1.4M isn't a huge amount as major grants go. Enough to pay a few researchers comfortably to keep going for a few years at least. The main researcher is co-founder of the company, maybe even gets a nice corner office. The colleges can now basically divest themselves from this particular project. Now it's up to Klogene to succeed (or fail), not the college, along with any impact on prestige. Evidently, they haven't quite succeeded yet. Maybe they'll announce a sudden breakthrough 100% cure tomorrow. OTOH, another way to read it is that they don't have a cure, or even a treatment, even though they've been at it a while.
Maybe, there is some awareness that maybe somebody out there does have something that works (wonder who that could be) and this is a nice way to take care of their own, out to pasture before the general word is out (e.g. confirming data) after which it could be awkward to just pull the plug.
At some point, actual success against AD could be a little rough on a lot of people who have been making their careers in perpetual AD research. We've heard the term "Cancer Inc." So far, AD has been basically in the incurable category as well. Lot's of people have been working on it, some, as here, for as long as 33 years.
Sorry, I'd rather see meaningful help for AD sufferers come to commercialization, even though it might mean some others in the field might be out of a job for a while, though I can sympathize.
Well, as a result of some rumination and reflection,that's my take on it. Don't feel so bad about the grant at the moment.
http://www.klogene.com/
re: grant
To use an East-coast expression, "What are we? Chopped liver?" :)
Its either getting slammed or it's like we don't exist to higher media / organizations.
There may be some pause given to MM who may be predisposed to excessively NSS AVXL in the future, given the recent Supreme Court news.
http://aminewswire.com/stories/510724790-naked-short-sellers-squeezed-by-supreme-court
-edit- sorry jb I meant to post this as a general new post - hit the wrong button :)
re: Anavex as Popeye
Apparently we're still in that part of the episode where Bluto uses Popeye for a punching bag. :)
On the subject of boxing, did anyone else notice on lvl 2 that lately we have been getting periocally boxed in by the stately and ever majestic MM Goldman Sachs, as opposed to the usual guys? Wonder if that could mean anything? Mount Olympus reaching down to dink around with little old us...
ref: "boxing" is where the same MM has sizable blocks on both the bid and ask in order to control the price. (unless it's pure coincidence of course)
Actually I was sceptical, which is why I checked around.
Yeah, nothing to worry about investment-wise.
It's experimental work being done out of a college lab anyway. Most likely it will be superseded by antigen-receptor therapies i.e. aka TPIV .
On the other hand, the professor guy that made the virus his life's work has been described as "obsessed".
There's this Phineas and Ferb episode in which Dr. Heinz Doofenshmirtz gets interviewed for jury duty. "So, Mr. Doofenshmirtz, we list your occupation as mad scientist, is that correct?" "No, that is not correct. I am not mad. I am evil. Evil scientist. There is a difference you see. And it's doctor, not mister." :)
https://en.wikipedia.org/wiki/Dr._Heinz_Doofenshmirtz
Obviously nobody's evil here, but all this trying to design viruses and bacteria to eat cancer kind of creeps me out a little. Maybe I've been watching too many post-apocalyptic sci-fi movies (but what else to watch when one has already seen all the space-based ones? Though I have to admit, "Twelve Monkeys" is pretty good...). Lots of plague-wipes-out-the-human-race-after-escaping-lab cinematic themes out there. Almost a cliche'. White lab coat guys: "Hey, let's cross a deadly virus with the common cold!" 'Yeah, great idea!" ...NOT
re:"The post that Apostrophe linked us to with the Forbes article really has nothing to do with TPIV since it deals with a different approach to cancer treatment don't you think? "
The article cited in the original post was of interest in regard to it describing in such glowing terms that it seemed like it could be possible future serious competition for TPIV . So I did a little research and shared what found.
They are similar in that they are both immuno-therapies but, yes, they use differing approaches. Although the original sensationalistic 60-Minutes piece implied a 100% efficacy which, if true, would pretty much supersede anything else being tried, the more balanced Forbes article points out that, in fact, it isn't true. The results were nevertheless, still pretty good and serve to further validate immuno-therapy in general.
I guess that they chose polio since it is specialized at infecting nerve cells. Although they crossed it with a cold virus to make it "safe". I don't know, viruses have a habit of mutating. It doesn't really seem all that safe, and it seems possible a lot of things could go wrong if it were applied on a large scale. And, the fact remains, it didn't help 50% of the research trial cancer patients at all.
Tapimmune utilizes (proprietary) peptide antigens to alert the immune system to bad cells, which is very effective once it "knows" what to do. It also can boost the effectiveness of vaccines many-fold, this makes it actually, anti-virus in that sense. This is the more benign and preferred approach, imo.
I wasn't as nimble but got some @0.69 :)
People are still too jumpy after hot potato magnum hunter and did a knee-jerk response and bailed at first utterance of the buzz word "restructuring". I think it's a very different case with xco. The outfit they brought in specializes in financial strategy. The dreaded "B" word didn't even come up when I searched their site. Seems quite possible we'll do all right here.
Forbes article dampens the excitement a bit:
http://www.forbes.com/sites/arleneweintraub/2015/03/30/heres-what-60-minutes-didnt-tell-you-about-the-miracle-glioblastoma-treatment/#56cedc3719aa
"Eleven of the 22 patients treated so far died, but the other 11 have seen their tumors shrink. Three featured in the story are cancer-free"
So it still effected a remarkable cure but unfortunately couldn't cure everybody.
re: "Cilantro's pretty awesome...I can never eat enough. "
Ugh. Apparently I'm in the 25% or so of people who can't stand the stuff. No matter how I've tried it, it always tastes like lemon dish detergent. Sticking with maple syrup. :)
re: "I had read all this stuff, and then I started reading about Heptares"
I also started to read up a bit on the buying of Heptares . They have developed bio-mapping techniques using x-ray crytallography that basically allows them to reverse-engineer biologic molecules. Then they can "engineer" compounds based on that knowledge. One could also include "copy" under that heading.
I think that bio-mapping technology is what got them snapped up more than any specific compound they have worked up so far. Maybe they are considering trying to do an end-run around Anavex, or at least making a show of it. Their main accomplishments seem to be determining the structure of the actual receptor molecule inside the body so they can recreate it. The trouble, if I understand correctly, is that these natural molecules are unstable and don't "keep" very well outside the body, so their goal is to "tweak" them into a more stable version. But, if you want to make a pill, there is the hurdle of the gastro-intestinal process transforming the compound into something else, still some chess moves behind. The bioreceptor chemistry is incredibly more complex than I ever imagined.
https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor
I think anticipating what happens to an externally introduced molecule as it finally makes its way into the brain is like trying to predict the outcome several moves out in a game of "go". They ostensibly have something more-or-less ready for M1 but I wonder if it would need to be administered intravenously. The Anavex compounds actually improve as they transform and already can be taken as a pill. Anyway... way ahead.
re: "So when one asks who does the low share price benefit? One answer would be long investors that are actively accumulating. "
You're right. Thanks for the uplift. There's usually an upside to everything even if it's not always readily apparent.
re: "I took "interesting" to mean "unusually borrower-friendly for LP". "
Touche' ... Hey, I was on a roll. :)
It's still bad enough though even without extrapolating.
Questions for all to consider:
Who benefits from the coordinated attacks, sinking the share price?
Do the profit margins associated with collusion outweigh the potential profits gained from conducting business in a legitimate manner?
For those of us for whom the answers seem pretty obvious, we just need to keep remembering to look past the smoke screen and not be hoodwinked.