Anavex Life Sciences Corp (AVXL)

[nidan7500]

It appears Dr. Perry has been swimming upstream against the popular flow for a long time. He is exactly the kind of guy we need to advocate strong P2/3 analysis. It all fits.

"If I had to make one guess at this point, I'd say Alzheimer's disease is a metabolic disease."

The amyloid cascade hypothesis is a very simplistic view that was useful to consolidate many observations under testable hypotheses. Failure of those tests has now put the hypothesis in question. Unfortunately the cascade hypothesis is fundamentally an abiological concept. It goes against evolutionary selection; it does so by proposing a well-adjusted organism would produce a response that has but a detrimental effect. For a response to develop in the body it must have some adaptive value.