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Dosage may be dependent on weight, interactions with other drugs someone might be taking (for example, statins, which are known to have caused cognitive impairment in some people) or other illnesses like kidney or liver problems, diabetes, etc.
Yes, it would be wonderful to simplify things by saying to a caregiver, "Give the patient one of these pills every morning," or whatever the dosage interval is. But if some caregiver has to give someone a dose of 2-73 and a dose of donepazil at the same time because a combination pill is not available -- believe me, they will do it.
I view the combo drug as a convenience but not a necessity for 2-73 approval.
There is one other possibility: sometimes other diseases can masquerade as Alzheimers. Some researchers believe that "Alz" is a cluster of several diseases which manifest with the same symptoms. It's possible that the 2 non-responders may not actually have the form of Alz that the drug works on -- or perhaps they just aren't getting the right dose yet. What works for one person may not work for another. If 2-73 ends up working for "only" 10 of every 12 patients, that's 10 more than are helped by the other approved drugs.
ip_man, re your AXON short (EXCELLENT work, btw) -- I'm holding my Feb. puts on the assumption AXON will be at or close to zero then….. lol
Re support at around 3.00: a friend had a bid in at 3.02 for the last 45 minutes of the trading day but did not get filled, despite others being filled there and at 3.01.
So yes, there were buyers there -- but market makers playing games to get them to up their bid did not work, in at least one case.
There was a long period of time when you could have bought JA*Z for 20 cents or at least under a buck, and then in a couple of years it was at 175. There are several others like that which have been mentioned here.
Someday people we be amazed when we tell them we bought at .31. Or, even at 3.00
Well, you would know more than we do about how deep the shorts' pockets are.
You're lucky. I bought at 3.07. Fortunately I bought more -- a LOT more -- from .20-44
Funny to see people who professed to be so bearish on this stock, now saying we go to the moon.
Some of us have pretty good memories even without 2-73.
I will be buying more when I think that the stops have been run at some point today, in preparation for the big move up that will come as soon as people have obtained their cheap shares from the suckers who sell now based on bear droppings.
winnail you are absolutely right. Some of us acknowledge when we are wrong, others try to pretend they were right even when proven wrong. Thanks for correcting the misinformation.
Bears desperate to shake out newbies so they can buy cheap. I don't think we long-term holders are fooled.
Excellent summary. I will be adding even more if the stop-running attempt succeeds in moving this down more. I am not concerned about the ability of this company to move the science forward. Kevetrin or Brilacidin alone would be worth more than the current market cap. Think of having both of those, and also Prurisol -- this is an absurd valuation here.
Thanks for correcting that misinformation. The weekend's and today's bear droppings indicate desperation to buy the stock cheap before the next news.
If he wrote an article for an academic journal read by dozens of people at most, he would be ostracized for KNOWINGLY publishing incorrect information. Yet this guy writes an article read by hundreds or thousands, and feels no responsibility for accuracy of his data.
When the CEO of a company says "there is no patent problem" repeatedly, after being asked rudely many times about it, it is dishonest to focus on those imaginary problems. A responsible journalist would lead with something like:
"The CEO has denied repeatedly that there are any patent problems, and is confident that Anavex owns all necessary rights. However I think that there is a possibility that these problems might exist…" and then detail the rationale for disbelieving the CEO and presenting whatever purported proof there supposedly is.
Don't worry, vip1999, you didn't miss anything important. Just the usual bear droppings, food fights, and wheel spinning.
The premise seems to be: a cancer cure hasn't happened before, so it can't ever happen.
LOL
I remember a prominent scientist telling me that there would never be a cure for AIDS and that any treatments would not help significantly because there were no good ways to attack retroviruses. Um…… fast forward a decade or so, maybe not a cure, but a functional cure that offers many years of good quality life. THAT prediction was wrong, wasn't it?
Just caught up on today's bear droppings. Unbelievable the desperation some are exhibiting, trying to trash the stock by mis-stating things, raising false issues, etc.
This bodes well for next week. Someone is desperate to buy stock at a cheaper price, or cover shorts.
I hope we get a press release Monday that puts all this nonsense to rest, but even if we don't, I have no doubts that we have very promising results on Kevetrin and Brilacidin, and success with either one would make this a blockbuster like
http://bigcharts.marketwatch.com/quickchart/quickchart.asp?symb=jazz&insttype=&freq=2&show=&time=20
By the way, anyone who believes that there were tons of 100 share lots sitting there Friday because so many small investors were so anxious to sell their entire 100 share position (all my purchases Friday were listed as separate 100 share lots -- and same thing happened to a friend who bought a rather large chunk) -- well, perhaps you would like to buy some of my lovely real estate on Mars? This stock IS being manipulated.
Here's the classic for ya -- catastrophic downtrend, snooze at 20 cents…. and then in 3 years goes from 20 cents to 175.00
http://bigcharts.marketwatch.com/quickchart/quickchart.asp?symb=jazz&insttype=&freq=2&show=&time=20
All those people who bought at the IPO and then cursed as they saw their investment go almost to zero, then were richly rewarded.
Sometimes even though you know you shouldn't, you get emotional feelings toward a stock. I just hate that one -- seeing Wall Street insiders perpetrate and scam and enrich themselves while giving these poor victims false hope -- ugh.
I must say, the best thing about AVXL is thinking that we might be investing in something that literally changes the world for these patients and their families.
My point is that it is poor scholarship indeed to fail to revise an article before publication to include new information you have obtained.
If it is done sheerly out of laziness, that's even worse.
Do you think you would get an A on your 11th grade English paper if you did such a thing?
So true -- "it really does not matter here"
Very tiresome. I'll see you guys Sunday, when I start assembling statistics for my proprietary but obvious indicator.
Bogus statistic. We all know it. Please stop. People have posted information that illustrated very well why that statistic is both misleading and useless.
It amazes me how many people think that, in this day of ambulance-chaser, I mean supposed "shareholder" lawsuits, someone would make a material statement that is not true. If patients did NOT request the extension, do you think AVXL is going to send thugs to their house every day and force a pill down their throats?
Shareholder lawsuit; fraud; criminal and civil penalties. THOSE are the words that strike fear in the hearts of CEOs. No one is going to say that the patients asked to continue if they did NOT ask to continue.
Don't mean to be jumping down your throat, Dr.No, I just have have it with people being so paranoid about whether to believe a material statement made by a professional manager, on this and another board I post on.
No reverse split. The CEO has stated repeatedly there will NOT BE A REVERSE SPLIT.
This is a non-issue. There is not going to be a reverse split.
No reverse split.
No. No. No. No reverse split.
See how annoying it is when I keep saying the same thing over and over again? So please don't annoy those of us who believe the CEO when he says that he won't do a reverse split. If you don't believe the CEO when he makes a statement like that, you should not be in this stock.
His article on AXON was very good -- more focused and much better edited. Perhaps the final version will be of that caliber for AVXL.
Of course I think his AXON article was very good because it agrees with my opinion LOL !
Thanks for making him aware of AVXL. This could be a turning point in getting the word out to small investors. May bring it to the attention of some whales, too.
The supposed quotes from the article that were posted before were not solely positive. If you have access to the "real" article, then yes it is positive. Yes, he would be a fool to write negatively about a stock he has just bought -- but sometimes people do not understand how others will interpret their words, and what seems crystal clear to them is NOT so clear to others. For example, one need look no further than the now-departed CEO of NVGN, who single-handedly managed to tank a promising stock by talking to fund managers on his roadshow tour of the U.S. -- evidently he did not explain the company well (and having read some of his writings, I can see why they canned him -- he buried important news in the middle of his writing, and didn't explain it clearly).
Thanks, BobStocks. That certainly changes things. The excerpts that were posted were somewhat negative in the sense that talking about what he now seems to say is a non-issue did cast a negative pallor on the stock.
As dumb as it seems, Seeking Alpha DOES move the price of these kinds of stocks since they are primarily traded by small fry. If the article looks generally positive (as the title would indicate), I would expect this to at least stabilize the stock at this level, and probably spike it upwards.
I know that today's interview and tomorrow's article are not the same. Perhaps you missed the post in which someone posted excerpts from the upcoming article.
I'm not worried about this stock. However I think there might be a sell-off of some sort on Monday. Long term investors will be glad they have this.
Furthermore, ANY journalist knows that you NEVER publish an article with outdated information. After that interview, a responsible writer would have updated the article, instead of submitting it as is and then throwing a few caveats in (oh by the way everything I just wrote is contradicted by the CEO -- but what does HE know?)
I have been wondering whether the author hammering on the fake patent issue and talking about how the share price was supposedly 50 cents was actually a ploy to scare people. He can say, "But at the end of the article I SAID I was buying the stock!"
Yes, I find it odd that the author wouldn't revise his article on the basis of that interview.
NO ONE is going to take a chance of criminal and humongous civil penalties. Just think of the shareholder lawsuit if the CEO said "no patent problem" and then there WAS one.
You don't need to be a lawyer to know that a CEO who misstates information like that is looking at criminal charges and civil penalties.
He would NEVER say that if it were not true.
It's been amusing to see things like a trade at 3.10, immediately followed by a "trade" of 100 shares at 1.08. Snapshot of this moment: last trade 3.08, bid 3.10, ask 3.14. LOL !
Exactly right. (eom)
You gave your account a little blue pill? I didn't know that would work!
And it was at 3-4 4 years ago. I think that's something that has hurt the stock -- people who were burned buying it as high as 5 don't want to touch it again.
Fortunately that is a small category.
Silly for this to be trading at the same price as 2 years ago, when there were no human trials.
If you do an imaginary reverse split, 10 becomes 1, you will see that these tiny increments actually are meaningful, they're like a penny on a higher priced stock.
If you're buying 20 or 30 thousand shares at a time it becomes slightly meaningful, although I put this in the category of penny wise, pound foolish -- literally.
Had trouble getting a fill this morning even though I was in at the ask -- finally got frustrated, put order in for .65. Boom! filled at .65. Now look
Volume today is illuminating. flatline flatline flatline SPIKE flatline SPIKE etc
LOL
Strong hands just waiting.
Yes, those of you who are around tomorrow morning should be prepared with "comments" to post about how the patent issue is a NON issue. I have to work so can't do it myself.
Oh, so that was YOU on the 50k lot, sorry I guess I was wrong about the short covering.
LOL
Short covering.
I bought some at 3.13 earlier this morning. Was filled with multiple 100 share lots.
[sarcasm] I am sure that there are MANY individual investors who buy 100 shares of a $3 stock and then trade it back and forth. The commission cost of, say, 4.95 wouldn't affect their profit at all.[/sarcasm]