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That was also my thought that Parkinson's sufferers would be those at greatest risk of death from covid-19.
What stuff? You have brilacidin named in your first sentence then you go on to say stuff.
You hire a former FDA lead neurology statistician due to positive results period.
"I'm excited to welcome Dr. Jin to Anavex at this pivotal time". "Dr. Jin's deep and extensive biostatistics experience within clinical development and regulatory process will be invaluable as we advance key mid- and late-stage programs, to provide clinical and regulatory biostatistics leadership in support of Anavex’s goal to bring transformational medicines to the market."
Is this Basilea Pharmaceutica? The share price has been improving. Thanks for posting, three weeks is not far off.
"A European pharmaceutical company will discuss Brilacidin in their internal licensing meeting in 3 weeks. I know this direct from the company and not from Ipix. We will see how the Ipix stories change into the future".
Yes george h this is how I remember it. The first phase2 ABSSSI trial was at a much higher dosage which caused hypertension issues. Polymedix planned a second trial at a much lower dosage but never had a chance to implement the changes, when CTIX now IPIX picked up Brilacidin Leo and company ran the second trial using Polimedix dosage changes.
I like many take a statin so safety is a big concern but for me the good outweighs the bad.
https://blogs.webmd.com/heart-health/20210121/considering-statins-what-a-cardiologist-wants-you-to-know#:~:text=About%2035%20million%20people%20take%20statins%20in%20the,statin%20have%20more%20preventable%20heart%20attacks%20and%20strokes.
Statins for high cholesterol are among some of the worst for possible side effects but yet something like 25 million people still take them. Few people actually experience the bad ones. Seems all drugs come with some form of risk.
Leo supplies the B. Positive results reported so far in antifungal pre-clinical studies even some testing reportedly being done on animal eyeballs.
History can be a brutal reminder. It's been 8 years so yes all the ABSSSI money is down the drain. Leo progressed with OM sold us on a ABSSSI phase3 that never materialized. Those are tough facts. I'm in for BeaMed and the anti-fungal so hope springs eternal.
It's up to the science community not Leo whether B moves into a government supported clinical study or not.
My basis is in the reported. Leo reported On December 22nd 2014, Cellceutix also reported positive results in the Microbiological Intent-to-Treat (MITT) population. This is an important population that includes patients with baseline cultures positive for common ABSSSI pathogens, such as Staphylococcus aureus, including Methicillin-Resistant Staphylococcus aureus (MRSA). In this population, Clinical Success rates at 48-72 hours were again very high (above 90% across all treatment groups) and again very similar (with overlapping 95% confidence intervals).
The results sure sound like people being cured of their ABSSSI.
So now as frenchbroad asked, where's is the evidence that the majority experience either hypertensive crises or peripheral neuropathy?
Whats never noted is that all patience in the ABSSSI trial went home cured.
No fun going down memory lane, Kevetrin and Prurisol are history gone kaput money lost. No big pharma, small pharma not even CVS bought into it. I'm holding my shares only because I think something will come out of months of Bril testing and the BeaMed investment.
Hoping for a brighter future here.
"The thing that bugs me is that the people think the FDA is protecting them - it isn’t. What the FDA is doing and what the public thinks it’s doing are as different as night and day".
Herbert L. Ley, Jr.
FDA Commissioner 1968-1969
It seems to cause a small few to have melt downs. Go B
Whoa I like this: *We expect Basilea to renew its efforts to in-license novel anti-fungals to ensure the longevity of the franchise and believe that its in-house expertise should be a strong attraction for potential licensors.
"With the focus returning to anti-infectives, Basilea needs to re-populate its development pipeline".
B likely on Basilea's radar that's for sure. Good find.
That alone would make A-273 most favorable. Diarrhea would add to daily living struggles and cause dehydration which is dangerous for children.
Poor things seeing some brutal adverse reactions while taking trofinetide. I remember Dr Missling specifically saying diarrhea wasn't a problem with A-273.
Diarrhea: In a 12-week study and in long-term studies, 85% of patients treated with DAYBUE experienced diarrhea. In those treated with DAYBUE, 49% either had persistent diarrhea or recurrence after resolution despite dose interruptions, reductions, or concomitant antidiarrheal therapy. Diarrhea severity was of mild or moderate severity in 96% of cases. In the 12-week study, antidiarrheal medication was used in 51% of patients treated with DAYBUE.
I vaguely remember seeing that statement.
And former Director of Global Science Initiatives, at the Alzheimer’s Association which is the same organization that called for FDA accelerated approval of Biogen's lecanemab. Could be a bit bias.
https://cmtrf.org/scientific-advisory-board/
No problem. Take care.
I see nothing reported since July 5 2022 where it was reported 9.92% ownership. So they still own above 5%.
So I think the answer to your question is YES medicare would welcome an oral CNS treatment over a intervenous treatment that put's the cost directly on the government to shoulder.
The thing about Aduhelm is that it's an IV not a oral delivered pharmacy drug. IV's require clinical infusion which are expensive and paid under Part B not Part D which is what pharmacy drugs are covered under. Part D pharmaceuticals think (CVS) are covered under a separate plan that participants can buy to help cover their drug costs. Part B covers 80% of costs and the patient pays 20% of costs. So with Aduhelm the full cost is charged to medicare under Part B but with an oral drug the cost is on the patient or a separate Part D insurance plan if they buy one and I think most do at some point.
Medicare is quite complicated. I bought a Medicare Advantage plan which covers meds.
Every post negative then more likely borrowed short positions. Need price to go down to make money. Not my cup of tea.
Leo and co are making headway per the latest pr.
"During the visit, BeaMed founders Moshe Eshkol and Gil Shapira provided updates on recent BeaMed progress, including a demonstration of data integration software, as well as a review of different fiberoptics undergoing rigorous testing in advance of final selection and planned submission to the U.S. FDA for marketing clearance. A tour of an onsite FDA-approved facility where the StingRay System is being manufactured was also conducted.
In other news, the Company wishes to inform shareholders that it was notified by the United States Patent and Trademark Office (USPTO) that US Patent Application 16/991812 – Host Defense Protein (HDP) Mimetics for Prophylaxis And/Or Treatment of Inflammatory Bowel Diseases of the Gastrointestinal Tract – was allowed for issuance as a patent. The claims allowed include Brilacidin treatment of Ulcerative Proctitis/Ulcerative Proctosigmoiditis (UP/UPS) and Ulcerative Colitis.
Additionally, the Company and University of São Paulo (USP), Brazil, have entered into a collaborative research agreement to investigate the broad-spectrum activity and treatment potential of Brilacidin in fungal diseases".
Thanks for posting this SitTight. Good to see more multinational studies.
Don't know but my guess is they were newer compounds with numerical names.
September 9, 2013
Cellceutix Acquires PolyMedix Assets from Bankruptcy Court, Gains Ownership of Two Clinical Stage Drugs, Multiple Compounds, and Equipment Assets
Brilacidin
Beverly, MA — 09/09/13 — Cellceutix Corporation (OTCBB: CTIX) (the “Company”), a clinical stage biopharmaceutical company focused on discovering small molecule drugs to treat unmet medical conditions, including drug-resistant cancers and autoimmune diseases, is pleased to announce that it has acquired substantially all of the assets of the company formerly known as PolyMedix, Inc., and previously traded as PYMX, a clinical stage biotechnology company which developed small-molecule drugs for the treatment of infectious diseases and innate immunity disorders. The acquisition includes the PolyMedix pipeline of nine compounds as well as the substantial equipment assets at PolyMedix’s 25,000-square-foot headquarters and laboratory.
IPIX acquired nine compounds.
http://www.ipharminc.com/press-release/2016/11/16/cellceutix-acquires-polymedix-assets-from-bankruptcy-court-gains-ownership-of-two-clinical-stage-drugs-multiple-compounds-and-equipment-assets
Good to see Alfasigma trial starting second half, potential $24million in play for IPIX.
They got a 5 day reprieve. Hopefully we get something worth the interest.
You chain puller.lol Go Bmed
ANAVEX®2-73 (BLARCAMESINE) PHASE 2B/3 STUDY MET PRIMARY AND KEY SECONDARY ENDPOINTS,
SHOWING STATISTICALLY SIGNIFICANT REDUCTION OF CLINICAL DECLINE IN GLOBAL CLINICAL STUDY OF PATIENTS WITH EARLY ALZHEIMER’S DISEASE
AVXL trial successful. Sound familiar..
SAVA trial is unblinded with no placebo control, this puts them years behind AVXL.
Shorts are hearing the vacuum approaching.
I think we likely get accelerated approval as Leqembi but with much less heartburn. A safe oral Alzheimer's medication that shows efficacy would be hard for FDA to vote against.
Yep me too. I would think insurance even without the payer analysis would cover an oral OM treatment just for the fact of it being an unmet need. I think the biggest hurdle IPIX is facing is that there are very few pharmas in the OM space and they have no money to conduct a phase3. I've all but given up on OM and just hoping for the antiviral or antifungal studies to lasso in a partner.
What we need is a beneficial signed agreement were about running on fumes now.
Was able to pick up a few again this morning:) ++++
Who's to say they will be needing capital any time soon, a shelf placement is more of a contingency. Missling has control of when and if shares will be sold. Since they have 140mm in the bank now I suspect he wouldn't until share price exceeds 50 dollars.