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Anavex right now ... if it was a song
Is this really 7 cents again!? Back from the dead? Or waters rising all boats?
Dipped a toe... $BMBL
This is about to take off !!! IMHO
... just a matter of time/science
$AVXL
Patience And
Perspective
*HUGS* <3
Bargain prices!
Imo
$AVXL
Why the move today?
CB-2 receptors will be paramount for the future of Anavex in my opinion... endocannabinoid system and chromatin. Not to be underestimated.
“The environmental-dependent modulation of gene expression usually occurs at transcriptional, post-transcriptional, and translational levels. In general, the main epigenetic mechanisms involve the chemical modification of DNA and histone tails with consequences on chromatin architecture and accessibility to transcriptional factors and the production of specific regulatory ncRNA [8].
The main chemical modification of DNA is the covalent transfer of the methyl group (-CH3) to cytosine located within cytosine–phosphate–guanine (CpG) islets in the gene promoter region, thus forming 5-methylcytosine (5mC). This modification changes the chromatin structure from an opened (transcriptionally active) to closed (transcriptionally inactive) state [24]. DNA methylation is typically erased during zygote formation to be newly established in the developing embryo in order to address proper embryo development and to drive gene imprinting, the process causing genes to be expressed from a parent of origin-specific manner [25]. Different DNA methyltransferases (DNMTs), the enzymes involved in this epigenetic modification, are classically responsible for de novo and maintaining methylation, but cooperative activity has also been reported and reviewed [26]. Classically, de novo methylation is established by DNMT3A and DNMT3B in participation with DNMT3L, a DNMT devoid of catalytic activity, but capable of assisting de novo methylation, increasing the ability of DNMTs to bind to the methyl group donor, S-adenosyl-L-methionine (SAM). Once established, DNA methylation status is maintained by DNMT1. Conversely, the Ten–eleven translocation methylcytosine dioxygenases (TET1-3) catalyse the oxidation of 5mC to 5-hydroxymethylcytosine (5hmC) [27].”
“Transfer RNAs (tRNAs) produce several fragments involved in repression of translation. Some of them, called 5’- (3’-) tRNA halves (tiRNA, 30–40 nt long), are stress-induced and are produced in humans by the endonuclease angiogenin that cleaves within the anticodon loops of mature tRNAs. Another group (17–26 nt long), usually referred as tRFs, is produced by the processing at the 5’- or 3’-end of mature or precursor tRNAs [35,36].
LncRNAs are bidirectional, antisense, intronic, intergenic, or overlapping transcripts capable of modulating the transcription of neighbouring protein-coding genes with remarkable tissue specificity. They also remodel chromatin and genome architecture or stabilize RNA through the recruitment of chromatin-modifying enzymes or directly acting as cis/trans scaffolding factors [37].
The ES is an almost ubiquitous cell signalling system regulating several processes inside cells that are not yet completely understood. From its discovery in 1990s, it was clear that this system could be modulated by both extrinsic (cannabis and its derivatives) and intrinsic (the endogenous ligands) signals. Subsequent studies pointed out that the ES is much more complex than was thought since it is able to cross-talk with many other transduction cell signalling pathways, therefore regulating key biological processes such as cell proliferation and differentiation, synaptic plasticity, gametogenesis, and fertility. From the data herein reported, it emerges that epigenetic modifications of the ES by means of DNA methylation, histone acetylation/deacetylation at the CNR1, and FAAH genes encoding the CB1 receptor and FAAH hydrolysing enzyme may play a relevant role both in physiological processes regulating (male) fertility and reproduction as well as in disease pathogenesis and progression including cancer.”
“MiRNAs (20–22 nt long) are endogenous small ncRNA classically involved in RNA interference and their exogenous counterparts are siRNAs. In most cases, they bind the 3’ untranslated region of target mRNA inhibiting their translation into protein and inducing their degradation; however in the nucleus miRNAs may target mRNA co-transcriptionally, recruiting chromatin-modifying enzymes and inducing epigenetic regulation via DNA methylation or histone tails modifications [34].”
“They also remodel chromatin and genome architecture or stabilize RNA through the recruitment of chromatin-modifying enzymes or directly acting as cis/trans scaffolding factors [37].
Originally characterized in germ cells, piRNAs (26–31 nt long) target heterochromatic regions through the formation of a PIWI–piRNA complex which usually is associated with the repressive histone/lysine methylation marks, but may also recruit different chromatin-modifying enzymes or facilitate transcription [33].”
“Spermiogenesis is the process leading to the formation of spermatozoa and is characterized by round spermatid elongation, acrosome and tail formation, nuclear shaping, and DNA packaging with transcriptional silencing as a consequence. Chromatin remodelling and DNA packaging are therefore the main nuclear events in spermiogenesis, consisting of a double-step process that requires histone replacement, first by transition proteins (TP2 and TP1) and then by protamines (PRM1 and PRM2), a class of small basic proteins [139]. The cooperation between HATs, HDACs, molecular chaperones, ubiquitination, and DNA repair systems drives the shift from a nucleosomal-based to a mainly protamine-based chromatin configuration [139]. In this respect, data from CB1-/- mice revealed the requirement of ES signalling for proper chromatin remodelling during spermiogenesis [117], and production of high-quality spermatozoa [140]. In fact, the genetic ablation of the CNR1 negatively affects the chromatin packaging, by affecting the content of TP2 mRNA and reducing histone displacement, with consequences on chromatin condensation and DNA integrity in the spermatozoa [117], which exhibit nuclear size elongation [140]. Such a mechanism is reversed by oestradiol administration, a treatment promoting histone displacement and chromatin condensation rescue in epididymal sperm collected from knock down animals [120].”
“The ES is an almost ubiquitous cell signalling system regulating several processes inside cells that are not yet completely understood. From its discovery in 1990s, it was clear that this system could be modulated by both extrinsic (cannabis and its derivatives) and intrinsic (the endogenous ligands) signals. Subsequent studies pointed out that the ES is much more complex than was thought since it is able to cross-talk with many other transduction cell signalling pathways, therefore regulating key biological processes such as cell proliferation and differentiation, synaptic plasticity, gametogenesis, and fertility. From the data herein reported, it emerges that epigenetic modifications of the ES by means of DNA methylation, histone acetylation/deacetylation at the CNR1, and FAAH genes encoding the CB1 receptor and FAAH hydrolysing enzyme may play a relevant role both in physiological processes regulating (male) fertility and reproduction as well as in disease pathogenesis and progression including cancer. Interestingly, it has been documented that external epigenetic cues such as alcohol induce DNA methylation changes in the mouse model of foetal alcohol spectrum disorder, and the lack of a functional CNR1 gene protects against ethanol-induced impairments of DNMT1, DNMT3A, and DNA methylation [49]. This suggests that the ES itself may act as an epigenetic signal regulating gene expression. On the other hand, the altered DNA methylation of both GPR55 and CB1 encoding genes, resulting in increased expression of GPR55 and reduced levels of the CB1 in CRC patients [58], also supports the hypothesis that the ES receptors could behave either as tumour promoting or tumour suppressor genes depending on the kind of epigenetics changes they undergo. The ES has been recognized as a strong modulator in the central and local control of reproduction in both sexes. It is involved in the regulation of HPG axis, successful gametogenesis, fertilization, and embryo implantation and development. Therefore, it is conceivable that environmental factors, by epigenetically affecting the ES, could induce adverse effects on reproductive system functions per se or alternatively, change gene expression profile with a transgenerational inheritance in the offspring. Within this context, the emerging literature tags the ES signalling as critical for the integrity of the epigenome in the sperm suggesting the possibility of a paternal epigenetic inheritance in the embryo through a process in which spermatozoa act as vectors for delivering epigenetic marks into the developing embryo, and in our opinion this is a very interesting issue that has to be further studied.”
What does 2-73 do? Hmm better let another company connect the dots I guess... better not anger the powers that be.
“I don’t know” said the man with all the answers. If we don’t have the answers, how will we ever know?
Toe to toe , like David and Goliath ... we all know who threw the stone.
Endocannabinoid modulation is KEY. Prove me wrong.
If the company ignores it’s mode of action... other’s will surly pick up that major shortfall.
No reason to be afraid of “stigma” .. science is science.
I agree 371%
“With Anavex drug candidates targeting the sigma-1 receptor, and with the mechanism of action being further validated, we are even more encouraged to advance our studies with additional neurodegenerative diseases,” said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex. “The Company is intrigued to realize the direct link to the body’s endocannabinoid system and to proceed with potential studies with our sigma-1 drugs candidates and cannabinoids.”
https://www.anavex.com/anavex-encouraged-by-scientific-data-confirming-sigma-1-receptors-beneficial-direct-interaction-with-cannabinoid-receptor/
Do you believe they still have a future? If so, when?
Watching
... not for long indeed
This sleeping giant just opened a few eyes
As well as prime numbers ...
73, 71
Indeed we do
“Walked away”? ... hmm missed that PR
You may want to double check that mate
Facts = speculations
14’s today imo
Wild and crazy! Just how I like it
Looks great here long term IMO
$AVXL
Interesting
May start a position soon.. need more DD
Good luck everyone $BCRX
SAVA and AVXL have similar science.
I feel both have good chances.
https://www.biotechtoinvest.com/research/2020/9/15/all-roads-lead-to-rome-compounds-from-avxl-and-sava-likely-target-the-same-sets-of-molecules
Patience And
Perspective ! $SAVA
Can’t sleep
But! I believe $AVXL might help with insomnia as well...
Jmho
Patience and
PERSPECTIVE
Bodes well for all endocannabinoid science IMO
Old news but company is making new waves with $Sava’s news
Interesting science to watch imo
$AVXL
http://www.anavex.com/wp-content/uploads/2021/01/Anavex-Presentation-January-2021.pdf
https://journey.ct.events/view/b2de0031-9eac-4cef-895c-454527e467cf
https://www.anavex.com/anavex-encouraged-by-scientific-data-confirming-sigma-1-receptors-beneficial-direct-interaction-with-cannabinoid-receptor/
Hurray for out of the box thinking!
Systems theory continues to prove correct imo
New age in medicine is SO close.
What is Anavex?
Why is it so awesome?
Any idea why it’s down so much today?
Long $CURI
7’s here we come imo
Good luck everyone $AVXL
Great Dividend*
$MPW
Absolutely love this one
Long $MPW
Great suv ended too imo
I believe so
Month maybe
Jmho
Looking good here imo
Good luck everyone $MJ
Looking good here imo
Good luck everyone $CLII
Looking great here imo
Why doesn’t this board have the ticker symbol? $FAMI
Looking great .
Can’t wait to hear about the “undisclosed” rare disease
Good luck everyone $AVXL
Patience And
Perspective
A lot of faith here.. but I feel it’s well placed.
This company has more than enough capability to turn around.
I’m Long.
All just my honest opinion.
Good luck everyone $GME
Patience And
Perspective
It’s better if you put the data on a far wall and squint.
Sounds like you really know the science!
Biogen was wasteful and bought plenty of lunch.. they are now being forced to stay at the little privileged kids table and finish feeding their food to the sheep before moving to second grade.
Biogen can barely afford (time and money) to deal with its own insanity, let alone broker a deal of this magnitude. I doubt Missling would balk .. more likely he said something like “thanks for the offer but I can’t in good faith to my shareholders take that small of a number until I know more about our pipeline.” The end. I don’t believe management would even consider a full on buyout right now.
Likely a non event but in any case Missling designed a poison pill for us shareholders to vote on, it passed, and ever since it’s been full steam ahead.