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Curious on BIIB likelihood of PR action-reaction to WSU report on 10/27? Recognize it is still a few days away but will they be commenting or not since previous connection to AVXL has been mute? That whole testing/silence sequence is a big gap IMO.
God bless
Irish...FWIW, I have RA (mild and in control) but I attribute my RA to years of drinking Budweiser, now I drink occasional Coors Light and I am OK/cured. Not saying it will work for every guy but my theory is that everyone is born w/a Budweiser counter which starts ticking down w/each one they drink. Trouble is, we do not know what the counter is set for. When you hit your number you will get a splitting headache which gets worse w/every Budweiser you drink. Coors light, no head ache....I am also Irish BTW
T-38. Agree and thought a similar thing, they have to get a handle on remyelination or they have incomplete solution.
Falcon...thanks for sharing. If I knew what you know I would not be able to sleep at night.
Pete...Eventually this is all about knowing enough to ask the right questions. That issue (of course) understanding enough to be able to create/ASK the right question is what the whole AI thing is all about. This is what Dr. Perry and others are poking at when they investigate trials/results. We can see why Gottlieb and others want Dr.M. in the room, he has fewer things to lose than BP.
W/O excellent topical knowledge a proper inference engine cannot be constructed. IMO, this may be why our trials are so important. In case of RETT the goals were (I guess) more easily understood on some scale of priorities, which must be part of the resource decision tree. We have to know enough and care enough to ask the right questions else the whole process of learning fails. That is what is happening here and why AVXL is different, IMO. It is the kind of thinking that raises Homeostasis as a CNS target question.
pete...great thoughts-questions.
Wording of scope is a lot like AVXL...agreed same turf/composite thinking also ref to regeneration as in the video PR they previously posted but is now gone.
BIIB to cast wide MS net...many interesting comments to review here...opinions welcome...
https://finance.yahoo.com/news/biogen-confirms-commitment-tackle-multiple-113000634.html
Xena...brings to mind the old expression, "just because you are paranoid does not mean they are not after you". I do not get it. Who is doing this and why? Are they individuals/part of a crew? Do you think it is possible some alt avxl set is at work or is this just random?
Thanks speramus ...can you post here pls..
It appears Dr. Perry has been swimming upstream against the popular flow for a long time. He is exactly the kind of guy we need to advocate strong P2/3 analysis. It all fits.
So, now we wait for tech/med conference outputs on 10/27MS, 10/30PD, 11/4PK/PD(AD), 11/13RETT,11/14AD. And we await corresponding PR's, and possible deal news ref MS-BiiB...other? Need news of course.
What am I (we) missing? The medical need is so great and the AVXL potential seems so massive, how is the SP consistent with all this? Many here have gone above and beyond to connect the dots. The stories seem cogent and clean enough. We have even seen the Alt-State Plaque guys folding their tents while openly admitting failed trials/results. Even the FDA is rethinking how it does trials which we appear to be aligned to conduct. I guess this is the part where we wait to learn more about what we know/don't know.
I am a believer but am challenged as a waiter.
dado...an example from Dr. Perry of a guy seeing BOTH the forest AND the trees.
Could it be as simple as these people do not want their names associated w/old school thinking in MS solutions? Example, who today would stand up and admit they were a big amyloid plaque sponsor on AD remediation? No one. BP cannot get away from this whole episode fast enough while they see A2-73 is about to make them look stupid.
bas...they must be humiliated. Now what do they do after being so wrong for so long?
So, Dr.M putting the emphasis on P2 puts the pressure where it belongs, they seem to now admit that.
ben...Nor have we had any proof that the A2-73 CNS Homeostasis restorative/regenerative efficacy thesis is invalid. W/RETT and PD trial proof that claim is potentially validated. That is when it hits the fan, IMO.
low volume ++ price action this A.M.. Does that signify anything to those who understand such? Considering the number and significance of already published near term events I see a $5 in our near term future. We are due.
Thanks....the plot thickens then...stay tuned...eventually any significant news will reveal
Would this be the kind of information/data likely to be discussed by WSU and others on 10/27?
twiz..thanks
bri...thanks
CTAD Nov 4, 2017 program-?
I have looked around and cannot see AVXL, anyone?
http://www.ctad-alzheimer.com/files/files/CTAD2017_PREPRESS_12OCT2017%20LIGHT%5B10901%5D.pdf
Power,
dado...you would likely enjoy reading Dr. Senge...."on systems thinking"
Chapter 8.." The art of seeing the forest AND the trees". BTW, Systems thinking is either a blessing or a curse, as I think you would recognize. I pray we are right.
"Systems thinking finds it's greatest benefits in helping us distinguish high-from low-leverage changes in highly complex situations. In effect, the art of systems thinking lies in seeing throughcomplexity to the underlying structures generating change. Systems thinking does not mean ignoring complexity. Rather, it means organizing complexity into a coherent story that illuminates the causes of problems and how they can be remedied in enduring ways."
I claim Dr.M. sees Homeostasis as a system level CNS solution while it seems the rest of BP has not seen that and now is basically really screwed. BP has massively invested in indication specifics which has limited their view of the forest...when they step back they just see a lot of trees. They pick their favorite tree and have missed the forest. Dr. M. (and yourself perhaps) sees both the forest and the trees.
Bear, coming from you that means a lot. thx.
I have been lucky enough to study with Dr. Peter Senge (MIT chair systems dynamics). In his book, "the fifth discipline:, he describes how change is managed, etc. The guy is brilliant, like many here IMO.
Is Dr. M. in the process of defining CNS breakthrough? Consider that AVXL is in the process of presenting evidence of treatment for multiple CNS diseases which have till now defied effective treatment. Many here are qualified to discuss that (and have). Just thinking about establishing a broader context for all this clinical w/ Pre work, trials discussion. At what point does it get recognized as a sequence of self connecting dots in a learning process? Who will declare .."hey, these are not anecdotes"?
As said before..."an anecdote here, an anecdote there, after a while they add up."...
TT, thanks for this. I expect your instincts to "Follow the Money" (my words) is correct when establishing process links. BR
Suggests TEVA might be the partner answer:
From session planner abstract:
If this is a fact then it explains a lot of what we have seen. Considering what the worlds population has been going through w/CNS diseases and AD in particular I would have expected a lot more Dr. Lewis "profiles in Courage".
The best proof we have after years of investment/FDA trials and patient suffering is we can say with confidence that the Plaque root cause for AD thesis is wrong. I am amazed that w/99.6% failure anyone would even bring it up. But, big money, big egos, and BP prevail. They run the conferences, decide what will be discussed, own the clinics, drive the politics, etc...and they are ALL WRONG.
This bar is probably a lot higher than any scientific bar fro AVXL.
Thanks...this may splain the BIIB non PR so far...they have until 27th.
I thought 27th.
We read that WSU ABSTRACT will be released on Sunday 10/15. Any thoughts on what to expect? How ABSTRACT is ABSTRACT going to be? Will it help connect any dots? Agree w/others on confused why MS gone missing from the schedule and the whole BIIB MA thing.