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No true longs sold into this fiasco. This was a coordinated take down by the cabal using their own cheaply acquired shares to paint a picture of failure. This is a mirage and when the market wakes up watch out because true buyers will come back in and buy up all of these cabal shares.
I am sure NWBO is watching. This is a clear attack by the cabal and MM's on uniformed retail shareholders to try and dislodge their shares to cover significant short positions.
NWBO's handling of TLD release to such a small subset of people has in itself created this fiasco.
Now that the blinds are off let's see what NWBO do about this fiasco. I expect large buys to start rolling in at some point.
Goes to show that the cabal are indeed real and have for years accumulated bucket loads of shares to dump on the market at any sign of good results. Today they are dumping their cheap shares to panic the market so they can cover their short positions. This is a blip and will not last and NWBO will start the marketing going and these groundbreaking results will have the impact they deserve.
100% agree, nothing wrong with swing trading a portion. Sounds like his intention is not to do that and buy back sub $1 which I do not believe will happen.
Unfortunately for you this is a very different day. Good luck with your profits, you can buy back later at a higher price but never mind because this will still be the best investment for many years.
Fully deserved MID, your positivity has been a shining light on this board for so many years and thanks for compiling your DD into such a positive and uplifting message.
I have been sitting back with my wife just enjoying the show these past few days and like all of us longs on this board looking forward to the rise of NWBO. It will be magnificent.
Sojo, you are one of the many longs that have continually sought to bring positivity to this board and your charts have been an education to so many of us. No need to apologize because we know where your heart lies and we appreciate you for that. We will continue to rely on yours and Judges charts as we enter a new phase where the waves will be higher and the chances to expand our shareholdings will increase. So keep up the great work and I look forward to all the charts to come.
Hey Flip, it has been immensely frustrating at times and I can fully appreciate the angst you feel toward NWBO’s handling of its shareholders over the last number of years. When reviewing your fine piece yesterday and with hindsight it becomes apparent that the carrot dangling employed by NWBO was their attempt at survival not only for themselves but their shareholders. We as shareholders have been left frustrated many many times over the years but our collective belief in the science and Linda Liau have enabled many of us to build a nice chest of NWBO gold.
I firmly believe that we have seen the last of NWBO’s carrots and Bosch talking at ASCO is not just another carrot as this would be a blow to low for many. Their silence has been long but at least not filled with carrots so let’s all take a collective sigh as we await the curtain raise and finally for the great show to begin.
Thanks again for all the DD you have provided to this board and I hope you are fully rewarded for your extreme patience. The battle has been long but our victory will indeed be sweet, and that victory will bring relief to a world filled with hope for such a treatment that will save so many over the coming years.
Many thanks for your continued excellence on this board.
Just goes to show how invisible NWBO and DCVAX is to the world. When the news breaks you can expect a massive reaction to all those that are blind to this. Storied stocks make their own waves and one such as this will make rather large waves.
I think most knew this was a pipe dream as NWBO intend to release TLD followed by top line journal. Bosch can talk about DCVAX during the expert theatre after TLD and journal. An abstract was never getting released ahead of a journal. No one is getting disappointed by this except those wanting to make a mountain out of a mole hill.
You could always send him a message to his LinkedIn account. Not sure how much you can include on your introduction though.
You just cannot help some people.
It seems in todays society that it is acceptable to deceive and misinform with absolute impunity. There was a time before the cloak of anonymity when we would take care when sharing an opinion in an open forum and make sure that any facts shared were well sourced and researched and to the best of our knowledge truthful. In todays world we see blatant lies from our politicians and news stations and when the leader of this nation is allowed to stand in front of the world and openly lie what hope is there for the rest of us. It seems that in the world of the internet getting a lie out in front of the truth is the aim, because once that lie is shared, to many it becomes the truth.
NWBO seems to understand this and are setting up there stall to make sure that the truth above all else gets ahead of the lie once TLD is revealed.
AF and his ilk may choose the side of the lie but in this case the science will prevail and scientists such as LL will be the truth that sets us free.
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The following are all current UCLA Brain SPORE research projects.
PROJECT 1
The lack of effective treatments for glioblastoma (GBM) patients remains a significant health problem and highlights the need for novel and innovative approaches. The broad overall goals of this research project are to investigate mechanisms of immune evasion following active immunotherapy, and to develop rational combinations of immunotherapeutic strategies to overcome the immunosuppressive milieu of the brain tumor microenvironment. We postulate that clinically relevant anti-tumor immunity to glioblastoma (GBM) must have two cellular components: 1) significant infiltration of tumor-specific tumor-infiltrating lymphocytes (TIL); and 2) blockade of immune-regulatory antigen presenting cell (iAPC) function within the tumor microenvironment. As such, our hypothesis is that the local cellular interactions between iAPC and T lymphocytes within the brain tumor microenvironment is a critical factor influencing the efficacy of immunotherapies in glioblastoma patients. A better understanding of the biology of these cellular interactions will provide insight into more effective ways to induce therapeutic anti-tumor immune responses for this deadly type of brain tumor.
In Aim 1, we will study the mechanisms by which iAPC limit glioma-specific anti-tumor immune responses in vitro and in vivo.
In Aim 2, will we evaluate the efficacy of combining tumor lysate-pulsed DC vaccination (to induce T-cell infiltration into tumors) with immune checkpoint inhibition and other novel immunoregulatory targets (to block iAPC function) in pre-clinical syngeneic animal models of glioblastoma, and explore the use of a novel PET tracers as non-invasive imaging biomarkers of immune response.
Finally, in Aim 3, we will develop and validate predictive tumor, immunological and imaging biomarkers of response in recurrent glioblastoma patients enrolled in a Phase II clinical trial of DCVax-L +/- PD-1 blockade. These studies span the continuum of translational research in brain tumor immunotherapy, and will likely provided informative new insights for the development of new, rational immune-based strategies for brain tumor patients.
Extremely positive DD regarding Flaskworks which has always been critical in my mind.
Looks like we are a lot closer than I thought. Any announcement regarding positive ground made with the EDEN project which makes commercialization a real possibility will send the SP soaring. SOC will become a reality for the DCVAX platform which makes the ASCO title even more intriguing.
Could just be WLHTB getting back into NWBO. He has talked about getting back in over the last couple of weeks.
I think you are right there, not looking good for JD. Meanwhile a potential suitor in Merck has for the past month slowly risen. Steady accumulation maybe. Any partnership announcements for the next potential SOC tech will be a boon. IMO
This is the exact answer I got when querying DI regarding our musings last month. I to am hoping that step 2 is complete because if not then there is an issue with the technology being able to replicate NWBO’s method which would be a bigger issue which would force LP’s hand to approach commercial manufacturing a little bit differently and at much higher cost. This seems to be something that she has always wanted to avoid and could be leading to delays in announcements regarding TLD and publication. IMO
You forget that if this becomes a storied stock because of stellar results then it wont matter what the market is.
Thanks Bio, glad to know that CRL is still an option and I understand that the Flaskworks EDEN project once approved is a gateway to production on a grand scale which opens the pathway to DCVAX being recognized as a platform technology in both L and D.
Bio, question for you. What happens if they cannot execute with the EDEN project. They have not yet reached the second milestone and I believe LP put too much faith in this device and may have been hoping that she could bypass CRL. If LP has to go back to manual manufacturing how long will they need to delay in order to be ready for GBM only if CRL need to prepare the ground for approval. Memphis has in the past been an area of interest for this board with regard expansion but I do not believe that has kicked off yet.
My belief is that manufacturing readiness is now the primary reason for delay and everything depends on the success of the EDEN project.
Thanks Flip,
Let's see what the company response will be and I agree that Ex's reply was indeed weird.
I would suggest that as many people as possible pressure the company in revealing the current status of the EDEN project because this is a very critical piece of NWBO's grand plan.
I think that this is something worth pursuing.
I am wondering if certain parties have been privy to this timeline.
OK so in regards a timeline NWBO should have received a detailed timeline as to when this system should be ready for commercial use. From the 10K
A)delivery to the Company by Recipient of a document listing all technical and regulatory requirements for the deployment of the EDEN system to manufacture DCVax-L, together with a detailed timeline;
I wonder if NWBO would share this timeline with investors.
Flip a quick question.
There has been a lot of talk about Microden but very little about EDEN which is the large scale producer of DC's.
Here is some material I found regarding EDEN and MicroDen.
I would assume NWBO also owns the rights to EDEN.
If we are all aware of this please ignore.
From Article:
Correspondence: Shashi Murthy (s.murthy@northeastern.edu) Background
Dendritic cells (DCs) are effective vehicles for personalized therapies and there is substantial interest in leveraging their capabilities for improving patient outcomes [1,2]. However, the process of generating these DCs, typically from monocytes (MOs), in an efficient and reproducible process has proved challenging. We have developed automated closed systems, EDEN (large scale) and MicroDEN (small scale), for generating clinically relevant numbers of DCs from precursor MOs which can be sterile-transferred for downstream applications. These systems overcome many of the constraints of manual processing and are designed for the research environment as well as clinical manufacturing.
Methods
Enriched MOs were seeded into EDEN at a density of 206,000 MOs/cm2 using RPMI 1640 medium supplemented with 10% HI-FBS and 500 U/mL IL-4 and GM-CSF (R&D). Medium was continuously perfused and immature DCs were harvested on Day 6.Enriched MOs were seeded into MicroDEN at densities of 200k, 400k, and 600k MOs/cm2 using CellGenix DC Medium supplemented with 350 U/mL IL-4 and GM-CSF (CellGenix). Medium was continuously perfused and DCs were harvested on Day 6.
Results
Flow cytometry indicated that immature DCs (iDCs) from EDEN exhibited standard DC-SIGN (CD209), CD14, and CD80/83/86 (Figure 2). Antibody expression is comparable to prior results collected in MicroDEN and well plate controls. Approximately 25 million viable iDCs were harvested from EDEN for an iDC yield of 32% with the relatively low seeding density. These results indicate that EDEN can be used to generate clinically relevant numbers of iDCs in a single closed system. Flow cytometry indicated that MicroDEN generated phenotypically similar iDCs at each seeding density with an iDC yield of ~30% (Figure 3), similar to well plate controls. Allogeneic functional assays indicated that MicroDEN iDCs exhibited improved proliferative activity than well plate iDCs and generally exhibited better activity at lower seeding densities (Figure 4).
Conclusions
DCs generated in both EDEN and MicroDEN are phenotypically comparable and exhibit increased proliferative activity to standard manual culture. Upto 26 million DCs can be generated by MicroDEN at the highest seeding density whereas the output of EDEN is 26 million DCs at the lowest seeding density.
Blind trust in authority has been a key tool utilized by Governments and MSM the world over these past few years. Litigation has been a useful tool to try and curb this exploitation of trust but even that is being dented by the ever increasing wealth and power of this minority element. A good example is the release from litigation for all those BP’s that have been involved in Covid vaccines. You would expect them to answer to any serious side effect some may have considering the enormity of profits they have made all through tax payers. Blind trust is closely related to effective brain washing. In this day and age thinking for yourself often labels you as a conspiracist and can lead to the cult effectively canceling you. Who lies loudest seems to be the tool utilized by MSM as well as our esteemed leaders. What a sorry world we inhabit these days. Hopefully NWBO can effectively maneuver through these ever increasing muddy waters because as we all know a lot of mud is going to be thrown in their direction if their technology threatens the status quo.
BP after all loves sick people and as we know NWBO is looking to cure them.
Flaskworks progress should not be a secret at all. They are now almost 18 months post buyout of this technology and you would think that we would be updated by now on the success or failure of this vital piece of tech. I do know that it is not being tested alongside the current batch at Sawston so it must be very much a work in process. Why it is taking so long to progress this tech is anyones guess because as Flip states they have gone silent on this to.
Agree 100%. Flaskworks is critical and the only way that LP's dream of a platform technology becomes real. I believe the whale needs MHRA to certify Flaskworks before any deals are signed. Flaskworks certification will send the SP parabolic because we all know what is coming next.
Can you confirm that DI actually told you that finding peers to review the journal is the holdup. If again this is speculation then you are really pushing for an SP meltdown by making it sound that incompetency rules within NWBO. I seem to remember that 100's of scientists signed up for the previous journal some years back now. Now all of a sudden there are no scientists out their willing to be peers. Comedy central on this board.
This would be the perfect time. Imagine all those investors cashing out in a bearish market and out of the blue a brand new tech is released to the world. Money would flood into NWBO considering it would be the only bit of beautiful news released to a world population desperate for something to brighten their days.
Nothing better than true hope released to so many people desperate for their hope to be fulfilled.
What you both fail to understand is that manufacturing has always been the Achilles heel for this enterprise and I believe LP's vision was to see DCVAX take its rightful place as a platform technology. She has talked about platform technology for many years and had we had her foresight regarding manufacturing we would have known that until a solution was found gaining platform status was a pipe dream. The beauty now is that we are close to a solution and this will translate to an exponentially different valuation moving forward. The price of your shares will be based on completely different targets compared to those that the bears were hoping for with regard the manual process and the limitations that come with that.
Good luck to you both but my thinking your luck is about to change.
Spot on Flipper. Most of the space has been left open for rapid expansion of Flaskworks once approved.
One of the biggest bullish signals was when the company announced the start of manufacturing of specials for a single patient. Some shorts may have taken this lack of patients as a negative sign but for me this indicates how close we are to the point where patients in the UK will be able to get reimbursement from the NHS.
Something is brewing and I believe Dr Ashkan and the many patients awaiting DVAX-L are in the wings ready to receive treatment as soon as the floodgates are open through TLD/Journal and quick approval in the UK.
< 1% let’s get real. When top line hits this will be trading in the 100’s of millions.
You would hope that for any peer reviewed article no matter the publication that there are time constraints given to those selected peers to make sure their review is delivered in a timely manner. If they do not meet deadlines then you would hope for some controls in place to prevent deliberate stalling. It would be nice to know what type of deadlines are given to these peers if any at all.
Gary, I am surprised because I would of expected you were a lot more versed to the science of Direct which will show efficacy a lot sooner than 3 to 4 years. There are many newcomers to this board who need to do a little more DD to understand what truly will be possible once the scientific world understands the effectiveness of L on the hardest to treat cancer. Once approved as SOC for GBM the pathway to being recognized as a platform technology will be swift. D has always posed the most fear to the hegemony of BP but in the end it will be the technology that truly changes the world of oncology as we know it.
Thanks Flip for all you have given this board and let me just say that you have been a shining light for so many. I hope you find some peace from severing your mind if at all possible from what has proved a long long battle. Maybe after resting and reflecting you will also be rewarded with what we all believe will be hope fulfilled for so many desperate patients all over the world. Cheers for now.
Understand all you are saying. I was referencing total dollar amount of Novacure when they reached over 200 putting them at 20B plus for a technology that is not widely used and will never be the story that NWBO will be if the technology turns out to be what we all believe it will be. Storied stocks have completely different market valuations.
Please explain the valuation of Novacure when it was reaching over 200 dollars with a device that is barely used. I think you need to look a lot more into the science because as LP has said for many years DCVAX is a platform technology. Your valuation is poor and I hope not too many longs with good knowledge will be fooled into believing that this technology will only be worth up to 7B over the next 2 to 4 years. When the world realizes how quickly L will be recognized as a platform technology and also realize the potential of D well you tell me what happens then. We are talking a paradigm shift in how all cancers are treated.
Deepest condolences to you and your family. The loss of a loved one never leaves you and their brightest memories live with you forever. May the comfort of those memories help you and your family through this painful period and here’s to hoping that DCVax helps prevent such tragedies in the near future.