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he trades on margin and keep getting margin calls liquidations from his broker every time there is a down turn
AF and Jesse getting ready for Dec 1st
"This $AVXL presentation is going to be fascinating engineering exercise. How high can you pile bullshit before it topples over? My guess: REALLY HIGH! With all this lead-in time, Chris Missling will be wearing an oxygen mask."
"I’m expecting an edit of Primary Outcome measures on ClinicalTrials shortly??"
no Bloomberg, just have it on my charts as something to watch for. I used to have a screener that I had made for IB but I only use TOS since I don't use IB anymore.
pretty sure a 9 count will print today at the close on the XBI, and with it being a 52week low, that set up for a nice reversal tomorrow.
not really, it's only on a 3 on both (9 and 13 count), and if the 9 count prints it will void the 13 count. I tried to insert a chart but can't figure out how to add it to the post.
On TD TOS it's only a showing a 3 count after a 9 count so far, so still got a long time before a true 13 count reversal from what I see.
I think the 94% was in reference to PDD and not ALZ
yes, been following them for about a year and they have a lot of preclinical data that looks good. Their MOA is unlike any other drug company. NVG-291 has shown in rat models that it can modulate the PTPsigma receptor and allow nerves to repair themselves and regrow new connections. Lots of promise for AZ, MS and spinal cord injury. All 3 which they are going into trial beginning in 2022. Dr. Jeffrey Cummings is also on the advisor board. Still a small, not well know company since it's a small Canadian company, but the technology is from Dr Jerry Silver from Case Western University. Looking to uplist on Nasdaq sometime in the future as well.
another one that was out today along those same lines
https://www.sciencedirect.com/science/article/pii/S2589537021002686
has there been any info released from the PDD trial on the gut microbiome data yet ?? like the before and after ?
Change in a blood sugar would be a monster, I've always wondered if they were tracking these other stats on patients
Shining new light on the actions of key neurotransmitter in the brain
Summary: GABA can selectively regulate the excitability of neurons.
https://neurosciencenews.com/gaba-neuron-excitability-15786/amp/
Is that a +5.5% and a +6% ? Did they double down ? or is that the same lot of shares ?
Scientists Now Know How Sleep Cleans Toxins From the Brain
https://www.wired.com/story/scientists-now-know-how-sleep-cleans-toxins-from-the-brain/
Epilepsy Patent
a while back someone posted the link about the a2-73 patent application for treatment of Epilepsy where it listed out where it could be used in combo with some of the existing drugs and a single outcome for each. Could someone post that link again. Talking with a friend of mine with Epilepsy and we were looking for the name of to see if they are anything he has been prescribed in the past. Thanks for your help !
maybe they have been waiting on the fast track designation from the FDA to announce the US arm of the AD trial. Guess we'll find out either way soon.
Why is the fake news about "Park West Asset Mgt SOLD all IMHO" the top PIN ?
Might have been Acadia Pharmaceuticals Phase 2 for trofinetide ??
Don't think should give anything away on the cheap, Japan is 2nd largest bio-pharmaceutical market in the world and it is projected that by 2030, 1/3 of their population will be over the age of 65. Japan could be a huge market for AVXL.
Goldman put a value on BIIB Az drug @ 12 bill
it's part of the proxy vote: not official yet though
Ratification of Independent Registered Public Accounting Firm. To ratify the appointment of BDO USA, LLP as the Company's independent registered public accounting firm.
I think another good sign about planning for commercialization, the hiring of BDO with Offices in 162 countries, https://www.bdo.com/services
Lack of sleep is tied to increases in two Alzheimer's proteins
https://www.sciencenews.org/article/lack-sleep-tied-increases-two-alzheimers-proteins-brain
not sure if this article was posted here last week or not
Update of all three
here are a couple of those 32 from the P1 trial that were on the news in Australia, not sure if they have been posted here or not.
How many of the original 32 are still taking the drug today ? If this has been discussed I must have missed it.
"Lastly, the development of new and more powerful antioxidants that also stimulate mitochondrial biogenesis are likely to be beneficial for carriers; these include idebenone and Anavex 2-73, and controlled trials for these treatments are needed"
https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00564/full?fbclid=IwAR0SV2yARIxzZpcAGK7xekcULKUe-Bjk24OMnai7q0ZkESuyItb1rWXBY1E
Market Maker signals from one MM to another
100 = I need shares
200 = I need shares badly, but do not take the stock down
300 = take the price down so I can load shares
400 = keep trading it sideways
500 = gap the stock. This gap can be either up or down, depending on the direction of the 500 signal
911 = pending news
666 = anytime you see NITE print 666 at the end of any trades, dip time, JMVHO-GLTA
Anyone ever seen this ? wonder if it explains why we see weird size lots go through on AVXL all the time
could it have been naked short covering ?
gotcha, thanks for the input. Allot of input in that documentary about to how the FDA works on approvals for medical devices and drugs, after watching will truly make you wonder
I just watched a documentary call "The Bleeding Edge" on Nexflix and in it they were talking about some elderly patients that had gotten hip replacement with metal ball and socket. One Dr that had the same surgery started having neurological issue and after doing some test on himself he figured out he had Cobalt toxicity from the metal used in his hip replacement. Long story short, allot of his elderly patient in his practice started having issue that were being diagnosed as early stage Alzheimer's and Dementia. Only after the Dr started talking to the patients did he find out they all had similar hip replacement surgery with the cobalt components. He also realize that these patients with A&D type symptoms were probably bing misdiagnosed. I wonder if any hip replacement patients like from this group might be in any kind of A&D studies or if anyone is looking out for anomalies like this, which would obviously have an unfavorable outcome in a particular study.
here is that panel discussion
Alex is on the BOD of BIIB so doubt he would help much
Here is another youtube video with Dr M. and 2 other, kinda long but it's nice to get his insights on the bio/pharma industry, and you can understand some to how he seems to be doing things at AVXL. One interesting insight was his thoughts on selling or partnering too soon and leaving a lot of potential upside on game changing technology where his investors miss out.
here are a couple of those 32 from the P1 trial that were on the news in Australia, not sure if they have been posted here or not.
do yourself a favor and look up these two co-founders on youtube and check out what they have done in the past, Dr. Bob Hariri and Peter Diamandas. You will really start to see how much potential value SRNE might gain from it's 25% stake in Celularity