Life long Maverick: Seen it ALLl in 40 yrs of PROF. exposure as invest analyst/port mgr on the FRONT lines vs iHub Msg Bds.
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The Citadel Link: What Ken Griffin Has to Do With GameStop ["https://www.bloomberg.com/news/articles/2021-01-31/the-citadel-link-what-ken-griffin-has-to-do-with-gamestop"]
Different Strokes for Different Folks!
Titanic Monetary Battle of Many $Multi bln SHORT Hedge Funds using Wall St as their private casino and finally losing.......
vs GenX'ers, Millennials (Occupy Wall St) anti establishment via Robinhood/Reddit /WSBets Apps funded by prominent Silicon Valley Venture Capitalists....
Combined with the latest GameStop institutional ownership:
https://money.cnn.com/quote/shareholders/shareholders.html?symb=GME&subView=institutional
Another example of The EXTREMES of Capitalism
Not surprised that tenacious & ingenious Elon Musk twitted late yesterday as he went thru HELL for years battling SHORT Hedge Funds to become world's wealthiest:
The DISRUPTOR on many fronts vs Establishment.
Fortunately Robinhood raised OVERNIGHT $1 bln from their VC's to continue trading & funding their customers to meet major Financial Regulatory requirements due to GME, AMC, Bed Bath & Beyond ETC!
MORALE worth repeating:
Two Edge Sword with LEVERAGE via MARGIN Account and especially OPTIONS as witnessed by many here losing A large WAD on NWBO AND AMRN whether on Margin or playing Options which too many have experienced
Covering the BIG Picture versus a segment.
This is not going to end nicely IMHO.
DIFFERENT STROKES FOR DIFFERENT FOLKS
Reefrad
https://www.bigislandvideonews.com/2020/12/31/kilauea-volcano-eruption-update-for-thursday-morning/
BTW
RESULTS are ALL that Matters:
"A recent $600.00 Direct Deposit posted on Jan 1, 2021 at 6:04 AM ET"
AND I have already used the $600 in last 10 days to STIMULATE the USA economy which HELPS!
versus most will be Saving it (Darker days ahead) or pay mounting in ARREARS RENT,CAR Payments, or Put Food on Table.
AND Don't blame others for YOUR Responsibilities!
RESULTS and Getting the Job DONE
are ALL that Matters in Life!
DIFFERENT STROKES FOR DIFFERENT FOLKS
Happy New Year to ALL
Iwasadiver is always a NEEDED Breathe of FRESH AIR with his demonstrated many degrees of freedom, well grounded, diverse entrepreneurial background and wide range of contacts cited as well as being a cherished front liner dealing with The PANDEMIC at a number of facilities and his needed reading between the lines which he liberally expounds on unlike what's been seen here: (black & white: NO shades of gray... closed mindsets without the wide array of occupational exposure to deal with this EPIC SAGA).
What Iwasadiver says below I have wholeheartedly endorsed (in red below) for at least the last few yearS!
Impending TSUNAMI alert:
What the hell, since the time window is SHRINKING, I can now afford a possible blemish after 6 years of undeserved ridicule, disrespect by this vitriolic board.
This is a bit out of character for me but this is what I sense:
I am going out on a limb by expressing the following:
IF CEO Linda Powers can structure a Compensation Package skewed to Grid Granting Options(may be a tall order but she's been adept at every known undertaking to SUCCEED!)acceptable to departing Merck's EVP Roger Perlmutter ($9+ mln salary)to be new CEO, while CEO Linda Powers retains her role as Chairperson and controlling person.
Don't think that MRK's EVP Roger Perlmutter is retiring yet.... despite his already monumental achievements for both AMGN (Roger left in 2011 and made it the largest biotech company) and since 2012 went back to MRK (Keytruda from zero to over $9bln and going to $24 bln by 2024!) which I have already profiled over a year ago.(See link in replying post)
This will be for The Greater Good for ALL parties......then it will be a WIN WIN:
The above is SEPARATE from any possible:
1) MRK cash infusion or equity ownership via Licensing/Partnership agreements with Milestone markers.
This has been MANY MANY years in the Making IMHO.
But FIRST and FOREMOST DCVAX L Top Line Data! (TLD)
ALL of the above is IMHO to be followed up shortly AFTER disclosing TLD for that positive TSUNAMI crescendo wave to herald the arduous legendary lifelong work of both NWBO CEO Linda Powers (From TWICE near ASHES to The PHOENIX) and equally that of UCLA's Dr. Linda Liau PhD, MBA. Both dedicated their lives to solving the unmet medical need for treating GBM, the most aggressive of cancers!
SHOULD ALL of what I postulate above transpire in a TIMELY manner, there should then be for the maligned pink sheeted NWBO an instant reversal in market credibility unlike the years of what Elon Musk underwent with TSLA .
Fortunately for us, CEO Linda Powers, by choice, elected to have the opposite profile (SECRETIVE):versus that of the high profile of the now second richest person on this planet Elon Musk.
That is what I perceive is happening behind the curtain in the CLANDESTINE world of CEO Linda Powers always having lots of irons in the fire and driven to succeed regardless of the insurmountable odds. Same can be said about UCLA's Dr. Linda Liau.
The above RESOLVES BUNDLES in one move.
Let's hope there is a meeting of the minds of these two respective TITANS for The Greater Good of Society.
DIFFERENT STROKES FOR DIFFERENT FOLKS
NOT taking questions on this:
For your CONTEMPLATION
MSFT Windows: Altho I own MSFT, gave up using Windows since 2015: too many complex integrating software issues and most especially security issues causing functional operating issues especially as it relates to viruses! Malware ETC
WAS a MacBooks user since 2014 and have most every Apple pdt but like too many others... experiencing iPhone battery drainage issues re latest IOS releases ... as a participant in Class Action Apple iPhone Settlement.... and have abandoned Apple pdts!
Going on close to a year ago adopted
1)Brave browser now acclaimed for PRIVACY/CUSTOMIZATION/SPEED.
2)VPN Surf Shark
Have tried every Browser since 2000 period.. even Opera!
To replace my iPhone and use of MacBook got highly rated OnePlus! WOW
Been considering WHEN needed a gaming,light weight Laptop with at least 16 GB RAM using AMD Ryzen 4000+. But will delay purchasing both a 5G Smartphone and Laptop if needed until the pervasive implementation of 5G network!
Would if I had the expertise let alone time do LINUX!
Just today catching up on iHub posters:
Did my second massive purge to IGNORE list of even those from 2016 to new posters here.... like:
https://investorshub.advfn.com/Wall-$t-Banker$$-BANKZ-2832/
Life is way too complex to deal with the time intensive extraneous!
We are facing IMHO(based on lots of firsthand experiences for many years):
1)The EXTREMES of Capitalism with the 1999 Repeal of The Glass Steagle Act of the late 30's Depression Era.
2)The Beginnings of APOCOLPTIC times
Ie: https://weather.com/science/environment/video/arctic-getting-greener-is-cause-for-concern?pl=pl-the-latest
FYI: https://investorshub.advfn.com/boards/profilea.aspx?user=486527
TCTrader's reappearance under CrazyBilly is a sight for sore eyes!
The whole enchilada vs hairline fragments!
DIFFERENT STROKES FOR DIFFERENT FOLKS
Pandemic re China & Dendritic Cell re Immune System research in China:
"GINORMOUS" Mkt Opportunity
Comprehensive Nature article :
Inside China’s response to COVID
https://www.nature.com/articles/d41586-020-03361-7
with FWIW illuminating passage:
Anders et ALL in thread re:
INTRIQUING that NWBO may likely have a similar recent experience and trajectory from many vantage points of:
https://trilliumtherapeutics.com/
Invariably I do get the last laugh:
For NWBO: since 2014!
DIFFERENT STROKES FOR DIFFERENT FOLKS
https://www.cbsnews.com/video/covid-long-haulers-60-minutes-2020-11-22/
Illuminatingly mortified by the effect on even under 40 yr old NYC Marathoner!
Even after 6 months ....
UNCERTAINTY at NYC Mt . Sinai Covid-19 rehab.
UNDERSCORES how each should BE VIGILANT and Conservative in applying Dr. Fauci's protocols!
DIFFERENT STROKES FOR DIFFERENT FOLKS
Merck acquires OncoImmune to ramp supply of promising Covid drug
PUBLISHED MON, NOV 23 2020 6:46 AM EST UPDATED AN HOUR AGO
Meg Tirrell@MEGTIRRELL
The medicine, called CD24Fc, was shown to reduce the risk of respiratory failure or death by more than 50% in patients hospitalized with Covid and requiring oxygen
The $425 million deal comes with the potential for additional payments based on certain regulatory milestones.
But Merck only gains CD24Fc; OncoImmune will spin out other rights and assets into a new company, into which Merck will invest $50 million.
A medical staff member treats a patient suffering from coronavirus in the COVID-19 intensive care unit (ICU) at United Memorial Medical Center on November 16, 2020 in Houston, Texas.
A medical staff member treats a patient suffering from coronavirus in the COVID-19 intensive care unit (ICU) at United Memorial Medical Center on November 16, 2020 in Houston, Texas.
Go Nakamura | Getty Images
Pharmaceutical giant Merck said it plans to acquire privately held OncoImmune for $425 million in cash, gaining rights to an under-the-radar drug that has shown striking results in hospitalized patients with Covid-19.
The medicine, CD24Fc, was shown in a late-stage clinical study in September to reduce the risk of respiratory failure or death by more than 50% in patients hospitalized with Covid-19 and requiring oxygen, Merck said Monday.
The drug was given as an intravenous infusion in addition to standard-of-care, which could include remdesivir and dexamethasone, and was compared to standard-of-care alone. The data, in 203 patients, also showed that patients receiving CD24Fc had a 60% higher probability of seeing improved clinical status.
“The results are remarkable,” Merck’s research chief, Dr. Roger Perlmutter, said in a telephone interview.
With cases of Covid averaging almost 170,000 a day in the U.S. and a record number of people in the hospital with the disease, a drug that could significantly speed recovery and reduce the risk of death or of patients getting so severely ill they require ventilators could make a major difference in the pandemic.
But there’s a problem: supply.
“We realized that this small little company was in no position to make CD24Fc to try and treat all of the people who could potentially benefit from this drug,” Perlmutter said. “We decided that the only way, seriously, that this could be brought to people who need it is for us to lean in with our capabilities.”
Merck plans to shift some of its manufacturing capacity to start making the drug. But it’s a complex medicine to manufacture and it will take time. Perlmutter said he’s aiming for “before the middle of next year, and ideally much before that,” for there to be ample supply.
OncoImmune, founded and helmed by Yang Liu, director of the Division of Immunotherapy at the University of Maryland School of Medicine, reported the top-line results from the trial on its website in September. They haven’t yet been published in a peer-reviewed journal. Merck says submission of detailed results is coming.
Though the findings caught little of the world’s attention, one person who did notice was Moncef Slaoui, chief advisor to the U.S. government’s Operation Warp Speed. He noted in a telephone interview on Nov. 1 that the data for OncoImmune’s drug have “just been incredible,” noting a “relative mortality impact that’s very clear.”
Slaoui explained the drug prevents the immune system “from being hyper-activated.” It’s the same reason the steroid dexamethasone proved so effective in a trial in June at treating patients in more severe stages of Covid-19; when patients become that sick, it can be their own immune system kicking into overdrive that causes problems, not the virus anymore.
“Frankly, nobody would have believed that it would have this kind of effect,” Perlmutter said, when asked why the CD24Fc results garnered so little attention. “If you look at the other anti-inflammatories that have been studied in very ill Covid-19 patients, it’s been hard to show there’s any effect at all.”
In addition to the potential to help with the pandemic, Merck acquired OncoImmune because it sees possibilities for CD24Fc beyond Covid. It has shown promise for graft versus host disease, a dangerous immune reaction that can happen after bone marrow transplantation, and Perlmutter said it may have further applications as well.
The $425 million deal comes with the potential for additional payments based on certain regulatory milestones. But Merck only gains CD24Fc, while OncoImmune will spin out other rights and assets into a new company, into which Merck will invest $50 million.
The company doesn’t plan to seek emergency use authorization from the Food and Drug Administration until it has enough supply of the medicine for people to actually use it, Perlmutter said. That’s now the task for Merck — which is also developing a pill for Covid as well as two vaccines for the disease.
“Now that we have this terrible, terrible surge in Covid-19 cases, and so many people are hospitalized in severe or critical condition, and so many people in ICUs, tens of thousands, or potentially hundreds of thousands or more just in the United States might need this drug,” Perlmutter said. “We’re going to move heaven and earth to produce the material.”
NWBO has been on the top shelf for MRK since pre ASCO 2019! per eyewitnesses verifications by attending oncolgists AlphaPuppy and Photonic5 per my posts.
DIFFERENT STROKES FOR DIFFERENT FOLKS
Decades of EARNED CLOUT in Small Emerging Growth Co's via Gramercy Capital MGMT managing public pension money!
Likewise for miraculous story behind $MGR of Michael Bloomberg who began managing All stock trading of former Salomon Bros who I worked for (acq by Citigroup).
PREFACE:
Joan lived in Manhattans Gramercy Park area by East Hi Teens by 3rd Ave.
My favorite Sporting Goods store Paragon Sporting Goods that carries all the best has always been a big fixture (check it out online vs your favorite vs NYSE Dicks (perfunctory but successful blossomed from where my deceased parents were since 1970's).
Sadly across town Barney's another of my favorites in 1970's is now shuttered worldwide courtesy of Mr. Pressman who outfitted me, let his sons take it thru at least 3 bankruptcies by large international consortiums: worldwide overexpansion in Ultra high rent locales!ie Rodeo Dr. Beverly Hills etc.
Joan Lappin( began as a media analyst with NYC's acquired pre 2000:Bankers Trust; Manufactures Hanover banks
Here's Joan Lappin's sequel follow-up:
DEDUCED RECKONING: Northwest Bio awaits trial results
BY JOAN LAPPIN | SARASOTA HERALD-TRIBUNE | 13 hours ago
Doc_Logic re:
Flipper's reply with post Oct 2015 mentioning MRK/BMY re Checkpoint Inhibtors:
Flipper just covering the bases BUT NONE of it resulted in anything material to NWBO TO DATE!:
1)ALL of it stalled! and nothing of significance to date by EITHER
2)More important NWBO price since Oct 2015 went from one of the unstable precipices of the Grand Canyon
shattering from ~$4.5-$5.0 to present levels of $1+ or - 73%
Meanwhile the XBI (small biotech index) ROCKETED: +57% during the same time period !
MEANS NWBO UNDERPERFORMED with XBI benchmark by 130%
MOREOVER if INSTEAD of
1) Neil Woodford who literally was the prime mover in moving NWBO from $6 to over $10+ which none foresaw.
2)The Baker Brothers would have clearly produced the OPPOSITE POSITIVE IMPACT as evidenced by one of their sample holdings:
SeaGEN or known as Seattle Genetics (SGEN):
The Baker Bros have been historically SGEN's largest institutional holder currently holding 35% of ALL institutional holdings. AND they have board representation!! and participated in many aftermarket offerings to MAINTAIN their position as the largest institutional holder.
AND SGEN since Oct 2015 has ROCKETED from $40-$170+
Same can be said of MRTX
As I have been indicating the above should have been self evident:
NEOPHYTES have been deceiving themselves and others since 2015 in this EPIC SAGA. of:
1)WRONGLY believing Neil Woodford would be the long term financier for NWBO.
2) Violation of not taking profits when they should have.
2) Limiting one's losses to preserve investment capital
3) Not believing there ARE Dark NEFARIOUS MARKET MANIPULATING Forces.
4) Calling EVERY NWBO CRITICAL Stock Inflection point WRONG!
It has taken MORE than most ever thought as FEW had the depth of expertise to uncover what was
really happening .
BIG piles of $ for years were submerged at the bottom.
Many lost a large part of their life savings with the cult like euphoria evidenced.
At this END stage, most all will look like a hero!
DIFFERENT STROKES FOR DIFFERENT FOLKS.
Re Beachhyena
The MADDENING CROWD here and How to be WAY AHEAD of The CURVE!:
Since most of you are TETHERED to ONE stock AND needed to be REMINDED on 1)Big Fish MRK's EVP Roger Permutter is leaving MRK and his PLANS?
OR
2) Who is Dr. Carlo Rago?
The OPTIMAL END GAME is what happened to GENETECH!
IF you cannot parse the above by yourself, then you are still a "Babe in the Woods" or mired in THE SWAMP based on what has pathetically evolved (NWBO struck by Metorite ala Neil Woodford....CRATERING since 2015! that NONE here FORESAW except moi!(Demonstrated closed mindsets since 2015, along with being decked out thru Summer 2020....believing you had a full house of cards
PATHETICALLY MYOPIC: par for the course
Regardless:
Under the SUPERB leadership by CEO Linda Powers avoiding TWICE near ASHES to the PHOENIX along with the amazing three decade work by UCLA's Dr. Linda Liau AND with MRK's assist on MANY fronts before year-end 2020 IMHO will NWBO shareholders have some armor from the following:
We are seeing the beginnings of APOCALYPTIC TIMES courtesy of The EXTREMES of CAPITALISM (It all started back in 1999 with the repeal of the Glass Steagle Act which was championed by then Citigroup CEO Sandy Weil that lead to "Free Markets will take care of themselves ala Former Fed Chrmn Alan Greenspan etc"......TOXIC derivatives, sub prime mtgs..... resulting in 2008 Financial Collapse and the Crushing of the Masses:
No matter where on this planet it is about:
GREED; CORRUPTION ; and WORSE: ABUSE of POWER
Be the Master of your Own Destiny! by zigging and zagging versus being strait jacketed!
This is all my humble opinion.
Invariably I do get the last laugh
DIFFERENT STROKES FOR DIFFERENT FOLKS
Up Listing article maybe DUBIOUS:
Looks like INCOMPLETE Due Diligence by Inspector Clouseau?
Appears that author LIKELY same as :
https://smithonstocks.com/northwest-biotherapeutics-nwbo-buy-6-75-responding-to-serious-unsubstantiateRICK PEARSONd-allegations-by-richard-pearson/
https://www.google.com/search?safe=active&client=ms-android-tmus-us-revc&sxsrf=ALeKk0006xXDBGXmIR7_M7kglYysw91KKA%3A1603222258024&ei=8jqPX757-s_Q8Q_69ZSoBQ&q=RICK+PEARSON+%2B+seeking+alpha&oq=RICK+PEARSON+%2B+seeking+alpha&gs_lcp=ChNtb2JpbGUtZ3dzLXdpei1zZXJwEAMyBQghEKsCOgQIIxAnOgIIADoGCAAQBxAeOgUIABDJAzoECAAQQzoJCAAQyQMQFhAeOgYIABAWEB46BQghEKABOgcIIRAKEKABOggIIRAWEB0QHlD03QFYip8CYOS1AmgAcAB4AIAB0AGIAb8UkgEGMC4xNS4ymAEAoAEBwAEB&sclient=mobile-gws-wiz-serp
That Rick Pearson is NOTORIOUSLY prolific in
Adam Fraudstein like HIT pieces re Emerging Biotechs
The mental recall and memories here leaves a lot to be desired and spacey IMHO
On track for yet another day of FLUSHING OUT
the toilet bowl.
DIFFERENT STROKES FOR DIFFERENT FOLKS
For NEOPHYTES: Yet ANOTHER Needed Blood Transfusion.
OUT with the OLD and in with BIGGER Players to dictate vs the daily posted clear insecurities of those who are tethered multi year NWBO posters missing ALL the Curves in this truly EPIC SAGA . even confounded those who practice this professionally as oncologists.. forget about posters! and their supposed specialty:
NWBO from TWICE near ASHES to the PHOENIX:
ALL because of the superb stewardship, life long dedication of both CEO Linda Powers and that of UCLA's Dr.Linda Liau in extending the 2011 Nobel Prize work in Dendritic Cells by deceased Canadian Dr Ralph Steinmann of NY's Rockefeller University:
https://en.wikipedia.org/wiki/Ralph_M._Steinman?wprov=sfla1
BTW, never surprised here, that NOBODY 2 years ago indicated or picked up the involvement of Joan Lappin in the NWBO private placements whom I've known via her earlier affiliations with BT or Mannie Hannie.
NEW and less tumultous BALL GAME.
But it will not stop those posters from "machinations inducing massive perspirations from the small stuff"
Few have the wherewithal to fathom what both these becoming legendary women have overcome and WHY they remain SECRETIVE!
Few,if any, can pierce through the cover-up's here, or the financial graves with this EPIC SAGA...only DT has so far has some success!: his daily attire destined to wide stripes
Invariably I do get the last laugh!
DIFFERENT STROKES FOR DIFFERENT FOLKS
SUPERB Sleuthing vs all the pre 2018 high profile prolific scientific posters in NOT uncovering what was KEY to
Clearly REVISED SAP approved by all 4 Regulatory Agencies many years ago.
SAME analogy applies to ALL those other NWBO super critical historical inflection points:
1)Why buy Sawston, UK: weeks of lots of flack/consternation/bewilderment
2)Why biggest NWBO lawsuit emanated from UCSF: UCSF felt threatened.. lots of illustrious alma mada types in IMMUNIOLOGY like Merck's EVP Roger Perlmutter etc etc
3)Why CEO Linda Powers secured husband and wife team (CLONES of her to fill the dual roles of prep and fill up senior mfr ranks of Cognate BioSciences that was sold on a MBO!
4)Why no one in the UK ever posted about the sheer concentration of Chinese mainlanders both having their bright one's studying at Oxford Univ and owning real estate nearby to result in Huawei building their largest non China campus via CEO Linda Powers pulling out the BIGGEST of many rabbits Out of the Hat: her Biggest financial Saviour from Near Ashes
5)No others here even sensed Cognate BioSciences would be sold!
6)292,000 Well heeled UK investors got fully skunked and will not be able to source their DECIMATED funds till year end 2020 .. ALL caused by fully disgraced and supposed NWBO long term financier: Neil Woodford who received glowing adoration here!
7) Hats off to Longfellow's knight in shining armor in joisting AND verifying UK likely to give DC VAX L approval.
7) VP David Innes has no prior professional experience in the field of Investor Relations unlike what has been expressed: POSTED
9)BTW selling is NEVER a good nor reliable prognosticator re BasinStBLUES multi year torments here on CEO Linda Powers who did it for TAX Reasons by sustaining a GIGNORMOUS LT tax loss on NWBO to OFFSET her WHOPPING LT Gain on Cognate BioSciences: previously posted but BSB has been unaware or intentionally omits THE FACTS..not seeing The WHOLE LOAF (THE BIG PICTURE vs an incorrect vignette) has been my experience here since 2014. It's all in black and white for every poster.
The above are what comes to mind!
BOTTOM LINE!:
HISTORY has demonstrated that there are boatoads of ILL equipped NEOPHYTES with empty bravado and only posting on ONE company and rarely with supporting links .... GLORLLA glueD!
Some even said Corona Virus would not persist in tropics: see Brazil's Covid-19!
Obviously none of this could have been achieved if it wasn't for The SUPREME NAVIGATOR, extraordionaire... CEO Linda Powers who along with SVP Les Goldman have BOTH received SILOS of MANURE since 2015 and some even demanded her being ousted in late 2018-2019!
Moving ON vs dealing with recalcitrant, circuitous, deflections ala DT types!
NO major US Stimulus plan happening since late July especially as it relates to 5th largest economy that of traumatized California State, even NY State which the former had to raise their already highest personal income state tax rates is a harbinger of both The EXTREMES of Capitalism
are rampant where health care, housing and educational costs are financial crippplers causing this: The 50 Richest Americans Are Worth as Much as the Poorest 165 Million where 50% of US population only have 2% of all wealth re today's
US Federal Reserve:A MUST READ:
The 50 Richest Americans Are Worth as Much as the Poorest 165 Million "https://www.bloomberg.com/news/articles/2020-10-08/top-50-richest-people-in-the-us-are-worth-as-much-as-poorest-165-million"
DIFFERENT STROKES FOR DIFFERENT FOLKS
Touche Spartex in clearly debunking the prevailing conventional "wisdom" here, where those that post primarily on one or at best a few stocks, have been MYOPIC in ignoring CEO's Linda Powers ABATA address was VIRTUAL widely deployed in the last SIX months due to the PANDEMIC.
The above is CRITICAL in being AHEAD of The CURVE with a demonstrated lack of needed acuity and agility all of which has NOT been evident since 2015!in lining up CORRECTLY what is likely happening BEHIND the CURTAIN given the legalese and silent NWBO communiques that test both Longs, Shorts, and traders.
How many more revisions (no mea culpa's of accountability let alone atonement for massive devastation witnessed since 2015! speaks volumes) does it take even at this eleventh hour in this truly EPIC SAGA!
No riddles by moi... all in posted black and white.
AND with Merck's CEO press release re EVP Roger Perlmutter retiring the INTRIGUE builds!
https://www.businesswire.com/news/home/20201002005200/en/Merck-Announces-Retirement-of-Dr.-Roger-M.-Perlmutter-Dr.-Dean-Y.-Li-Appointed-as-President-Merck-Research-Laboratories
Following this thread of many others posted
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=151053330
AND
https://investorshub.advfn.com/boards/replies.aspx?msg=150971197
Should enlighten.
BTW I have receded in posting given the self inflicted damages in posterS NOT fully armoured to deal with this EPIC SAGA and the acrimony and contentious here was wrongly treated as personal attack versus business FACTS resulting in one post per day for INDEFINITY courtesy of The Inspector.
The EXTREMES of Capitalism model need redressing.
We are seeing the Beginnings of APOCALYPTIC Times: Stated with WHO declaration that Coronavirus is PANDEMIC: I stated...
WW Massive Economic DISLOCATIONS!
Thanks again Spartex!
DIFFERENT STROKES FOR DIFFERENT FOLKS
Fully agree thanks to Sojourner re:
Thank you ilovetech for Sharing ALL the highlights and granularity on your AMRN experience.
I have shared my own specifics in exactly the same manner (ALL inclusive which is truly a RARETY for both of us vs the all the multitudes on whatever social media platform) as you've just posted
Others pontificate,grandstand, bullying and deflecting to serve their own selfish agenda:
"Problem for Amarin, and why I stayed away from it, is regular fish oil works. There’s a reason they used mineral oil, and not standard fish oil as an active placebo. I know this because fish oil cut my triglycerides in half In just a few weeks. There might be a non-statistical Advantage of Amarin’s product over fish oil, but that should be a marketing advantage, not a prescription, insured, outrageously expensive therapy. Sorry, that’s my perspective."
In reply to SINGULAR anecdote above which had no links in support of his opinion:
Hopeforthefuture3
XXX may I suggest you do a little more reading into the amrn research, think you might change your perspective. Also check out the final results of the Evaporate trial
Good luck
On amrn webpage they also have full article link to the reduce-it trial
hump4
It's not quite that simple. Not everyone sees anywhere near those results on fish oil
What that self serving high horse bully pulpit posted deliberately OMITS the WELTER of FACTS:
For Vascepa, a patented Omega 3 with major differences and positive impacts due to it's high EPA concentration vs that of DHA has been heralded for the last six years by many hundredS of iHub AMRN testimonials!
To top it off that high horse posted OMITS what AMRN's Vascepa earned where no other "fish oil" could achieve( see below)
The real rulers as it relates to the efficacy of AMRN's Vascepa have been the clearly biased FDA .
Moreover one person's anecdotal of having positive results of using OTC Fish Oil supplements or Krill Oil truly is like The Emperor without clothes as seen in these links:
Re The American Heart Association:
Issued AMRN's Vascepa as Standard of Care by reducing Heart Attacks and Strokes by 25%
Re: The American Diabetes Association
https://www.medpagetoday.com/cardiology/prevention/82346
Re Lipids Association: .
My sixth sense about IMPENDING UPDATE & see my previous post MESSAGE
Thanks Iwasadiver for your kind words:
As Sojourner indicated NWBO hit 75 cts:
the typical healthy 30% retracement one would like to see of NWBO's CATAPULT from 35 cts from early September.
As previously posted I assimilated some technical tools of Hall of Famer, Dean of Market Technicians: Robert J. Farrell where we both worked at Merrill Lynch, now part of Bank America, courtesy of deposed former B of A over valued acquisition since The Great Recession during the reign of NY Fed Timothy Geithner who was the matchmaker and is now President of Warburg Pincus a Private Equity firm after serving as US Treas Sec during President Obama's 1st term.
AND BTW you will get a LOL:
https://www.thedrive.com/news/36651/theres-a-jeep-wrangler-dangling-off-a-cliff-in-california-after-some-fool-drove-up-a-bike-trail
I do get around and beyond investing:
Closest I've gotten to the above was driving on CA 2 to Mt Wilson Observatory 5500 ft elevation
https://maps.app.goo.gl/kcKs1haXYj2s8WiL9
which was recently besieged since early September by the still raging Bobcat fire, CA's 3rd Largest Wildfire, just East of LA.
As the cognescenti has been acknowledging:
CEO Linda Powers and Dr. Linda Liau .....
nor would 68 other prominent neuro oncologists leave US in that Jeep's state of bewilderment/amusement?
DIFFERENT STROKES for DIFFERENT FOLKS
Thankfully my NWBO Program OUTREACH (see below as I do GET RESULTS for The GREATER GOOD and not grandstanding or spinning like too many, have taken down too many on their high horses, including the whole posse of iVillage denizen of NWBO bear cubs and Always Go The Last Mile in any of my life's undertaking and everything I post is both verifiable, factural,( versus personal attack: BIG Distinction, yet no biggie.. can live with just one post daily on NWBO) and logically based on 40 yrs of front line PLUS engagement looking at the BIG Picture along with assessing the critical variables across many disciplines and worldwide:....and beyond investing!):
For verification just two samples many years ago:
maverick_1 Monday, 11/12/18 11:12:14 PM
Re: marzan post# 197033
Post # 197043 of 309987
NEEDED TRANFUSION HERE: Timely and Long OVERDUE
Wonders never cease as long as one BELIEVES ,is clearly able to communicate like I did outside of the confinement’s here to convey the FACTS on NWBO whether on AMRN ‘s board or Biotech Values as I was ambushed 24/7/365 by Exwannabe on the latter board vs the conflicting noise that has not in 5 + yrs amounted to anyone making any money here. Only LARGE realized or unrealized losses where the latter had to DIG DEEP in their souls AND their pocketbooks to lower their cost basis !
It is thru Marzan and a whole trove of AMRN investors is why NEW BLOOD was infused in recent years and ESPECIALLY since Sept 24 when our AMRN catapulted to the stratosphere all to keep CEO LP dreams and dedication alive even with dreaded dilution!
I have even conversed with two that EACH own close to a million shares of NWBO recently,
Thanks Marzan,
DIFFERENT STROKES FOR DIFFERENT FOLKS
From iHub AMRN board:
maverick_1 Sunday, 10/28/18 09:27:33 PM
Re:jessellivermore post# 152948
Post # 153074 of 300972
As I indicated to Marzan I'm up a few hundred K. Unlike Marzan I'm unleveraged: NO Call Options.
Wasn't my only issue to having scored over 100K in one issue. And one of those was a brazen call on my part, a SHORT that I made a name for myself amongst a core of high performance hedge funds when Iwas in my 30's.
The short close to doubled and generated a big call for funds. The reason it almost doubled: the partner in charge of research at Morgan Stanley was the drug analyst who wore another hat: IBK trying to raise funds for LVAD 20 yrs ahead of approval.; that company had another operation and competed against Goretex started up by DuPont ex patriates.
Put up the dough! Stuck to my convictions.
Shockingly after I interviewed a CEO he asked what I had in my portfolio! (That never happened in any of my company visits with managements!). He had a large short position in the same issue: a one in a million chance ! We compared and traded notes.Covered 1/4 at cost basis of $6.50. The rest covered close to bankruptcy at 25 cents.
Looking for similar like results as AMRN short term from an investment in NWBO whether thru top line GBM data and/or partnership.
Thanks JL for your creative clinical trial on Vascepa!
DIFFERENT STROKES FOR DIFFERENT STROKES
BTW just added more!
GLTA
Would doubt TLD will be Tues as Elon Musk's much delayed TSLA Battery Day and ASM will be a Ginormous Media DISTRACTION After Mkt hrs:
IMHO CEO Linda Powers will astutely avoid.
Those indicating otherwise have not consulted THE MARKET CALENDAR.
Used up my ONE post daily allocation!
DIFFERENT STROKES FOR DIFFERENT FOLKS
Thank you Thermoos for the ENLIGHTMENT and your posted "Real McCoy's views" and validation of my own privately held view of what you've expressed as I have, as posted, relatively recently intentionally removed myself from years of trying to instill the proper perspective here and elsewhere.
Too few acknowledge that in reality they do not understand the capital market process let alone the treacherously violitile emerging biotechs arena.
Do people change???
I have never lost a penny (being Long only in my six years into NWBO AND could have easily shorted it and made a huge bundle as I have done that with large hedge funds in 1980's). (hence:Maverick + Different Strokes for Different Folks which many have sneered at: Invariably I do have the last laugh!)
Should, as most expect, that TLD be a game changer warrant holders should then INFUSE $'s to NWBO..... possibly avoiding a large capital raise.
AND no or little sale of those converted warrants to common shares.....
should make it HARDER and More Expensive for those Dark, Nefarious forces to navigate!
So thanks Thermoos and true Long Term holders.
Worth repeating:
Should it pan out...
The Legacies of these two women will be heralded beyond the confines of the medical world impacting every person as the Cancer market is expected to replace #1 Cardiovascular Mkt: One only needs to assemble the $'s expenses on Cancer Research and oncology $acquistions in the last few years or
ie: Harvard Business School case studies etc
CEO Linda Powers from Twice Near ASHES to the PHOENIX
And that of
UCLA's Dr Linda Liau PhD,MBA as
Chair of the Department of Neurosurgery at UCLA. Professor and Director of the UCLA Brain Tumor Program for her close to 3 decades of ground breaking work in GBM.
DIFFERENT STROKES FOR DIFFERENT FOLKS
Reverse Split : Posted too many times since 2017 the following which too many just gloss over and have INDIGESTION (like NWBO decline from >double digits to 15 cents!
The CEO MUST get shareholder & SEC approval ETC as specified here UNLIKE what many thought.
Best read is here:
https://budgeting.thenest.com/reverse-stock-split-rules-22480.html
ALSO:
UNLIKE what many presuppose.....
Despite NWBO recent ascent it does not have a five consecutive days of price advance unlike these others: Notably nGBM Approved Novocure which has been railed prominently against especially by Flipper & Sentiment and MANY others since late May 2019 in the high $40's:
NVCR hit all time high today $111; where if one shorted or even bought a Put Option: LOSE ALL your money
The other two notables on that less than 200
stocks on ALL exchanges that did have 5 up days were IMMU and INMB!
Although NWBO has had a great run recently it got close with 4 up days.. but not five.
ALL need to do their own Due Diligence to VERIFY!
Glad I always follow my sixth sense as well as tracking with what CEO Linda Powers has been all about which few give very little FOREthought to since 2014! (one needs to understand the MYRIAD of forces at play!) instead of all too often incessant repetitious backlash, whether on this, or any message board or when I am competing against Wall St titans.
Morale of above:
Venturing out of one's so called expertise, really inexperience has most definitely roilled lots of folks here financially!
DIFFERENT STROKES FOR DIFFERENT FOLKS
Floridajim et al: re
Re Investor cmz:
Re Sojourner:
SOLD a few yrs back@$7 & never looked back for the right reasons and not surprising for IMMU’s TNB this just announced:
Gilead nears deal to buy Immunomedics for more than $20 billion - WSJ
By Reuters Staff
Gilead Sciences Inc is nearing a deal to buy biopharmaceutical company Immunomedics Inc for more than $20 billion, the Wall Street Journal reported on Saturday, citing people familiar with the matter.
A deal for Immunomedics, which last month reported positive data from a late-stage study for its breast-cancer drug, could be announced Monday if not sooner, the Journal said.
Gilead and Immunomedics did not respond immediately to emailed requests from Reuters for comment.
Reporting by Ismail Shakil in Bengaluru
DIFFERENT STROKES FOR DIFFERENT FOLKS
Demystifying on a few fronts
foxhound02 Saturday, 09/19/15 12:22:11 PM
Re: afford567 post# 41132 0
Post # 41138 of 304790
Afford: (Maverick thinks Afford's ABSENTIA:IMHO fighting in legalistic quagmireS with CA evictions extended to yrend 2020 and $Mortgages accompanied by poorly timed investments)
Please cut an paste from any of my posts where I claimed that I am an expert in the "this" field. I stated that I have a Ph.D. in a non-medical area. In fact my areas of expertise are evolutionary biology and animal behavior. I have published over 20 primary journal articles in international journals and presented over 50 oral and poster presentations. I have given invited presentations at numerous universities, including Cornell. I am not a statistician, but all of my work requires extensive use of statistics of the same type used in medical research.
Maverick_1 Wednesday, 08/10/16 07:21:01 AM
Re: maverick_1 post# 69109 0
Post #
69127
of 304790
Not much equity in the property given mortgage is due[ by iclight post 67641
When is her presentation, "How to pay your mortgage with no money"? by iclight post 65875
Funny, but there is an issue in play here. Of course they could just default and let the property revert to that company LP set up to get the deal done by exwannabe post 65877
iclight Tuesday, 07/05/16 03:50:05 PM
Re: beartrap12 post# 66019
Post #
66034 of 69122 Go
Cognate has a Memphis plant. NWBO can't afford to pay for them to produce now. NWBO owns Sawston which obviously can't supply for commercialization because they might not own it after they default on the mortgage and they don't have cash to clean up the toxic issues. Kings College hasn't made a vaccine for anyone in England (Those are made at Fraunhofer) and Germany won't accept vaccines produced outside of Germany for HE anyway. That's if they were able to pay Fraunhofer per the contract even though they didn't have to produce many vaccines at all during the halt.
All of NW's money for expansion and production hasn't bought much, has it?
foxhound02 Wednesday, 07/13/16 09:14:27 PM
Re: None
Post # 66796 of 69124 Go
Anyone want to make guesses as to how long it will be until the company goes bankrupt? I give it two weeks. The company and all intellectual property will go to Cognate. The last raise should cover paying the utilities.Anyone owning shares will be wiped out. Still have 10 shares dating back 15 years (can't remember)?? It was a round-off from the reverse split forever ago.
So it's very likely Foxhound and MANY others
who go sub rosa and NOT acknowledging what I have sensed LONG AGO:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=157965760
Got to LOVE Thurs & Today's NWBO action re Market Turmoil:
Yesterday (Thurs) NWBO Went down ONLY in last 15 mins
Early Fri morning NWBO vaulted up when Mkts careened DOWN: Skeptical that data misfeed etc with "Flashcrash down to below a few pennies: On Par for Abuse of Power to Distort/Dissuade!
Nasdaq rebounded from today's depths at 10:45AM but only to recede downward during the last 30 mins !
Whereas NWBO in
Final few minutes today NWBO goes up:
CDEL on ASK 63.9 cts absorbing 20K buy
then moves to 64.0 cts on ASK
then in last few minutes CDEL gets hit at 64.0 cts and LIFTS while even OTCX AND GTSM goes to 64.0 cts Bid
At the close CDEL is Bidding 20K at 64.0 cts
Rarely, if ever do I watch NWBO like a trader.. insightful Short term only IMHO
That is how much credence the markets have in NWBO gains recently in Thurs & Fri's roller coaster markets
BTW Big Thanks to both Iwasadiver and BearTrap for their posts on OTC DAILY Short Report!
One needs an arsenal of skills which many THOUGHT they had to deal with this EPIC SAGA! since PRE 2017!
DIFFERENT STROKES FOR DIFFERENT FOLKS
Re CogDiss:
Linda P: My way or the h'way:
re DocLogic:
Biosect: Commendable expose based obviously upon the DEPTH and BREADTH of your real world experience and expertise which dovetails with my own.
Which even Larry Smith of Smith on Stocks whom I have personally met failed to perceive IMHO despite the close to 4 decades of being solely domiciled in that same market sector and space.... let alone finally realizing very belatedly and only in the last few years the Nature of Short Selling endemic to publicly traded emerging biotechs VS that of VC funded ones speaks to the below:
When one thinks they are The King of the Mountain and meanwhile The Capital Markets tell otherwise for YEARS then maybe? the mindset shifts?? Does NOT make much of even a dent based on what I've observed
So the universe is larger than what way too many has perceived has been my experience on ALL message boards PERIOD!
Thanks Biosect re:
Completed a financing of ~$8M, including ~$7M from offering at $0.32/share of new shares of ~21.8M shares with warrants averaging 21%, exercisable at $0.34 for ~5.3M shares, with an exercise period ranging from 18 to 30 months, and $1M notes, convertible at $0.345.
The company also announced to suspend, additional ~75.5M existing warrants, outstanding prior to this financing until December 15, 2020 as part of this financing.
In addition, all new warrants in this financing are suspended until December 15, 2020
DIFFERENT STROKES FOR DIFFERENT FOLKS!
The Special Sauce That Makes Some Vaccines Work
The Special Sauce That Makes Some Vaccines Work
by Joe Palca
August 6, 2020
Andrew Caballero-Reynolds/AFP
There are many approaches to making a vaccine against COVID-19. Some use genetic material from the coronavirus, some use synthetic proteins that mimic viral proteins and some use disabled versions of the virus itself.
But before any of these approaches can generate the antibodies to the coronavirus that scientists say are essential to protecting people from getting sick, the immune system has to be primed to make those antibodies.
That's the job of something called an adjuvant.
"The definition of [an] adjuvant is something you add to enhance, in the case of immunity, the immune response," says Gregory Glenn, president of research and development at Novavax, one of the companies that has received money from Operation Warp Speed.
Vaccines essentially trick the body into making an immune response to a specific virus or bacterium, so if something dangerous comes along, the immune system will be prepared.
But before it can prompt a response to a specific virus, the immune system has to be made ready.
"When you inject a vaccine, the first immune cell that's of importance is a dendritic cell," Glenn says.
Dendritic cells are part of what's called the innate immune response.These cells will respond to anything foreign that enters the body, the coronavirus included.
"If they see something — they see a virus or bacteria — they become highly activated, and then they create a whole cascade of events," Glenn says.
That cascade leads to the production of antibodies, and it's the antibodies that will recognize the specific virus of interest.
Novavax's testing shows an adjuvant is critical to its vaccine working well. That's the case for many vaccines.
But the strange thing is that there aren't a lot of adjuvants out there.
"We only think about adjuvants when there's a dire need, such as this pandemic, for example," says Bali Pulendran, a vaccine developer at Stanford University. "Now everyone is interested in faster response and a better response and a longer-lasting response."
Pulendran says for almost a century, scientists relied on a compound called alum to act as an adjuvant. It was only in the 1990s that new adjuvants started appearing on the scene. Now there are several more options, but Pulendran says more choices are needed.
"This is a topic that needs, deserves better attention," he says.
That's a sentiment Corey Casper totally agrees with. He's the CEO of the Infectious Disease Research Institute and a proselytizer for adjuvant research. Casper says to consider what happened when the pharmaceutical company GlaxoSmithKline added a powerful adjuvant to a shingles vaccine.
"It took a vaccine that had previously existed which was about 50% effective, and it made it 97% effective," Casper says. "Not just in all people but in the hardest-to-protect people, which are the elderly, who typically make poor immune responses."
Casper says the vaccine community has underestimated the importance of adjuvants. He even has data suggesting that adjuvants alone might be capable of preventing infectious disease. That has enormous implications.
"Every time a new infection pops up, there's a race to develop a new vaccine for it," Casper says. "But what if you could give the adjuvant alone and you didn't have to develop a vaccine? That adjuvant could be stockpiled, it could be made at millions of doses, placed on the shelf, sitting there waiting for the next pandemic."
Sallie Permar, a vaccine researcher at Duke University, says there may be some validity to what Casper is proposing. She says scientists now have a better idea of how adjuvants work and how they might be able to prevent disease all by themselves.
But Permar says you have to be careful with adjuvants.
"There are some downsides to having such a strong adjuvant affect," she says
In the process of activating immune cells, adjuvants can also bring on some of the symptoms of disease, such as fever, malaise or inflammation. The GlaxoSmithKline shingles vaccine works well because of its adjuvant, but many people complain about unpleasant side effects.
One problem facing vaccine developers is the fact that many companies are reluctant to share their adjuvant technology.
"Adjuvants end up being very proprietary," says Barney Graham, deputy director at the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases. "It's kind of the secret sauce of how to make your protein vaccine work."
Academic researchers are hoping the urgency of finding a successful vaccine against COVID-19 might make companies more willing to share.
"There is a whole science awaiting us in vaccines that lies in adjuvants," Permar says.
With so much attention being paid to vaccines now, that science may not be far off.
https://www.npr.org/sections/health-shots/2020/08/06/899813217/the-special-sauce-that-makes-some-vaccines-work?sc=18&f=1001
DIFFERENT STROKES FOR DIFFERENT FOLKS!