Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Risant Health seems to be a marketing strategy to attract new customers. Perhaps it will improve patient outcomes. I’m cynical when it comes to deciphering healthcare industry motives. Not a lot of transparency.
That said, while I don’t really understand why KP undertook the MITIGATE trial, I’m also fairly confident the results were positive. The objectives of the accounting department running business computer models is not necessarily aligned with the marketing department.
To paraphrase Benoit Blanc in the Glass Onion, “It is a dangerous thing to mistake facts for personal attacks”.
Kaiser has no incentive, it seems to me, to reveal RWE data on Vascepa, especially if positive. All that would do is socially pressure them to prescribe more of the drug and increase their costs. It’s unclear if longer living heart patients really helps their bottom line. I will be surprised if KP ever releases MITIGATE results for the same reason. KP is an insurance company, not an academic institution or drug company.
Good grief!
The Gateway Pundit (TGP) is an American far-right[2] fake news website.[1] The website is known for publishing falsehoods, hoaxes, and conspiracy theories.[34]
There is some research suggesting lipophilic statins may contribute to Alzheimer’s.
https://www.uspharmacist.com/article/some-statins-appear-to-increase-dementia-in-patients-with-mild-cognitive-issues
I guess a benefit of the combo pill is maybe Vascepa can offset the dementia from statins.
https://www.uspharmacist.com/article/some-statins-appear-to-increase-dementia-in-patients-with-mild-cognitive-issues
MAG-EPA is available as a dietary supplement.
From National Cancer Institute.
An eicosapentaenoic acid derivative with potential antineoplastic activities. Upon oral administration, eicosapentaenoic acid monoacylglyceride (MAG-EPA) may inhibit epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR) and serine/threonine protein kinase AKT (protein kinase B)-mediated signaling pathways and reduce vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1-alpha (HIF1-alpha) expression levels in tumor cells. This may promote apoptosis and inhibit tumor cell growth in cells expressing EGFR, AKT, and VEGFR. MAG-EPA may also inhibit androgen-stimulated tumor cell growth and repress androgenic induction of prostate-specific antigen (PSA) expression. PSA, a tumor associated antigen (TAA), is expressed by prostate epithelial cells and is overexpressed in prostate cancer. The AKT signaling pathway is often dysregulated in cancer and is associated with tumor cell proliferation, survival and migration. EGFR and VGFR are receptor tyrosine kinases that are mutated or upregulated in many tumor cell types and play a key role in tumor cell proliferation and tumor vascularization.
Dayspring should know better. He’s a retired lipidologist.
https://www.linkedin.com/in/thomas-dayspring-md-facp-fnla-3aaa876
More common side effects from Canagliflozin. Roughly 15% RRR. For patients with diabetes and renal problems. And why did you include it in the discussion? SMH.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Bladder pain
bloating
bloody or cloudy urine
decreased frequency or amount of urine
difficult, burning, or painful urination
discharge with a strong odor from the penis
frequent urge to urinate
increased thirst
increased urge to urinate during the night
indigestion
itching of the vagina or outside of the genitals
loss of appetite
lower back or side pain
nausea
pain during sexual intercourse
pain in the skin around the penis
problems in urination or increase in amount of urine
redness, itching, or swelling of the penis
swelling of the face, fingers, or lower legs
thick, white vaginal discharge with mild or no odor
trouble breathing
unusual tiredness or weakness
vomiting
waking to urinate at night
weight gain
No, the bottom line is:
“Cardiology, where science goes to die”.
Apparently you are out of touch regarding the prevailing trend of science denialism amongst both the mob and the elite, some of whom populate this board.
You don’t actually believe Dr Tinfoil and his admirers will change their positions given more data do you?
REDUCE-IT is well validated by the totality of scientific research. I’m sure you know that.
The real question is, why don’t cardiologists do everything they can to evaluate and treat their patients? Can you imagine going to a cancer doc, only to be told, “Looks like you got a lump there. Come back in a few months and we’ll see how much worse the pain and bleeding have gotten.”Meanwhile, let’s prescribe generic Locancia”.?
The China Study upon which “Forks Over Knives” is in part based was a piece of crap pseudo research that selectively chose data to support the author’s desired conclusions.
Eat a balanced diet, avoid processed “foods”, minimize sugar in its various forms, and avoid so-called vegetable oils.
https://deniseminger.com/2010/07/07/the-china-study-fact-or-fallac/
Mediterranean diet seems to be good for most people. “Forks over Knives” is based on junk science.
https://www.doctorkiltz.com/forks-over-knives-debunked/
Probably had normal cholesterol levels…
https://people.com/tv/lance-reddick-cause-of-death/
SanDiegoLiving on Stocktwits talked to Dr. Ambrosy who told him the MITIGATE results are “medically embargoed”.
What?!! You aren’t fluent in bafflegab?
Good one!
Very good article. Good luck finding a clinician with this depth of understanding and insight. Thanks for posting. A key quote:
“Tragically far too many clinicians are too focused on LDL-C and do not use the rest of the profile. That shortcoming is a big reason why patients are so under treated in the US.”
The heart attack industrial complex is terrified that their pet theories, mostly focused on LDL-C and various treatments including statins, PCSK9 inhibitors, and now Bempedoic acid might soon unravel. The unexpected success of REDUCE-IT was the first shot over the bow. I’m especially disappointed in Dr. Bhatt who can’t seem to get it.
Kiwi?
Study Officials:
Cynthia M. Carlsson, MD MS
Principal Investigator
William S. Middleton Memorial Veterans Hospital, Madison, WI
1) Her name is NOT stricken though.
2) William S. Middleton Memorial Veterans Hospital, Madison, WI (Mr Middleton is the name of the hospital!!!!)
You might not notice Aunt Josie’s decline over 6 years, but I’m sure cognitive tests for Alzheimer’s will detect subtle changes.
Wasn’t the STRENGTH trial stopped for futility? Was it done by the DMC?
From what I understand, it’s not “that” DHA.
Agree, if BRAVE shows virtually any positive results, the fish oil shelves will be emptied. The fish oil companies will make a double killing, financially and by providing no therapeutic benefit.
If BRAVE shows Vascepa delays onset of Alzheimer’s by 5 years, demand will outstrip supply.
iHub downloaded your membership to “skinny”.
Thanks. Good article.
I believe arterial inflammation is caused by oxidized or otherwise damaged lipoproteins. Vascepa prevents lipoprotein damage. Statins lower LDL-C, some of which is damaged, but probably doesn’t do much beyond that. Consequently, people with “normal” LDL-C may have CVD. Vascepa reduces the root cause of atherogenic properties of LDL-C.
Injuries, burns, bruises, and other physical trauma trigger release of histamines which activate the immune system. Treatments that inhibit cell damage from histamine release such as ice are effective in reducing the inflammation. Vascepa would be of little use.
Not totally. Paint eventually does dry.
I had to stop taking 10 mg Lipitor due to a Rhabdo. Fortunately I recognized the symptoms immediately.
Hard to believe any competent Dr would prescribe that crap (colchicine) for CVD when there are plenty of more effective and less toxic therapies.
https://en.wikipedia.org/wiki/Colchicine
Perhaps they will report it on one of their endless post trial papers.
Chart appears to be about 7 years old. I think the wishy washy note on inflammatory biomarkers re CVD could be updated.
It seems clear from a number of studies that Lp-PLA2 should be grouped with the atherogenic biomarkers. Also should differentiate between systemic inflammation (hsCRP) and arterial inflammation (Lp-PLA2).
https://www.lifeextension.com/magazine/2008/11/detect-risk-of-sudden-heart-attack-stroke
Got it. Thanks.
Get a 404 error on my iPad. Board posts aren’t showing when I log into website.
If you have time and so inclined, a simple chart showing hsCRP and Lp-PLA2 for the MARINE, ANCHOR, and REDUCE-IT trials would be of interest. Whereas hsCRP is a marker for systematic inflammation, Lp-PLA2 is a more direct marker for atherosclerosis. So far, I haven’t found where anyone has published Lp-PLA2 results for REDUCE-IT though.
https://link.springer.com/content/pdf/10.1007/s40256-012-0002-3.pdf
Are you on an Aetna Medicare Advantage plan? My plan only has Brand Vascepa on the formulary. I intercepted an attempt by the pharmacy to give me IPE and had them switch to Vascepa. In the meantime the pharmacy had submitted the IPE to Aetna and they sent me a notice saying they’d pay just this one time. Haven’t had trouble (yet) getting Vascepa covered.
.8
Lp-PLA2 = 43 nmol/min/ml (vs. <75 optimal). hsCRP can be elevated for a number of reasons. Lp-PLA2 is associated specifically with atherosclerosis.
https://www.lifeextension.com/magazine/2008/11/detect-risk-of-sudden-heart-attack-stroke
PROMINENT, REDUCE-IT & STRENGTH trials.
“More than half of the trial participants had hsCRP ≥ 2 mg/L. This criterion alone put them at greater risk of MACE, CV death, and all-cause death, irrespective of whether they had an LDL cholesterol ≥ 70 mg/dL.”
Perhaps U should revisit your LDL fixation. What is your hsCRP?.
I believe Ridker has some patents around hsCRP and I seem to recall his benefiting financially from royalties.
Despite much research on IPE being a powerful anti-inflammatory, he neglects to mention this. hsCRP was reduced 36% in the MARINE trial and 22% in the ANCHOR trial.
In his suggestions for addressing inflammation, he does not mention IPE.
How are you doing on the assignment i gave you?