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Thoughts tonight are that Britian has had a plan to capitilize finiancially on selling dcvax to paying customers around the world. Hence we had the approvoal of Advent to manufacture and ship anywhere. The model of paying customers has been fine tuned for last couple years...Probably 50 grand usd upfront which includes 2 shots the 25 gs a shot after that..and cost decreasing after 6 shots.
Compasionate use is currently approved for any indication so NWBO can collect data on all cancer indications while getting paid.
Obviously this scenario only works with approvoal of flashworks device which I believe will happen quicker than expected.
My reasoning for this scenario is never underestimate the British... who were the world leaders before second world war. They know how to make money and previous colonies still respect them and the rich in those colonies will gladly pay for a new cancer treatment without side effects.
My
I can buy hiltonol right now from a compounding pharmacy. Go online and check it out.
Once its approved those pharmacies wont be advertizing it anymore because they will be sued.
Iam hoping that specials program has been including polyicl (hiltonol) in its treatments since 2017... and the results of that real world data are going to be announced a week after the nature article.
Mhra approvoal, nature article about polyicl and dcvax 60% alive and then numbers alive from specials program treated at the optimal timing with and without chemo.
Seems to me like anyone accepted into the specials program has been sworn to secrecy as no one talks about it. I bet when they are allowed to speak they will be very vocal.
So the conversation wont be about comparing 5% survival to 13% survival...It will be about comparing 5% survival to 60% survival in the most lethal cancer.
Allow the big investor in first with a purchase of 100 million shares at 3.50 to set a base and get uplisted then let the news flow.
Who in there right mind would not want this treatment for their child? Personaly I would pay for dcvax treatment in england and I would buy polyicl from a compounding pharmacy...that would be if its not already being administered as a treatment which I bet it is. You know kind of like the trial how it let all patients receive dcvax if they progressed...Every patient now is advised to ask their doctor for polyicl.Which is available.
So all you relentless bashers of dcvax tell me what you would do if your daughter was diagnosed with glioblastoma...
How would you proceed.....please enlighten us
So India connection now… we know Britain and India are connected through history and commerce.
India was first to approve a dendritic cell therapy (obviously inferior to dcvax but nonetheless somewhat effective).
Some poster stated that lucephries collection was already occurring in certain areas.
So if they include India in submission with Canada and the others it would be a big boost.
Start with approval of importing the treatment with the plan to have manufacturing in India.
India has a huge drug manufacturing operation and they ship around the world so don’t underestimate them.
So a pragmatic guess as to when MHRA will approve would be early approvoal...anytime after march 22 meeting.
My thinking on this is that Britian is proud of this new advanced therapy. A part of the story that will be told for the next 20 years is how Britian expidited approvoal of dcvax and moved along approvoal for other indications also. You only get one chance to approve early...and because its been 3 months thats also enough time to properly review.
British know its going down in the history books as one of the greatest breakthrough in cancer treatments of modern times. British have liscened Advent for manufacturing and export of dcvax around the world for tumors....Not just gbm. Obviously there keeping track of efficacy in other cancers. It would be wonderful if Nwbo has been including polyicl in all treatments for the last year and a half.
I believe we do know that every patient that that is treated in the compasionate/specials is followed up and entered into a data base that is now finally accepted for evidence for regulatory approvoal.
Ohh I would love to see approvoal in Britian for GBM along with the announcement that anyone outside the country can pay 200 thousand pounds for treatment for any indication.
And to follow up in 2 months announce flaskworks approvoal and drop the price of treatment to 150 thou pounds.
If negotiations are stalledand they ask my advice I suggest its time for NWBO to announce a partnership deal with one of the 170 companies that have approved PD-1 treatments.
Choose a company that has shown improvements beyond the leading Pd1 (keytruda) add polyicl, get 10 or 20 million upfront with the deal backloaded. and do a deal for a smaller indication like pancreatic cancer.
This might be catalyst needed to move the negotiations along.
Or on the other hand the long awaited sweetheart deal is already negotiated.
Heres something to think about.
We have a huge binary event that can happen any time from now to May 30th. Thing is the board shorts make no big deal of this binary event. Previously over the last 20 years when I got ripped off by the cartel they would pump the stock up to high prices before decisions because they knew the fda outcome I lost a shitload of money and did allot of praying.
Anyway looks like the plan is to play down this approvoal. Shorts are setting expectations low anywhere between 1.50 and 3 bucks.
I think they are hoping cash starved long term shareholders sell 10 to 15% of holding down there in the volatility they create.
Good luck visionaries!
Oncivor article pre written so people can research Oncivor after partnership news realease and or nature article. Thanks for link norisk
Said a prayer for you Smokey, a cancer diagnosis for self or a loved one is what brought many investors here. Its sad that real immune therapy treatment is still not available.
On another note you dont post often but your sincerity has always shone through.
All the best on your journey.
Global CDMO Calalent was just purchased for a stagering 16.5 billion usd by Novo holdings (whoever they are)
Previous to this deal was fisher scscientific buying Brammer bio for 1.7 billion
Cdmo for cell and gene therapy production is on fire. As stated the goal is to cure current bottlenecks constraining production of cell therapies.
This is from Bioimformant, a cell therapy information portal. Look at the dollars being poured into this unexciting treatment.... Anyway on the other hand theres lots of potential partners coming up with better efficacy and less side effects that would love to partner with dcvax.
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Heres my prediction of what can happen any day now. Based on the common assumption that some hundreds of millions of shares need to be purchased. Our enemies like to front run news so they can operate in a vacuum. This gives them more control of the narrative.
I predict there will be big run up before news. The goal is to accumulate as many shares as they can from 1 to 5 bucks. People have asked why shorts are not covering at these current prices and the answer is simple. Obviously there's no shares available around this price. They need 100s of millions of shares and they will run the stock price up and accumulate then run it really high for a couple of minutes selling to each other painting the tape and then drop back... So next time it hits that price your selling.
The strategy is to operate from a manipulated low share price and then claim that your greedy by not taking a 5 or 10 banger... and all while the price of the stock keeps dropping from this manipulated high stock price. Stock waterboarding... up fast down slow...
And this happens again and again at a higher price while accumulation continues.
This prediction only concerns the shorts covering . If an investor that was trying to negotiate a buy in with nwbo and could not reach agreement and decided to buy on open market that could create competition for shares.
So I am predicting a bull raid out of nowhere to happen anytime before March 07.... because at some point some rich dudes are going to see what we saw 5 years ago. And jump on that pr bandwagon.
Thanks beachhyena, so the kings being treated in Britian by a new progessive therapy.
Fact is DCVax is approved for use by payment for all solid tumors not just gbm.
Fact 2 is it was stated that advent is the most advanced cell manufacturing plant in Britian. So it would make sense that this is where his treatment comes from.
Fact 3 is if there was a competing new therapy, or drug even close to dcvax the miscreants on this board would have been raving about this new drug and we would be aware of it...
So my thoughts are 90% chance King is using dcvax.
Probably not ready to announce that right now as this was a new development that wasnt in the timeline.
But perhaps in 6 months and after dcvax has been approved for gbm the king will say he feels the new treatment is working. And for the cost of 250 grand people all over the world can pay for a new cancer treatment that actually cures without side effects
Flipper along those lines of wondering about how Britian would benefit by being known as the quickest yet thourogh regulatory bodies now approving new therapies...
I am hoping that they offer full price medical treatment to any country they have relations with around the world. Britian is still hugely respected.
Anyway it would be so amazing for a political party to announce that we can afford to offer this new treatment to our British citizens and its being subsidized because the British govt is making money selling it full price to paying foriegners.
I know Advent now draws proccesses and stores your adipose stem cells for 20 grand.
Here is what will happen regarding off label use of dcvax. As soon as its approved for gbm it will be requested by patients for all types of cancers immediatley. The treatment will be an immediate success only limited by manufacturing capacity.
Smitty saying doctors will be hesitant to prescibe over threat of legalities is laughable.
You know why some doctors get sued for prescibing off label? Its because they prescribe additional expensive chemo posions on top of the chemo they are already taking.
Has anyone else ever seen people on 10 drugs or more.
So if a patient asks for a new treatment thats totally different than a doctor suggesting that a patient may benefit from an addition of another drug with additional side effects.
Excellent post Biosect regarding a realistic market cap going forward. Love the added colour!
Why no deals announced yet we all ask ourselves.
And a scenario thats been proposed before is a deal has been agreed to with a big pharma and that partner is controlling the timing of the deal announcement.
This would explain why nwbo has not taken a big name equity partner that could promote nwbo.
Its because they wont take an equity partner now as the deal they have worked out is to lucrative and would fall apart with another investor.
So big money that wants to get in would have to buy on open market, pushing up stock price and loose all credibility in the big finiance world.
So my theory is Linda P wont sell stock to big investors here. The big money wont front run this and buy 100 million shares here and move stock to 2.50 because they will be blackballed by the rest of the investment community.
I think the guys in the know wait there turn to invest. Its the unwritten code and Linda powers is not at all nieve to it.
So at the end of the day shes going for the big money....And thats why she can wait here at 60 cents for last 2 years..
She has way more patience than me! Good luck visionaries
All of a sudden lots of talk about a buyout and the price it would be.
It would definitley make sense for the acquirers to make there move now on the eve of nwbo success.
Perhaps offer 15 bucks a share now before MHRA approvoal, before the judge rules on mtd, before revealing how nwbo were planning on obtaining approvoal in USA, Canada and Europe
My worry is that because we have inflated share count from naked shorting a fake quorom could be achieved. Thus allowing the miscreants off the hook.
Anyway it would help me make sense of the share price being kept down here at 60 cents where they have covered 0 shares and actually shorted more here.
These wall street swinging dicks are going to take the loss at 15 bucks a share and probably declare themselves long once merck or whoever buys in.
But regardless weather the deal gets done at 15 bucks all the naked shorts will be covered at that price or below. 600 Million real shares will come out around that price... especially when volatility moves it between 8 and 18 bucks
Chances of polyicl addition being included in mhra approvoal... Iam giving it a 50% chance and perhaps the wording that it be prescribed by a doctor.
The basis of my assumption is the positive clinical trial with polyicl and dcvax And then the addition of real world evidence from the paying customers in Britian that received both polyicl and dcvax.
The evidence used is biomarkers showing increased response to treaatment. Thus not having to wait for long term survival data.
These last 2 years of waiting must have been for something big and unexpected imo
Dstock I think I might speak for some investors and want to thank you for your amazing due dillegence in connecting the dots. And everything you find you often supply the links.
From potential partnerships, company hiring , cancer moonshoot and other info you have offered were very thankful.
I want to offer a weak explenation why you dont get a ton of feedback sometimes..Most investors like myself invested in 2015 or therabouts... and been thinking our payday was at most a year away from that time. So we have tempered expectations. I believe your a fairly new investor so I can see your excitement.
Dont get me wrong us long termers believe but now many of us are ready to wait for actual revenues ...which wall st dosent deny.
So even if you dont get lots of replys your much appreciated. Thanks
Ex your excactly correct that the way shorts make money is by unloading shares on retail at a high price and then driving that company into bankruptcy. They came close to bankrupting nwbo but did not succeed
Now your job is to keep price low so your short bosses can cover their wrong bet.
Is there another explenation?
Great post full of common sense. To reiterate... NWBO started combination trials 10 and 4 years ago even though they were broke and it was unproven technology. What biotech company looks that far ahead??
Talk about the long game... Iam sure Linda P never thought it would take this long but imagine starting the work 12 years ago to set up the 10 year polyicl trial before she knew the true efficacy of dcvax.
Where is the long term data from any other potential cancer treatment?We have20 Year data from Dcvax... now 10 yr data from a combination trial with 60 people with unbelievable efficacy and no side effects.
And most importantly I believe were past the point of this technology being buried...
Iam ordering my certificates next week.
This press release was for the die hard long suffering investors to have something to talk about at Christmas dinner. Sets the stage for whats to come.
Biotech starts anew in January with the various confrences and Asco submissions.. Sell in May and go away is the perenial line.
So starting Jan 02 anything can be announced. New trials,partnerships, who gave us 3 million for placeholder, Manufacturing advancements,partnerships patent approvoals.
The upcoming Preliminary readout of 10 yr trial that ends Jan 2024 with PolyIcl
Biden needs to talk about Cancer moonshoot. We know as investors of nwbo that we are not aware of a better cancer treatment anywhere close to approvoal.We know this because we have heard about every rat study and phase 1 cancer trial from Jondeuk and Learningcurve. Yet we have heard nothing close to dcvax potential with no side effects...And then we have addition of polyicl that may be descibed in the upcoming Nature article.
Exciting times my friends. Nice to have something to look forward too.
While we look forward to being an investor of the company with the possible cure for cancer and we have the chance of getting rich... The others on here 24/7 bashing can only rejoice if this company goes bankrupt and or dcvax fails to get approved.
Think about that logic
So we know nothing compares with dcvax. And especially a drug that completed phase 3 and has now submitted for MHRA approvoal
Big name investor backer coming onboard with a billion dollars because he sees what we see and it would make him look good plus probably 10x his investment by bringing notierity to the stock.
Thanks dstock, I think many investors missed this important study. The natural immune response to brain cancer without dcvax recognizes and attacks 20 peptides it sees as foreign. But if DCVax is introduced to the tumor then the imunne system recognizes up to 1200 foriegn peptides that can be attacked by the T cells.
This proactive proof of showing how dcvax works blocks the arguments of the forces working against approvoal.
You can see the shorts aree running the ihub board because the 2 top peged posts are Kypee and doctor High.. 2 flakey bashers.
Kinda like when the librarian pegged the made up AF article.
Unfortunatley I think the plan of the miscreants is to overun this forum with spam and bull and drowned out real conversation.
This post is important drugruner, your sayng that dcvax is going to come out on the market priced lower than keytruda or Car T yet will have better outcomes and less side effects...making it ultimatley cheaper to the health system.
Currently Nwbo hands are tied because they cant promote or talk about the drug before approvoal.
NWBO big pharma partner has most likely been offering larger dollars to take the time to hit milestones. Because we all know that big pharma is in no rush to announce this new breakthrough
I believe the British health care system wants to take leadership role in the world providing new cutting edge therapies. And beyond that selling the treatment to people all over the world that trust the British medical regulatory system and will pay for it. Thus we had the liscence granted for Advent to export their cell treatment around the world.
Britian will pay for gliobastoma patients for citizens and sell treatment to any other people that can afford it.
Another inciteful post Ilovetech.. LindaP has been going against the big boys and playing the long.. no longest game.
We can see from our due dilegence that theres not another cancer therapy that comes close to what we have here.
I think we had some big investors that approached nwbo wishing to come onboard that were previously outside healthcare.
Once big pharma got wind of it they ponied up finally and And of course they slowed down the whole process.
And my point is that for NWBO management to keep quiet for the last 3 years and not promote themseves... is because someone(merck) has been holding the largest carrot over th their heads in order to control the timing of this new paridigm. And potentially timing it with cancer moonshoot program..
Anyone heard of a better breakthrough therapy than DCVax?.. Didnt think so.
Good luck fellow visionaries and dreamers
Well put Jimmy1
I think any big news of acceptance of submission, new trials, partnership deals,manufacturing details are not going to be announced until the new year.
Wall street is on vacation mode starting next monday the 18th so not the time to release news.
I do think NWBO will announce submission to MHRA in December but it will be low key.
Fireworks in biotech starts first week of January....And thats when I think our train leaves the station.
This is what has stalled new therapies from Meso, Nwbo and others for an extra 10 years.
The delays are done now.
Japanese take a long time to finalize deals. They wont do busines with people they dont trust. Relationships are built over time. So a deal buying old technology chemotherapies done at a high price could actually mean allot more.
Heres a scenario... Merck says I will pay you big bucks for these chemo poisions and you pretent to sell us the new technology cheap,
I think DcVax and PolyIcl can be priced at a cost of 300,000 Keytruda currently costs 300 thou. To add keytruda to soc it better increase survival 20% from poly and DcVax and Merck will have to drop price of keytruda to 150 grand in this combination scenario
So it makes sense that Mercks goal is to buy NWBO.
Dcvax is superior to keytruda in many ways.
You know us longs should not make excuces for this delay. This is the first time in years where the company gave an actual timeline and they failed to meet it. My newly invested son (3 years ago)said they should have just kept their mouth shut and hold off announcement until submission.
So that being said we do not know if the submission is taking longer because we are applying for tissue agnostic approvoal for some indications.
We do not know if we are going for approvoals that are based on identifying biomarkers that would identify patients likely to have positive outcomes
We do not know if the submission was delayed in order to include the flaskworks device.
We do not know if submission was delayed to incude polyicl into the approved formulation of DCVax
We dont know if big pharma partner has been applying pressure to slowwalk the submittal.
We do not know if NWBO is submitting simountaneously to the 4 regulatory boards under Orbitz .
Lots of stuff we do not know.
Kabunushi, when valuing this company try to price in the years of manipulation that has kept stock price low.
You stated it could take 2 years to be fair valued...Thats ridiculous.
Our stock story is the biggest powder keg on wall street. Cure for 60% of cancers with no side effects. Compared to huge valuations for new amazing ways to deliver fast food.
This is the stock market. Know that this story stock can get traction and quickly pass any valuations that have been talked about here.
Long term investors believe this is the real deal. And because we are inteligent we know that were not the smartest guys in the room. If we see the potential here smart money does too.
Here is a solid fact. The shorts on this board have made us aware of every upcoming new drug that may possibly have a chance of curing cancer. Any new drug in phase 1 is paraded out on this board to let us believe that our technology can easily be stepped over. So what we can deduce from the shorts information that they provided us with is there is no new exciting cancer therapy treatments on the horizon.
To be clear what I am saying if any big pharma had an exciting drug even in phase 1 we would know about it.
Shorting down here at this low price sets shorts up for accumulating large shares at diferent price points on way up. People take a little off the table when they get 2,4 6 banger
Second shorting down here helps imensly with partnership finiancing and buyout negotiations.
Third they think that you as a retail investor are dumb money.... And being dumb you should take the new shiny coin and not be greedy
The shorts are a consortium of big pharma $ that conspire together to keep potential competitors down. Theyre tactics have worked by bankrupting many companies and even with nwbo there methods will most likely pay off.
By keeping our market cap at 10& of true value big pharma will make out just fine. Negotiating partnerships or buyouts from this low valuation is just the second best scenario they planed for.
The billion naked shares will be covered from 10 to 30 bucks which is still cheap when you compare it to what big pharma pays for revenue producing biotechs.
Moral of the story is integrity of management has a huge bearing on weather your company will succeed.
Thankyou nwbo team!
A smart billionaire may want to try to front run this investment right now and capitalize on the good will that backing a new cancer treatment paridigm would bestow on them. Or perhaps it might make them feel good to know they made a meaningful contribution to the alleviation of human suffering.
There is not a chance in hell that other big money players dont see the potential that we see.
But what I believe ithat has been holding many of them back is they know they would be going against one of the strongest powers in America. The big pharma drug cartel.... Who probably account for 25% of add revenue for big media, and are the major contributor to the 2 political parties.
That being said some up and coming guy with balls should announce hes taken a position on the open market and plans on buying lots more stock.
With the possible 18 upcoming catalysts that baxter mentioned I would think now would be a perfect time to front run the news and buy up 20,30, 50 or 100 million shares
I believe there has been some short covering happenning. There covering the naked shorts while making it look like they are shorting more by legally borrowing some shares... Deceptionis the name of their game
Yes a month after Mesoblast second fda denial.
Finnaly, ..all guidelines from fda seemed to have been delayed a year or two especially when it relates to cell therapy treatments
I noticed this came out after second denial of mesoblast mesenchymal cell therapy for graft versus host disease for kids under 12
This trial had 60% living with no side effects compared to approved treatment with 20 % survival. Disgusting regulatory decision that I am sure suprised many working for CBER in FDA.
Mesenchymal cells targeting inflamation have proven there efficacy ... heart, back pain, ibd, arthritis without side effects... we wait