This link from 2014 indicates nx-1207 failed to meet primary endpoints, THEN through '15, and now in '16 it's had significant success in phase 3 trials.

https://globenewswire.com/news-release/2014/11/02/678844/10105809/en/Nymox-NX-1207-BPH-Pivotal-Phase-3-U-S-Studies-NX02-0017-and-NX02-0018-Fail-to-Meet-Primary-Efficacy-Endpoints.html

I'd welcome enlightenment -- what failed before that is now succeeding?

I'm new here.... fresh out of avxl. I've only started dd on imnp and it seems it's gone down perpetually for 2 years.... with large insider buying all the way. Are they averaging down? Some bought at 1.50. welcome any enlightenment.

JMO, i think you've put your finger on the throat of the poster.
I'm dissapointed that Missling felt this middling data had to be held past 12 weeks and messaged into a statement of "stability" after a cheesy switch of promising title. ....And McFarlane now seems inappropriate in raising hopes.
I usually like small studies, because a noticable effect is a big deal, not having to be teased out of hundreds.
IF 2-73 doesn't validate targeting sigma-1 and muscarinic receptors, then 3-71 will never get to bat. I really hope i'm wrong.

FWIW -- If you have a problem smelling rose, leather, orange, fish, and pepperment.... it could be an early symptom of cns disease.
----------------------------------------------------
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107541
Olfactory Dysfunction Predicts 5-Year Mortality in Older Adults
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http://www.ncbi.nlm.nih.gov/pubmed?cmd=Search&doptcmdl=Citation&defaultField=Title%20Word&term=Wilson%5Bauthor%5D%20AND%20Olfactory%20impairment%20in%20presymptomatic%20Alzheimer%27s%20disease
Olfactory impairment in presymptomatic Alzheimer's disease.

hfb -- you've put it very well. My only fear and hesitation is that the body accomodates the drug and there is a plateau or, forbid, a "flowers for algernon" decline. I share your hope....

Same thing as last year at CTAD in barcelona. The conference didn't allow spoiler titles... and they had to not hint at results. Don't know if this change is sloppiness or dropping hints till told not to, or walking back results. Do they have time to change it on the posterboard?! New stuff is supposedly mandatory.

i took about 1/6 off the table.... I was overbought. Even Sunday's poster must have new stuff, and mentions cognitive improvement observed in mmse. Hopefully the greater fear, less hype this time around portends good things.

good post! I was one of the ptsd victims. OMG, down 25% every day for 4 or 5 days, or so it felt. Loving the green trend, but really fearing a smack down. Should I hold thru news? Are hopes a little too high? ....

"New Exploratory Alzheimer’s Drug Anavex 2-73: Dose Dependent Clinical Cognitive Improvement Observed in Mini Mental State Examination "

....a great heading for the presentation..... and i could have sworn that at CTAD in barcelona last year they couldn't have such a headline. It couldn't give results in title. It had to say only "assessment of safety and cognitive performance..."

Maybe this year the rules have changed...

fwiw .... interesting biology.

---------------------------------------------

http://www.ncbi.nlm.nih.gov/pubmed/26560551

Biochemical Pharmacology of the Sigma-1 Receptor.

"...Based on its biochemical features and mechanisms of chaperone action the possibility that the S1R is a member of the small heat shock protein family is discussed."

-----------------------------------

"Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock,[1] but are now known to also be expressed during other stresses including exposure to cold,[2] UV light,[3] and during wound healing or tissue remodeling.[4] Many members of this group perform chaperone function by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.[5] This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF).[6] HSPs are found in virtually all living organisms, from bacteria to humans."
-----------------------------------

"....they cant withhold material bad results especially with the SEC sitting on their a$$..."
I'm no expert, and welcome correction. I used to think the same, that materially negative results had to be divulged in a timely manner.... but I searched and could find no rules or laws that require that. I hope and expect the results will be good.... but my darkest fear is that the results will be middling and perhaps show a tapering off.... and the data is taking time to be massaged.
But that's too negative. Pk/Pd takes time and there's a hammer blow coming.

george -- this is fun!
it's a $1.2 billion dollar industry. Researchers gotta get paid, companies gotta hype and sell the pills.
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Fish oil pills: A $1.2 billion industry built, so far, on empty promises

https://www.washingtonpost.com/business/economy/claims-that-fish-oil-boosts-health-linger-despite-science-saying-the-opposite/2015/07/08/db7567d2-1848-11e5-bd7f-4611a60dd8e5_story.html

george -- getting 10,000 times what you need an itty-bitty bit of is actually not natural or productive, or protective.

The following link indicates fish oil substantially increases lipid peroxidation and MDA, malondialdehyde, which is a serious carcinogen.

I have a dark glass bottle of the good stuff in my fridge, and it has remained unopened since I read Masterjohn years ago.

http://www.westonaprice.org/know-your-fats/precious-yet-perilous/

you're beered!

"I think in the future genetic evaluation and dietary paradigms will play a big part in the longevity of the species. It's all there in nature. We just come around to it in a pseudo-scientific molecular chemistry-based way. We'll catch up with mother nature around the time we really need the knowledge to protect our survival....."

Excellent paragraph -- preachin' to the choir! This is why 2-73 (and 3-71) feel like the edge of space. BUT will we only save ourselves in time to elect Trump!?

http://www.nature.com/nrn/journal/v12/n5/box/nrn3012_BX3.html

"Lipid peroxidation products (LPPs) have been found in brain, cerebrospinal fluid and plasma from patients with Alzheimer's disease (AD)147. Primary substrates for lipid peroxidation are PUFAs and include ?-6 fatty acids (for example, linoleic acid and arachidonic acid) as well as ?-3 fatty acids (for example, docosahexaenoic acid). "
---------------------------

http://www.ncbi.nlm.nih.gov/pubmed/12679837

"...Here, we review possible mechanisms whereby lipoprotein trafficking and lipid peroxidation converge to contribute to neurodegeneration in AD brain."
-------------------------------------

ipman -- lipid peroxidation is a very inflammatory process -- and not all lipids are equal. Your last link is about Alpha Linolenic Acid (ALA), which is NOT linoleic acid.

2-73 claims to mitigate inflammation from ROS -- free radicals....so.....I dunno -- maybe it helps with some of the lipid peroxidation products (LPPs) -- but losing the PUFA's, imo, is a very good idea.

yes george, lipids are important.... we couldn't be here discussing it if we didn't evolve with lipids, BUT lipid peroxidation is an inflammatory process and not all lipids have the same effect in the body.
The person who foolishly consumes lots of fish oil and veggie oil to fight alzheimer's will be inviting other maladies. MAYBE our growing problem with alzheimer's is CAUSED by our dietary excess of linoleic acid.

Soybean oil is nothing we evolved with.... and now the american diet is 7% soybean oil.... and soybean oil is 50% linoleic acid. We are fat and saturated with linoleic acid... so.... why so much AD!?

Best for brain health is ketones.

hunters please use caution when hunting pedestrians using walk trails.

Let's eat grandma.

Panda eats, shoots and leaves.

Punctuation!

beware the pufa's.....

On the subject of free fatty acids -- the animal fats -- palmitic, stearic, and oleic are neutral in their inflammatory effect, but the veggie, omega-6 fatty acids -- linoleic and arachidonic are inflammatory and grow cancer very well.

Our adipocytes are increasingly full of linoleic acid.

old hippies don't get AD....

http://www.ghalabs.com/2015/10/23/hippies-dont-get-alzheimers/

i'm surprised at the blowback you're getting.
I nervously, anxiously agree. The folks who know, want to see numbers on Saturday, or Monday will be a real bummer.

Cancer folks have "scanxiety" Times like this bring on biostockxiety.

This is definitely fine .... but my impression is 12-wk is due, if not overdue. Greece is the right place, props to Vamvakides. IF there's no 12-wk data, it will be a niggling concern. I hope Dr. M is holding some nice cards close.

my bad.... i just realized previous post referred to apoptosis of effector t-cells prior to reinjection. I was refering to apoptosis of cancer cells.

i agree. It bothers me a little that the fever reaction is so insignificant..... makes me think adjuvents will be necessary. And apoptosis doesn't bring the boys to the yard.... something that lyses may be necessary.

is this all there is?! i almost posted yesterday about the rising pitch of euphoria....and now we get parcing, prevarication, a tease?....again...... there is the implication of a suggestion of an indication of possible, potential systemic action..... oh well.....they don't call it an abstract for nothing.....

Seyfried sees a downside to immunotherapy.....he sees macrophages causing mets.
http://www.evolutionary-health.com/articles/immunotherapy-and-metastatic-cancer-tread-carefully

where's pyrr these days? He had a nice series of articles on the fact that dcvax, by itself, likely won't be enough. The tumor microenvironment will teach us to curb our enthusiam.

jtorence -- others here can give greater insight, but I imagine, yes indeed a biopsy can assess exactly what you state. Some time ago there was science I can't locate now indicating a novel blood test for immune activity against tumors.

i'd say evolution is proof enough for me...
Do you have some pcrm docs you want to bring to support veganism?

off-topic diet stuff.
afford -- it has a lot to do with evolution and eye placement.
If your eyes are on the front of your face as you look at your monitor..... it means you come from a long line of predators who had to chase down their food.
otoh, if your eyes are more towards the sides of your face..... like a cow or horse, or rabbit....then you come from a long line of prey animals whose food did not run away.... and allowed them to graze all day, as they needed to, because of the lack of nutrient density.
Species appropriate diet would indicate veganism is wrong for us.... and in fact, heart disease only started, when we got agricultural and all heart-healthy whole-grainy.

--------------------------------------------

Ancient Egyptian Princess Now Known to Be First Person in Human History With Diagnosed Coronary Artery Disease

ScienceDaily (May 17, 2011) — The Egyptian princess Ahmose-Meryet-Amon, who lived in Thebes (Luxor) between 1580 and 1550 BC and who is now known to be first person in human history with diagnosed coronary artery disease, lived on a diet rich in vegetables, fruit and a limited amount of meat from domesticated (but not fattened) animals. Wheat and barley were grown along the banks of the Nile, making bread and beer the dietary staples of this period of ancient Egypt. Tobacco and trans-fats were unknown, and lifestyle was likely to have been active.

http://www.sciencedaily.com/releases/2011/05/110517121824.htm

-------------------------------

afford -- I can go on and on and inundate with off-topic links. Bad feed-lot, grain-fed meat is indefensible and unhealthy. But that's not what our bodies evolved on, anymore than daily neolithic produce.
But now.... political correctness, perceived morality, perceived environmentalism, and corporate agendas make the quest for healthy lifestyle far from simple and obvious.

It's so sad....the hurdles to progress.....and yet it's amazing we can actually do leukapheresis and get goldilocks DC cells.
I've had cancer-lite and dbl-bypass and have studied nutrition. I've learned "vegan and green smoothies" contribute to the cause and not the cure for heart disease. The lie of the lipid hypothesis is too entrenched.... and......very profitable. And once disease becomes clinically detectable and symptomatic.... diet won't cut it.
Illuminating of patient psychology, is the fact that we evolved....not to seek truth..... but, to win -- win arguments, win influence over others.
And, facts don't change our minds. Our confirmation bias is perfectly capable of looking past discordant info.
I'd hate to recommend a change of treatment and have it go wrong. I think it's great service to put the note out there to a patient or their family..... and let it be. But so many are low-wattage fighters and find comfort in convention and god.

From my limited reading, immunotherapy is a different animal and may need different measures of efficacy. Shrinking tumors do NOT necessarily correlate with pfs or os.

http://www.nature.com/nrc/journal/v12/n4/full/nrc3258.html

"Immune and clinical efficacy. Most Phase I and II studies have stumbled on two crucial issues: how to assess the clinical efficacy of cancer immunotherapy; and how to define the correlates (biomarkers) of clinical efficacy127. Initially, the Response Evaluation Criteria In Solid Tumours (RECIST) had been designed to assess chemotherapy-based trials and were considered to be crucial for assessing clinical efficacy in vaccine and immunomodulation trials127, 128. However, this has recently been challenged. A randomized Phase III clinical trial testing anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA4) in patients with stage IV melanoma, showed a twofold improved overall survival in patients who received the drug129. No early tumour shrinkage was observed in treated patients, which reflects the slow build-up of anti-tumour immunity. In fact, in the early phase of treatment, tumours might increase in size and new lesions might appear; these are findings that normally call for removing the patients from the trial. However, the enlarged tumour size might instead reflect the inflammatory process that is associated with active immune responses and lymphocyte infiltration."

i'm very sorry Mr. Demeger has passed. I might be mistaken but I thought progression allowed crossover and I'd be inclined to think, at some point, he got the vaccine....

this is slightly off-topic. I appreciate the insights and efforts and enthusiam that accompany this welcome WP article. ....BUT.....IMO...... this weekend there was an excellent NPR broadcast of secret tapes of federal reserve regulators meeting with Goldman Sachs execs over dubious financial dealings. The culture of fear that pervades the regulatory bodies will not allow real oversight....and spreading the word about nwbo will have little effect until dendritic cells do their job better than anyone else's ....and, only then, we're on the news and the games are over.

i saw this today first time myself......and i'm in champaign, illinois, and he's my anchorman. I had no idea, but not a terribly regular watcher. His cancer has returned so I thought he'd still be a candidate for direct. I posted in comments on two of the news sites and on his facebook page....which is inundated with well-wishers pushing baking soda, cannabis, and everything else. ....this can't happen fast enough.....

the new wave of cancer therapy!!!! .....jmo, i think it's a money trail.....a boy's club, fearing to tread where real innovation lies....and profits not so controllable.

irAEs -- immune related adverse events.

"....However, targeted immunotherapy has come with a price; altered immunoregulation provoking immune dysfunction has opened the door to opportunistic autoimmune disorders."

This current rage of checkpoint inhibitors can inhibit immune checkpoints that the body needs to keep from attacking itself. Our track is signficantly more natural -- but we're not in the boy's club.

flipper -- appreciate your efforts -- thank you for that patent post.
On another board, in another discussion, a cancer fighter is using Newcastle Disease Virus (NDV) as an oncolytic virus to infect cancer cells, then priming the dc's with ndv antigens. At first I thought it was too indirect, a surrogate for tumor antigens......but NDV lyses cancer cells....so dc's would get tumor lysate in vivo.
DC therapy seems to allow for great creativity in the adjuvent and priming options.

i'm admittedly naive about the pharma machinations but, imo, nwbo is being being grouped with imuc and dndn. This is where Buffet said the little guy can beat the street -- in new tech. There may be strong headwinds against dc therapy.....but its time is coming. When the writing is on the wall for big pharma....could they get very underhanded? nwbo, by my reading, has 9 us patents and they start expiring in '15......

does the german hospital exemption put the same strictures on patients that the trial does, in terms of requiring conventional treatment before vaccine? And...why would german dr's put patients into a trial when the gov't offers HE and reimbusement without the risk of placebo until progression? Does the German HE hurt enrollment? tia

EU trials register for dcvax-L
This link and subsequent discussion didn't survive yahoo.
https://www.clinicaltrialsregister.eu/ctr-search/trial/2011-001977-13/DE
The EU clincial trials register for dcvax-L.
Section E.5.1.1 states an endpoint of 248 events......not 110.
Duration of trial is listed as 4 years.

......opinions? insights?