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It may be that Merck, as should the other BPs, is coming to the realization that the future of oncology will heavily rely on immunotherapy versus chemotherapy, and that enabling the immune system to recognize and attack cancer cells in particular is in harmony with the function of the immune system.
The same immune response mechanism along with poly iclc and other adjuvants summon up higher numbers of non-exhausted T-cells to the tumor sites, which is key to efficacy and enables combination treatments to work their attack angles in a more favorable battle against the tumors.
It’s like having fighter aircraft and attack helicopters strafing and shooting missiles at an enemy offensive site to soften and hamper the enemy site for the ground forces to neutralize. The ground forces alone might not succeed against a heavily reinforced and armored enemy site, but with the general air support the enemy site could be heavily weakened.
The target enlightened immune system bolstered to produce and direct tumor signature seeking T-cells in significantly larger quantities than usual for individuals afflicted by a cancer (and especially those who have undergone chemo/radiation) and provide breakthrough benefits, and in combination attacks provide extraordinary responses.
Yes, I agree that DCVax has the potential to make other treatments work better than either alone and is the necessary component of the combo treatments!
Upon approval of the MAA, and confirmation of extraordinary response to the DCVax/hiltonil/keytruda combo, whether licensing, partnership, or just a symbiotic relationship such as the remora fish with sharks, nwbo will do well.
The question might become: which is the remora and which is the shark, keytruda or DCVax?
So a cabal sets up to turn a very positive event into a deep dive, using hit pieces and spreading those around, and all that to cover the main event of manipulating the sp down drastically and scaring most weak hands out, and that’s all nwbo’s fault?
Sh-t happens and LL couldn’t be at the event. The data presented was positive.
The smoke screen and alleged spoofing did the dirty deed, and it was done dirt cheap
AF has damaged his brand imo.
His hit pieces don’t have the response they used to have, however the cabal still plays off them and try to use them as was done May 10th imo.
The truth is more accessible than it used to be with information sources such as searches and this message board.
Also, you make a few bad calls and it brings into question what facts were brought to bear, and lacking firm information one’s credibility is called into question.
Keep focused on the primary near term goal!
The rest of the stuff could be updated and made nicer after approval!!!
Thank you very much!
Then in a sudden change from all the FUD that stinks to print, and the easy rebuttals since the recycled FUD has been debunked numerous times already, the question is asked:
Does the MHRA update the approval database potentially every day, or are there certain times of day and days of week?
Curious whether I should anticipate approval each and every day from here on, or are certain days or dates predetermined?
I’m looking forward, not in the rear view, to the destination and not where we have been. Been there, done that!
As dear Ronnie Regan used to say (or was it good ole John Wayne) “wagons ho!!!”
Another long in the Peach State!
Hope to celebrate with y’all soon!
The longer run depression of the sp aligns with the large shorts and probably much larger naked shorts positions. Driving the price down makes for more gain when shorts cover, and the most gain if they can bk the company.
Yes that would give retirement a huge boost and the dividend goes up over time!
Sometimes you can get to one of the mets and get enough tumor to make DCVax vaccine from. For example my mom had many mets in her lungs and they were able to guide a needle biopsy to one of the tumors.
Unfortunately her oncology team didn’t pursue DCVax ( this was about 5 years ago) but rather genetic sequencing to determine plausible drugs given her tumor genetic profile. These various drugs would shrink the tumors for a while but the tumors would eventually increase again.
Anyway I wish I could have had them try DCVax but they didn’t even freeze the initial primary tumor.
Good luck to all of us longs!
Good luck to all those who may need and benefit from DCVax treatments, which may be a whole lot of people given the statistics.
We each know a number of people, friends and relatives, who’ve experienced GBM, and many who’ve experienced solid tumor diseases. DCVax offers great promise and dignity with essentially no side effects and ease of administration!
I don’t have the cohones to jeopardize my wife and myself in retirement, but truth be told, not even during my career.
Still, I did invest enough in nwbo stock to be painful if lost, and secure a high degree of financial security if all goes well as we long’s believe. Not enough for a megayaht or my own private jet but probably enough to charter yahts and jets, and help/leave the kids a nice legacy.
That’s just me, not putting everything in any one investment, but nwbo is far and away the biggest single investment in a small cap pre revenue company stock, but the risk/reward also appears to be a once in a generation opportunity, especially as the milestone dominoes have been knocked over greatly derisking the investment with the next milestone being approval based on demonstrated efficacy and proof of manufacturing, distribution, and administration of the treatment.
So maybe I won’t become a billionaire or even a tenth of that, but 7-8 figure millions ain’t chopped liver
Hopefully some of you all-in folks will invite me to party on your megayahts and jaunts on the jet to Monte Carlo
Get your facts right please!
The results are not dubious and they are being more widely validated each day.
The company is not insolvent and will likely begin to grow revenue with the expected approval.
But you know this already and just spew FUD.
The share price will be what the manipulative game plan controls it to be, both up and down.
Until the manipulation is rendered broken the share price is artificial, period, end of story.
So while i realistically accept that the market for nwbo is rigged, i also believe that the grip will be broken and truer value will realized, and i believe this will happen this year and sooner than later.
When the share price is artificially low as it is now I try to pick up more shares.
That’s my game plan however I don’t sell shares and play the sell somewhat higher to buy back more when on sale. Too much work and fear of missing out when the big move comes.
Opportunity to pick up less expensive shares if one is inclined to increase their Nwbo position which is a personal choice imo.
It is pointless to keep debating whether nwbo will or will not PR acceptance/validation because it’s a fait accompli given no rejection of the submitted MAA.
Each day is a day closer to approval!!!
I’m guessing approval comes well before 150 days given DCVax PIM status, the specials program, the manufacturing license, and the dire need to get the treatment to all the patients!!!
March-April if not sooner is my guess.
Your fact gathering is seriously flawed but you knew that!
The submittal was PRed, and no follow up stating any form of rejection!
As previously posited, non acceptance would have been made public by now imo, therefore acceptance/validation is a tacit assumption at this point logically.
We are still heavily manipulated so sp is artificial until catalyst to break the grip.
Apparently you chose your moniker of John Bull well because you spew the bull!
So obvious your intentions are to cast FUD imo.
If the sp goes lower I will exit some other positions to buy nwbo at firesale prices just before likely approval!!!
Agree 100% regarding likely omission of Temodar in the future, which is why I think Merck might want to position to not lose out by having other parts of the combination treatments, and possibly influence the timing of Temodar’s retirement from the GBM treatment regimen.
Nothing wrong with partnerships going forward regardless of water under the bridge.
You keep dreaming and spewing falsehoods.
We’ve debunked that recycled FUD several times already.
That little farce wouldn’t fool a Corleone
If I were running nwbo I would go the partnership route with multiple partnerships and possibly licensing. I think DCVax value would be greater in a sum of its part(nerships)
I think Merck will not burn bridges and will create bridges. Merck not only has keytruda but also has Temodar (sp?) as part of current standard of care, and the phase 3 trial administered DCVax in addition to the SOC radiation and chemo.
So these three (Temodar, keytruda, nwbo,(poly iclc)) can have symbiotic and/or replacement relationships. If I were Merck, I would want some control/influence over the paths and relationships and be positioned for the potential outcomes.
How to accomplish this may have to play out like a chess game however Merck should not be a bystander in the field.
Full disclosure, in addition to nwbo I have a relatively much smaller position in Merck just as a big Pharma holding.
Yes, it would be great if the settlement incorporates such means to deter at least some types of shenanigans going forward!
The judge seems to have done his homework for sure, and although I agree it would seem an open and shut case, I suspect the judge has to read out impartially however he identified a weakness in the complaint and how to modify the complaint to avoid a granting of the MTD.
Imo this readout was beneficial to nwbo’s case for ultimately denying the MTD, setting up eventual settlement because the MMs have too much of a good thing to risk airing the dirty laundry publicly, and just get on with business pretty much as usual.
Agreed that the lawsuit isn’t the main event, approvals and collaborations are the main events!
The law suit is also important because:
A) it might provide big settlements to bolster nwbo balance sheet (no bk threat) and fund trials, research, and broadening indications, and aid uplisting
B) shine a spotlight on the MMs’ shenanigans and possibly get some relief from some of the shenanigans, while exposing the shenanigans and possibly encouraging other companies to follow suit (pun intended)
C) possibly encourage the SEC and Justice to police the markets better, but the big MMs have friends in high places and the big bucks to influence. Let’s face it, influence can be curried for relatively small amounts so large amounts can materialize strong support. Imo it’s not that the SEC and others are getting greased, rather it’s possible that job security and budget allocations might be the concern. After all the thinking might be that if position and/or budget is lost, then the rest of the good stuff is jeopardized, perhaps?
In summary, the suit can be very important however the approvals and commercializations are job 1 imo!!!
As Cramer says, You’ve got horse sense!!!
All sound points and logic grounded in reality.
The only thing I might add is in the MMs redefining their “value added” I’m inclined to guess they are so used to the easy money from questionable practices that they will pare down the easy to prosecute shenanigans and concentrate on the harder to prosecute shenanigans. They probably feel they “are” the market and with their power and money corrupting absolutely an entitlement psychology dominates imo.
The MMs can bail by offering a settlement so they can continue business as usual.
The MMs can also choose to change sides and go long nwbo after covering their shorts.
Will the MMs do these things?
Now if the MMs offer a settlement and Nwbo rejects it, things can get full contact mano a mano!
I’d guess rather than fight the Wall Street equivalent of WW3, nwbo would take the big settlement and as LP once said, use it to fund the expanded ongoing DCVax platform efforts.
Not to mention pay a decent dividend each quarter to us retired and non retired shareholders!
I hear ya!
My father in law keeps urging us to travel and enjoy these “younger “ years while we can.
Interesting analogy as I do tend to tear up looking in the mirror
I’m a firm believer that age is mostly just a number best not to dwell upon,…… except when you get those hip joint pains that come and go to remind you