Just trying to de-code PK's PR. It's never been easy.

You also wrote to read the 8K very carefully.

The questions I raised just jumped off the page.

Has anyone been able to find out real details about Worldwide's history?

Common has no voting rights. It's meaningless to anyone wanting to own 49% of the company unless it's just speculative.

That's why the shares they are going to acquire are a different class.

The number of R/S's only proves it's in the cards to happen again.

The fact that we've witnessed what appears to have been a tremendous amount of newly minted shares since the last split and the gag put on the TA, combined with several current board members thought that the next R/S may come before September, all leads me to conclude that Worldwide has way more info than we do and is privy to what is imminent. The R/S is or is not happening. The loan repayment may be timed to happen after it happens.

Adeona Pharmaceuticals Looks Stronger After Positive Findings
Seeking Alpha
by: M. E. Garza June 5, 2011

Shares of Adeona Pharmaceuticals, Inc. (AEN) jumped as high as $1.08 before closing up (+16.22%) at $.93 on Thursday after the a developer of innovative medicines for serious central nervous system announced positive findings based on further analyses from the clinical study evaluating reaZin-- its product candidate for the dietary management of zinc deficiency associated with Alzheimer's-- along with near-term plans for its Alzheimer's disease program.

We first told our readers about Adeona's diverse clinical program in mid December of 2010 when the stock was trading at $.71. The stock went on a nice run then hit a high of $2.13 before the company announced a relatively small financing in April (the second of two which took place in Q1 2011). One perplexing drop occurred despite the fact that Adeona had reported positive results from a clinical study that met both it's primary outcome-and reported favorable secondary outcomes.

Thursday's news appears to have finally bucked the trend. Whether the upbeat sentiment actually takes hold beyond today's pop will depend greatly on whether the company can continue execute and make the investment community aware of their full value proposition. Adeona Pharmaceuticals has five drugs in various stages of development and we've been told that the management team is hoping to form another corporate partnership or two this year.
Adeona Pharmaceuticals is developing innovative medicines for the treatment of serious Central Nervous System (CNS) diseases. Their primary strategy is to license product candidates that have demonstrated a certain level of clinical efficacy and develop them to a stage that results in a significant commercial collaboration – basically this means they develop their product candidates to attract large pharmaceutical partners with deep pockets.

We feel Adeona continues to be a low-risk, investment candidate given their robust pipeline that includes product candidates in spaces that represent some big markets and unmet needs: a prescription medical food for Alzheimer’s disease, and four drugs for multiple sclerosis, fibromyalgia, age-related macular degeneration and rheumatoid arthritis.

After reviewing the statistical analysis with the Company's scientific advisors, Adeona intends to conduct another Alzheimer's disease clinical study to evaluate its proprietary zinc-based tablet in patients age 70 and over. In parallel, Adeona intends to make reaZin commercially available as a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease.

"The biological availability of zinc is impaired in Alzheimer's disease as evidenced by significantly lower plasma zinc levels and deficiencies of neuronal zinc activities, each of which are further exacerbated with age. The recent clinical study of reaZin showed that the oral treatment is well-tolerated, and there are even trends to benefits in cognitive outcomes over the study period in several readouts. Based on the consistencies in these trends, the prevalence of abnormally low plasma zinc levels in the elderly, and the established detrimental effects of chronic zinc deficiency on cognition, I think it is very reasonable to test for the ability of reaZin to ameliorate cognitive decline in a larger-scale clinical trial," said Ashley I. Bush, M.D., Ph.D., Head of the Oxidation Disorders Laboratory for the Mental Health Research Institute, University of Melbourne and Adeona Scientific Advisory Board member.

"It is well documented that zinc deficiency increases as we age, and we as well as other clinical groups have shown that Alzheimer's patients are more zinc deficient in comparison to age-matched control patients. These observations support our belief that the older an Alzheimer's patient is, the more zinc depleted that patient is, and therefore, it is likely that patient will receive greater cognitive benefit when managed with our proprietary zinc-based tablet," said George J. Brewer, M.D., Senior Vice President of Adeona. "As we are currently witnessing an epidemic of Alzheimer's disease, such that well over 10 million Americans are affected, we are very excited to begin a larger clinical study intended to further demonstrate that reaZin is effective in preventing or slowing the loss of cognition in older Alzheimer's patients and therefore help stem the tide of this epidemic."

Our opinion is that Adeona continues to have great potential and some of those programs look quite likely move into a commercial deal similar to the $17.5 million deal they locked up earlier with Swedish drug maker Meda. Once again it appears that their depressed stock price hassn’t reflected the progress they are making in the clinic and at their laboratory. Still, it's not going to happen overnight. Traders looking for a quick trade need not apply.

Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.

Adeona Pharmaceuticals Looks Stronger After Positive Findings
Seeking Alpha
by: M. E. Garza June 5, 2011

Shares of Adeona Pharmaceuticals, Inc. (AEN) jumped as high as $1.08 before closing up (+16.22%) at $.93 on Thursday after the a developer of innovative medicines for serious central nervous system announced positive findings based on further analyses from the clinical study evaluating reaZin-- its product candidate for the dietary management of zinc deficiency associated with Alzheimer's-- along with near-term plans for its Alzheimer's disease program.

We first told our readers about Adeona's diverse clinical program in mid December of 2010 when the stock was trading at $.71. The stock went on a nice run then hit a high of $2.13 before the company announced a relatively small financing in April (the second of two which took place in Q1 2011). One perplexing drop occurred despite the fact that Adeona had reported positive results from a clinical study that met both it's primary outcome-and reported favorable secondary outcomes.

Thursday's news appears to have finally bucked the trend. Whether the upbeat sentiment actually takes hold beyond today's pop will depend greatly on whether the company can continue execute and make the investment community aware of their full value proposition. Adeona Pharmaceuticals has five drugs in various stages of development and we've been told that the management team is hoping to form another corporate partnership or two this year.
Adeona Pharmaceuticals is developing innovative medicines for the treatment of serious Central Nervous System (CNS) diseases. Their primary strategy is to license product candidates that have demonstrated a certain level of clinical efficacy and develop them to a stage that results in a significant commercial collaboration – basically this means they develop their product candidates to attract large pharmaceutical partners with deep pockets.

We feel Adeona continues to be a low-risk, investment candidate given their robust pipeline that includes product candidates in spaces that represent some big markets and unmet needs: a prescription medical food for Alzheimer’s disease, and four drugs for multiple sclerosis, fibromyalgia, age-related macular degeneration and rheumatoid arthritis.

After reviewing the statistical analysis with the Company's scientific advisors, Adeona intends to conduct another Alzheimer's disease clinical study to evaluate its proprietary zinc-based tablet in patients age 70 and over. In parallel, Adeona intends to make reaZin commercially available as a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease.

"The biological availability of zinc is impaired in Alzheimer's disease as evidenced by significantly lower plasma zinc levels and deficiencies of neuronal zinc activities, each of which are further exacerbated with age. The recent clinical study of reaZin showed that the oral treatment is well-tolerated, and there are even trends to benefits in cognitive outcomes over the study period in several readouts. Based on the consistencies in these trends, the prevalence of abnormally low plasma zinc levels in the elderly, and the established detrimental effects of chronic zinc deficiency on cognition, I think it is very reasonable to test for the ability of reaZin to ameliorate cognitive decline in a larger-scale clinical trial," said Ashley I. Bush, M.D., Ph.D., Head of the Oxidation Disorders Laboratory for the Mental Health Research Institute, University of Melbourne and Adeona Scientific Advisory Board member.

"It is well documented that zinc deficiency increases as we age, and we as well as other clinical groups have shown that Alzheimer's patients are more zinc deficient in comparison to age-matched control patients. These observations support our belief that the older an Alzheimer's patient is, the more zinc depleted that patient is, and therefore, it is likely that patient will receive greater cognitive benefit when managed with our proprietary zinc-based tablet," said George J. Brewer, M.D., Senior Vice President of Adeona. "As we are currently witnessing an epidemic of Alzheimer's disease, such that well over 10 million Americans are affected, we are very excited to begin a larger clinical study intended to further demonstrate that reaZin is effective in preventing or slowing the loss of cognition in older Alzheimer's patients and therefore help stem the tide of this epidemic."

Our opinion is that Adeona continues to have great potential and some of those programs look quite likely move into a commercial deal similar to the $17.5 million deal they locked up earlier with Swedish drug maker Meda. Once again it appears that their depressed stock price hassn’t reflected the progress they are making in the clinic and at their laboratory. Still, it's not going to happen overnight. Traders looking for a quick trade need not apply.

Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.

Adeona Pharmaceuticals Looks Stronger After Positive Findings
Seeking Alpha
by: M. E. Garza June 5, 2011

Shares of Adeona Pharmaceuticals, Inc. (AEN) jumped as high as $1.08 before closing up (+16.22%) at $.93 on Thursday after the a developer of innovative medicines for serious central nervous system announced positive findings based on further analyses from the clinical study evaluating reaZin-- its product candidate for the dietary management of zinc deficiency associated with Alzheimer's-- along with near-term plans for its Alzheimer's disease program.

We first told our readers about Adeona's diverse clinical program in mid December of 2010 when the stock was trading at $.71. The stock went on a nice run then hit a high of $2.13 before the company announced a relatively small financing in April (the second of two which took place in Q1 2011). One perplexing drop occurred despite the fact that Adeona had reported positive results from a clinical study that met both it's primary outcome-and reported favorable secondary outcomes.

Thursday's news appears to have finally bucked the trend. Whether the upbeat sentiment actually takes hold beyond today's pop will depend greatly on whether the company can continue execute and make the investment community aware of their full value proposition. Adeona Pharmaceuticals has five drugs in various stages of development and we've been told that the management team is hoping to form another corporate partnership or two this year.
Adeona Pharmaceuticals is developing innovative medicines for the treatment of serious Central Nervous System (CNS) diseases. Their primary strategy is to license product candidates that have demonstrated a certain level of clinical efficacy and develop them to a stage that results in a significant commercial collaboration – basically this means they develop their product candidates to attract large pharmaceutical partners with deep pockets.

We feel Adeona continues to be a low-risk, investment candidate given their robust pipeline that includes product candidates in spaces that represent some big markets and unmet needs: a prescription medical food for Alzheimer’s disease, and four drugs for multiple sclerosis, fibromyalgia, age-related macular degeneration and rheumatoid arthritis.

After reviewing the statistical analysis with the Company's scientific advisors, Adeona intends to conduct another Alzheimer's disease clinical study to evaluate its proprietary zinc-based tablet in patients age 70 and over. In parallel, Adeona intends to make reaZin commercially available as a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease.

"The biological availability of zinc is impaired in Alzheimer's disease as evidenced by significantly lower plasma zinc levels and deficiencies of neuronal zinc activities, each of which are further exacerbated with age. The recent clinical study of reaZin showed that the oral treatment is well-tolerated, and there are even trends to benefits in cognitive outcomes over the study period in several readouts. Based on the consistencies in these trends, the prevalence of abnormally low plasma zinc levels in the elderly, and the established detrimental effects of chronic zinc deficiency on cognition, I think it is very reasonable to test for the ability of reaZin to ameliorate cognitive decline in a larger-scale clinical trial," said Ashley I. Bush, M.D., Ph.D., Head of the Oxidation Disorders Laboratory for the Mental Health Research Institute, University of Melbourne and Adeona Scientific Advisory Board member.

"It is well documented that zinc deficiency increases as we age, and we as well as other clinical groups have shown that Alzheimer's patients are more zinc deficient in comparison to age-matched control patients. These observations support our belief that the older an Alzheimer's patient is, the more zinc depleted that patient is, and therefore, it is likely that patient will receive greater cognitive benefit when managed with our proprietary zinc-based tablet," said George J. Brewer, M.D., Senior Vice President of Adeona. "As we are currently witnessing an epidemic of Alzheimer's disease, such that well over 10 million Americans are affected, we are very excited to begin a larger clinical study intended to further demonstrate that reaZin is effective in preventing or slowing the loss of cognition in older Alzheimer's patients and therefore help stem the tide of this epidemic."

Our opinion is that Adeona continues to have great potential and some of those programs look quite likely move into a commercial deal similar to the $17.5 million deal they locked up earlier with Swedish drug maker Meda. Once again it appears that their depressed stock price hassn’t reflected the progress they are making in the clinic and at their laboratory. Still, it's not going to happen overnight. Traders looking for a quick trade need not apply.

Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.

Adeona Pharmaceuticals Looks Stronger After Positive Findings
Seeking Alpha
by: M. E. Garza June 5, 2011

Shares of Adeona Pharmaceuticals, Inc. (AEN) jumped as high as $1.08 before closing up (+16.22%) at $.93 on Thursday after the a developer of innovative medicines for serious central nervous system announced positive findings based on further analyses from the clinical study evaluating reaZin-- its product candidate for the dietary management of zinc deficiency associated with Alzheimer's-- along with near-term plans for its Alzheimer's disease program.

We first told our readers about Adeona's diverse clinical program in mid December of 2010 when the stock was trading at $.71. The stock went on a nice run then hit a high of $2.13 before the company announced a relatively small financing in April (the second of two which took place in Q1 2011). One perplexing drop occurred despite the fact that Adeona had reported positive results from a clinical study that met both it's primary outcome-and reported favorable secondary outcomes.

Thursday's news appears to have finally bucked the trend. Whether the upbeat sentiment actually takes hold beyond today's pop will depend greatly on whether the company can continue execute and make the investment community aware of their full value proposition. Adeona Pharmaceuticals has five drugs in various stages of development and we've been told that the management team is hoping to form another corporate partnership or two this year.
Adeona Pharmaceuticals is developing innovative medicines for the treatment of serious Central Nervous System (CNS) diseases. Their primary strategy is to license product candidates that have demonstrated a certain level of clinical efficacy and develop them to a stage that results in a significant commercial collaboration – basically this means they develop their product candidates to attract large pharmaceutical partners with deep pockets.

We feel Adeona continues to be a low-risk, investment candidate given their robust pipeline that includes product candidates in spaces that represent some big markets and unmet needs: a prescription medical food for Alzheimer’s disease, and four drugs for multiple sclerosis, fibromyalgia, age-related macular degeneration and rheumatoid arthritis.

After reviewing the statistical analysis with the Company's scientific advisors, Adeona intends to conduct another Alzheimer's disease clinical study to evaluate its proprietary zinc-based tablet in patients age 70 and over. In parallel, Adeona intends to make reaZin commercially available as a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease.

"The biological availability of zinc is impaired in Alzheimer's disease as evidenced by significantly lower plasma zinc levels and deficiencies of neuronal zinc activities, each of which are further exacerbated with age. The recent clinical study of reaZin showed that the oral treatment is well-tolerated, and there are even trends to benefits in cognitive outcomes over the study period in several readouts. Based on the consistencies in these trends, the prevalence of abnormally low plasma zinc levels in the elderly, and the established detrimental effects of chronic zinc deficiency on cognition, I think it is very reasonable to test for the ability of reaZin to ameliorate cognitive decline in a larger-scale clinical trial," said Ashley I. Bush, M.D., Ph.D., Head of the Oxidation Disorders Laboratory for the Mental Health Research Institute, University of Melbourne and Adeona Scientific Advisory Board member.

"It is well documented that zinc deficiency increases as we age, and we as well as other clinical groups have shown that Alzheimer's patients are more zinc deficient in comparison to age-matched control patients. These observations support our belief that the older an Alzheimer's patient is, the more zinc depleted that patient is, and therefore, it is likely that patient will receive greater cognitive benefit when managed with our proprietary zinc-based tablet," said George J. Brewer, M.D., Senior Vice President of Adeona. "As we are currently witnessing an epidemic of Alzheimer's disease, such that well over 10 million Americans are affected, we are very excited to begin a larger clinical study intended to further demonstrate that reaZin is effective in preventing or slowing the loss of cognition in older Alzheimer's patients and therefore help stem the tide of this epidemic."

Our opinion is that Adeona continues to have great potential and some of those programs look quite likely move into a commercial deal similar to the $17.5 million deal they locked up earlier with Swedish drug maker Meda. Once again it appears that their depressed stock price hassn’t reflected the progress they are making in the clinic and at their laboratory. Still, it's not going to happen overnight. Traders looking for a quick trade need not apply.

Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.

Something smells fishy.

Has anyone figured out what class of shares Worldwide may acquire to reach a maximum of 49% of the company?

What does the 125,000,000 common share purchase have to do with "ownership" if common has no voting rights? Is that just speculative on their part? They don't have to purchase any, right? Or maybe they won't purchase them until after the next R/S?

Does Worldwide have a distribution network and current sales, or have they been signing deals to distribute other companies products, and now they are signing this deal with DKAM to use DKAM's distribution network?

Some of their cash contribution may come from product sales proceeds, of which cost of goods has to be deducted, right? Wouldn't that mean that they have to sell a tremendous amount of product for "profit" to reach "no less than $1.5 million"?

Considering the current prime rate at 3.25%, the 8% isn't usary, but it's only short term. $250,000 is significant thought, and that's very good.

"The Loan will mature on November 20, 2011 and will bear interest at 8% annually, payable monthly in arrears commencing on July 1, 2011."

Sounds like a "bridge" loan to me. What's the purpose of it? Maybe it's that in the short term it might enable DKAM to produce a lot more Rheingold?


The Worldwide deal needs to shake out so we see how it's going to effect DKAM, and the shareholders. On the surface it looks like a much need cash infusion, but it also smells a little fishy to me. There are so many questions that need answers.

Any speculation?

They just killed my leverage.

"It's obvious that DKAM is making some headway" is today's truth. They are expanding, and a new insider has gotten involved. That has to be better than the status quo we lived with before. They just earned "more time" to make something happen.

Their PR's aren't all lies; I don't believe even a little bit. What we do know is their PR's are all meant to pump (and then dump).

Lots of companies release news as a course of doing business without a pump in mind. Many give more details too.

DKAM PR's just aren't as all inclusive of information you want to know.

When they add distributors, they are adding sales. We're not seeing numbers, but they don't have to reveal them. Granted, we don't want to guess, we want to know.

If I thought Worldwide looked like a straight company I would be ecstatic. But that also may be why the stock isn't over 1¢ this morning. They may be as shady as PK.

The R/S seems pretty inevitable. That doesn't mean between now and then traders can't make real $'s.

Just get it done before the next financial release.

Some of the transaction's shares very well may be coming from PK and others, however you and I assume they are being freshly minted. If so, Worldwide Beverage Imports, LLC knows what's going on too.

I hope the end game here is not a R/S to get in on PK's money machine. The despiration PK might be feeling is it couldn't go on for ever, so 1/2 is better than nothing. That is a possibility.

Hopefully, Worldwide is a serious investor. But there is no telling about that ... http://www.wbillc.com/

Can't really make out what's going on, but it may be why it's not in pennyland already today.
http://www.encorebrands.com/news/encore-brands-inc-signs-agreement-with-worldwide-beverage-imports-for-premium-tequila-brands/


http://www.corporationwiki.com/California/Camarillo/worldwide-beverage-imports-llc/45503580.aspx


Look at the google links to the company.

I was talking about this happening over a year ago. I deep pocket coming in, taking board seats, and putting PK on a leash. Seems like that is happening, plus it may be a set up to a future take over of the company.

If the shares were issued by the company, a R/S has to be in the making.

However, I like seeing the cash or cash equivalents being put into the company.

Where are the 125,000,000 shares coming from?

Are you going to the www.bigapplebbq.org/ this w/e? Wish I could, but two trips in two weeks is too much.


I won't be back in the area until August when I'll be heading out to Jordan's Lobster Farm in Island Park for monsterous lobsters. I'll eat them on the patio and hopefully find some Rheingold nearby.

Get with proper BBQ'ing ... my sirloins have been marinading for over 24 hours.

The Rheingold will wash them down and leave a nice finish.


BTW, I was bummed last w/e when I didn't see Rhiengold in any of the Times Square area stores. What a great tourist area for exposure.

Watch for sub 3¢ next week and sub penny this summer.

Some people are finally starting to realize, SFIO can't make money for years to come even if their products are a hit.

Rheingold is a great "session beer". I goes down reeeeeaaalll easy.

I've popped a few while enjoying that special time of time of day when the angle of the sun's rays dip nearer to the horizon. We're getting ready for some tasty sirloins.

The only thing I would prefer is to find Rheingold bottles instead of cans. Thanks for the pic.

As you said, people are watching this because AEN gets the federal grants, but I also think because of the three private investors who bought a few million shares in private sales a couple of months ago. They had real conviction and much more insider info than you and I have.

I am one of the accumulators

2 very interesting "buys" ... 11,250 and 15,000 ... and only 1 300 share sell

But geeeezzzzz ... only 8 trades today.

202 transactions and more than $120,000 traded hands.

AEN looks great after not giving back any ground today after a murderous day/week.

We all know it's been a blood-bath in the market this week yet AEN held strong. I think we really have found AEN's bottom.

Pricewise, Rheingold costs less locally than an equivalent 30 pack of ANY Bud or Miller product.

If an advertisement appeared saying that, sales would grow organically.

That would be doubly exciting ... an advertisement!!!! ... and organic growth at individual locations.

That would mean so much to the share price.

Sub penny here we go. No matter how exciting the action has been and how much some traders have made, SFIO still has the same management and has to eventually report sales figures. Prepare to be disappointed.

I pay $8.49 for a 12-pack of Rheingold.

I definately agree with your thoughts, especially regarding reaZin since there is so much top-of-the-mind Alzheimer's awareness. It's also going to happen soon; not today or tomorrow, but soon enough.

The high volume of small trades is also very encouraging. 100 share buyers aren't looking to flip on a 25¢ gain. They're confident "longs".

We're seeing good price support in the face of an ugly market. When Trimesta (estriol) moves to the Phase 3 trial I expect we'll see $2+ on the exciting news.

I'll be in NYC's mid-town and Times Square area this w/e. Spiced between why I am there will be several stops in pubs and small bodegas looking for Rheingold.

Since DKAM has done a pitiful job keeping the "where to by" section of the web site current, hopefully I will see it, and be pleasantly surprised.

It looks like diluting shares cannot find a home today.

There is no reason to artificially push the price over $5, and leave the outstanding shares at less than 8,000,000.

It won't trade, and it won't add value to management.

What they need to do is push revenue over $50,000,000 and start showing a profit, which is likely during the next 12 months as the tests presently underway lead to product purchases.

That will lead to more tests and sales.

As that happens, management will find it beneficial to start doing share buy-backs. That's where I see the future of CUGI.

AEN is up 33% this morning.



The board of directors and management resumes are great too.




Adeona Announces Positive Alzheimer's Subgroup Analysis that Supports Additional Clinical Study of Proprietary Zinc-Based Therapy
PR Newswire
Posted 9:00 AM 06/02/11


ANN ARBOR, Mich., June 2, 2011 /PRNewswire/ -- Adeona Pharmaceuticals, Inc. (NYSE Amex: AEN), a developer of innovative medicines for serious central nervous system diseases, announced today positive findings based on further analyses from the clinical study evaluating reaZin along with near-term plans for its Alzheimer's disease program. After reviewing the statistical analysis with the Company's scientific advisors, Adeona intends to conduct another Alzheimer's disease clinical study to evaluate its proprietary zinc-based tablet in patients age 70 and over. In parallel, Adeona intends to make reaZin commercially available as a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease.

After presenting the top-line results in April from the clinical study evaluating reaZin that demonstrated, on average, that the cognitive function (as measured by three standardized cognitive tests) of the patients managed with reaZin remained relatively stable over six months, while the placebo group showed deterioration, Adeona conducted further analyses to determine if certain subgroups in the patient sample benefitted from reaZin more than others.

After analyzing a number of independent variables associated with the patients enrolled in the clinical study on a post-hoc basis, the strongest relationship was found to be between age and cognitive outcomes. Patients in the study ranged from 52 to 86 years of age. Patients in the placebo group, on average, showed age-related cognitive decline – the older the patient, the greater the rate of cognitive decline. In contrast, patients in the reaZin treatment group, on average, showed cognitive stabilization, no matter what their age. Therefore, the older the reaZin treatment patient, the greater the amount of cognitive benefit compared to the placebo patients of the same age.

These observations were supported by an age-related subgroup analysis that showed dosing-compliant patients age 70 and over (approximately the oldest three quartiles of the patients evaluable at the end of the study) demonstrated statistically significant improvements in two of the three cognitive scoring measurements in the reaZin treatment group compared to the placebo group. As presented below, in this subgroup, two of the three standard cognitive measures reached statistical significance (p < 0.05) as determined by the p-values (the average changes in cognitive scores from baseline to 6 months in the treatment group compared to the placebo group). The p-values were as follows:

?ADAS-Cog - Alzheimer's Disease Assessment Scale - Cognitive Subscale p-value: 0.037
?CDR-SOB - Clinical Dementia Rating Scale - Sum of Boxes p-value: 0.032
?MMSE - Mini Mental State Examination p-value: 0.067


Based upon the apparent cognitive benefit observed in these older patients who were managed with reaZin in comparison to patients who received the matching placebo, Adeona is preparing a larger clinical study protocol to evaluate patients diagnosed with mild to moderate Alzheimer's disease who are age 70 and over. It is anticipated that the clinical study will enroll over 100 patients and that the evaluation period will be at least 12 months. The intention is to develop the Company's proprietary zinc-based tablet as a drug (in parallel with making reaZin available as a prescription medical food) and to conduct this new clinical study under an Investigational New Drug (IND) application to be filed with the Food & Drug Administration (FDA).

"The biological availability of zinc is impaired in Alzheimer's disease as evidenced by significantly lower plasma zinc levels and deficiencies of neuronal zinc activities, each of which are further exacerbated with age. The recent clinical study of reaZin showed that the oral treatment is well-tolerated, and there are even trends to benefits in cognitive outcomes over the study period in several readouts. Based on the consistencies in these trends, the prevalence of abnormally low plasma zinc levels in the elderly, and the established detrimental effects of chronic zinc deficiency on cognition, I think it is very reasonable to test for the ability of reaZin to ameliorate cognitive decline in a larger-scale clinical trial," said Ashley I. Bush, M.D., Ph.D., Head of the Oxidation Disorders Laboratory for the Mental Health Research Institute, University of Melbourne and Adeona Scientific Advisory Board member.

"It is well documented that zinc deficiency increases as we age, and we as well as other clinical groups have shown that Alzheimer's patients are more zinc deficient in comparison to age-matched control patients. These observations support our belief that the older an Alzheimer's patient is, the more zinc depleted that patient is, and therefore, it is likely that patient will receive greater cognitive benefit when managed with our proprietary zinc-based tablet," said George J. Brewer, M.D., Senior Vice President of Adeona. "As we are currently witnessing an epidemic of Alzheimer's disease, such that well over 10 million Americans are affected, we are very excited to begin a larger clinical study intended to further demonstrate that reaZin is effective in preventing or slowing the loss of cognition in older Alzheimer's patients and therefore help stem the tide of this epidemic."

Top-Line Results from the Clinical Study Evaluating reaZin

The top-line results from Adeona's clinical study evaluating reaZin for the dietary management of zinc deficiency associated with Alzheimer's disease were presented at the 63rd Annual Meeting of the American Academy of Neurology in April 2011. As prospectively hypothesized, patients administered reaZin demonstrated increased serum zinc levels and decreased serum free copper levels, resulting in statistical significance of the primary outcomes of the clinical study (p < 0.0006). The cognitive function of the placebo group, on average, declined over 6 months in comparison to patients managed with reaZin. The cognitive function trends favoring the patients managed with reaZin were observed in all three standardized cognitive tests utilized in our study and suggest that reaZin may provide an important benefit to the dietary management of zinc deficiency associated with Alzheimer's disease.

About reaZin

reaZin is a proprietary, gastroretentive, sustained release, once-daily oral tablet formulated from zinc (150 mg) and cysteine (100 mg), an amino acid with potent anti-oxidant properties. reaZin was developed by Adeona to achieve the following: 1) the convenience of a once-daily dose, 2) high oral bioavailability (the quantity or fraction of the ingested dose that is absorbed by the body) and 3) superior tolerability which provides the ability to minimize the substantial gastrointestinal side effects and limitations associated with existing oral zinc therapy.

About Adeona Pharmaceuticals, Inc.

Adeona is a pharmaceutical company developing innovative medicines for the treatment of serious central nervous system diseases. The Company's primary strategy is to license product candidates that have demonstrated a certain level of clinical efficacy and develop them to a stage that results in a significant commercial collaboration. Currently, Adeona is developing, or has partnered the development of, the following product candidates: a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease, and drugs to treat multiple sclerosis, fibromyalgia, Alzheimer's disease and age-related macular degeneration. For more information, please visit Adeona's website at www.adeonapharma.com.

This release includes forward-looking statements on Adeona's current expectations and projections about future events. In some cases forward-looking statements can be identified by terminology such as "may,""could,""potential,""positions,""continue,""expects,""anticipates,""intends,""plans,""believe,""estimates," and similar expressions. These statements are based upon current beliefs, expectations and assumptions and are subject to a number of risks and uncertainties, many of which are difficult to predict and include statements regarding the plans to move our Alzheimer's disease development program forward, our intent to conduct another clinical study in Alzheimer's disease patients age 70 and over, the use of zinc as a potential dietary management for cognitive deficits in Alzheimer's patients, the limitations inherent in post-hoc interpretations of clinical study results, the size of the Alzheimer's population, our intent to further commercialize development of reaZin as a prescription medical food, the size and evaluation time of the anticipated clinical study and the expected results of the larger clinical study with regard to the loss of cognition. The forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those set forth or implied by any forward-looking statements. Important factors that could cause actual results to differ materially from those reflected in Adeona's forward-looking statements include, among others, our failure to successfully commercialize reaZin for the management of Alzheimer's disease, the failure of reaZin to be accepted for dietary management of Alzheimer's disease, failure of future clinical studies evaluating reaZin to have favorable results, and other factors described in Adeona's report on Form 10-K for the year ended December 31, 2010 and any other filings with the SEC. The information in this release is provided only as of the date of this release, and Adeona undertakes no obligation to update any forward-looking statements contained in this release on account of new information, future events, or otherwise, except as required by law.

SOURCE Adeona Pharmaceuticals, Inc.



See full article from DailyFinance: http://srph.it/mF6Qum

AEN is up 33% this morning.



The board of directors and management resumes are great too.




Adeona Announces Positive Alzheimer's Subgroup Analysis that Supports Additional Clinical Study of Proprietary Zinc-Based Therapy
PR Newswire
Posted 9:00 AM 06/02/11


ANN ARBOR, Mich., June 2, 2011 /PRNewswire/ -- Adeona Pharmaceuticals, Inc. (NYSE Amex: AEN), a developer of innovative medicines for serious central nervous system diseases, announced today positive findings based on further analyses from the clinical study evaluating reaZin along with near-term plans for its Alzheimer's disease program. After reviewing the statistical analysis with the Company's scientific advisors, Adeona intends to conduct another Alzheimer's disease clinical study to evaluate its proprietary zinc-based tablet in patients age 70 and over. In parallel, Adeona intends to make reaZin commercially available as a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease.

After presenting the top-line results in April from the clinical study evaluating reaZin that demonstrated, on average, that the cognitive function (as measured by three standardized cognitive tests) of the patients managed with reaZin remained relatively stable over six months, while the placebo group showed deterioration, Adeona conducted further analyses to determine if certain subgroups in the patient sample benefitted from reaZin more than others.

After analyzing a number of independent variables associated with the patients enrolled in the clinical study on a post-hoc basis, the strongest relationship was found to be between age and cognitive outcomes. Patients in the study ranged from 52 to 86 years of age. Patients in the placebo group, on average, showed age-related cognitive decline – the older the patient, the greater the rate of cognitive decline. In contrast, patients in the reaZin treatment group, on average, showed cognitive stabilization, no matter what their age. Therefore, the older the reaZin treatment patient, the greater the amount of cognitive benefit compared to the placebo patients of the same age.

These observations were supported by an age-related subgroup analysis that showed dosing-compliant patients age 70 and over (approximately the oldest three quartiles of the patients evaluable at the end of the study) demonstrated statistically significant improvements in two of the three cognitive scoring measurements in the reaZin treatment group compared to the placebo group. As presented below, in this subgroup, two of the three standard cognitive measures reached statistical significance (p < 0.05) as determined by the p-values (the average changes in cognitive scores from baseline to 6 months in the treatment group compared to the placebo group). The p-values were as follows:

?ADAS-Cog - Alzheimer's Disease Assessment Scale - Cognitive Subscale p-value: 0.037
?CDR-SOB - Clinical Dementia Rating Scale - Sum of Boxes p-value: 0.032
?MMSE - Mini Mental State Examination p-value: 0.067


Based upon the apparent cognitive benefit observed in these older patients who were managed with reaZin in comparison to patients who received the matching placebo, Adeona is preparing a larger clinical study protocol to evaluate patients diagnosed with mild to moderate Alzheimer's disease who are age 70 and over. It is anticipated that the clinical study will enroll over 100 patients and that the evaluation period will be at least 12 months. The intention is to develop the Company's proprietary zinc-based tablet as a drug (in parallel with making reaZin available as a prescription medical food) and to conduct this new clinical study under an Investigational New Drug (IND) application to be filed with the Food & Drug Administration (FDA).

"The biological availability of zinc is impaired in Alzheimer's disease as evidenced by significantly lower plasma zinc levels and deficiencies of neuronal zinc activities, each of which are further exacerbated with age. The recent clinical study of reaZin showed that the oral treatment is well-tolerated, and there are even trends to benefits in cognitive outcomes over the study period in several readouts. Based on the consistencies in these trends, the prevalence of abnormally low plasma zinc levels in the elderly, and the established detrimental effects of chronic zinc deficiency on cognition, I think it is very reasonable to test for the ability of reaZin to ameliorate cognitive decline in a larger-scale clinical trial," said Ashley I. Bush, M.D., Ph.D., Head of the Oxidation Disorders Laboratory for the Mental Health Research Institute, University of Melbourne and Adeona Scientific Advisory Board member.

"It is well documented that zinc deficiency increases as we age, and we as well as other clinical groups have shown that Alzheimer's patients are more zinc deficient in comparison to age-matched control patients. These observations support our belief that the older an Alzheimer's patient is, the more zinc depleted that patient is, and therefore, it is likely that patient will receive greater cognitive benefit when managed with our proprietary zinc-based tablet," said George J. Brewer, M.D., Senior Vice President of Adeona. "As we are currently witnessing an epidemic of Alzheimer's disease, such that well over 10 million Americans are affected, we are very excited to begin a larger clinical study intended to further demonstrate that reaZin is effective in preventing or slowing the loss of cognition in older Alzheimer's patients and therefore help stem the tide of this epidemic."

Top-Line Results from the Clinical Study Evaluating reaZin

The top-line results from Adeona's clinical study evaluating reaZin for the dietary management of zinc deficiency associated with Alzheimer's disease were presented at the 63rd Annual Meeting of the American Academy of Neurology in April 2011. As prospectively hypothesized, patients administered reaZin demonstrated increased serum zinc levels and decreased serum free copper levels, resulting in statistical significance of the primary outcomes of the clinical study (p < 0.0006). The cognitive function of the placebo group, on average, declined over 6 months in comparison to patients managed with reaZin. The cognitive function trends favoring the patients managed with reaZin were observed in all three standardized cognitive tests utilized in our study and suggest that reaZin may provide an important benefit to the dietary management of zinc deficiency associated with Alzheimer's disease.

About reaZin

reaZin is a proprietary, gastroretentive, sustained release, once-daily oral tablet formulated from zinc (150 mg) and cysteine (100 mg), an amino acid with potent anti-oxidant properties. reaZin was developed by Adeona to achieve the following: 1) the convenience of a once-daily dose, 2) high oral bioavailability (the quantity or fraction of the ingested dose that is absorbed by the body) and 3) superior tolerability which provides the ability to minimize the substantial gastrointestinal side effects and limitations associated with existing oral zinc therapy.

About Adeona Pharmaceuticals, Inc.

Adeona is a pharmaceutical company developing innovative medicines for the treatment of serious central nervous system diseases. The Company's primary strategy is to license product candidates that have demonstrated a certain level of clinical efficacy and develop them to a stage that results in a significant commercial collaboration. Currently, Adeona is developing, or has partnered the development of, the following product candidates: a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease, and drugs to treat multiple sclerosis, fibromyalgia, Alzheimer's disease and age-related macular degeneration. For more information, please visit Adeona's website at www.adeonapharma.com.

This release includes forward-looking statements on Adeona's current expectations and projections about future events. In some cases forward-looking statements can be identified by terminology such as "may,""could,""potential,""positions,""continue,""expects,""anticipates,""intends,""plans,""believe,""estimates," and similar expressions. These statements are based upon current beliefs, expectations and assumptions and are subject to a number of risks and uncertainties, many of which are difficult to predict and include statements regarding the plans to move our Alzheimer's disease development program forward, our intent to conduct another clinical study in Alzheimer's disease patients age 70 and over, the use of zinc as a potential dietary management for cognitive deficits in Alzheimer's patients, the limitations inherent in post-hoc interpretations of clinical study results, the size of the Alzheimer's population, our intent to further commercialize development of reaZin as a prescription medical food, the size and evaluation time of the anticipated clinical study and the expected results of the larger clinical study with regard to the loss of cognition. The forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those set forth or implied by any forward-looking statements. Important factors that could cause actual results to differ materially from those reflected in Adeona's forward-looking statements include, among others, our failure to successfully commercialize reaZin for the management of Alzheimer's disease, the failure of reaZin to be accepted for dietary management of Alzheimer's disease, failure of future clinical studies evaluating reaZin to have favorable results, and other factors described in Adeona's report on Form 10-K for the year ended December 31, 2010 and any other filings with the SEC. The information in this release is provided only as of the date of this release, and Adeona undertakes no obligation to update any forward-looking statements contained in this release on account of new information, future events, or otherwise, except as required by law.

SOURCE Adeona Pharmaceuticals, Inc.



See full article from DailyFinance: http://srph.it/mF6Qum

AEN is up 33% this morning.



The board of directors and management resumes are great too.




Adeona Announces Positive Alzheimer's Subgroup Analysis that Supports Additional Clinical Study of Proprietary Zinc-Based Therapy
PR Newswire
Posted 9:00 AM 06/02/11


ANN ARBOR, Mich., June 2, 2011 /PRNewswire/ -- Adeona Pharmaceuticals, Inc. (NYSE Amex: AEN), a developer of innovative medicines for serious central nervous system diseases, announced today positive findings based on further analyses from the clinical study evaluating reaZin along with near-term plans for its Alzheimer's disease program. After reviewing the statistical analysis with the Company's scientific advisors, Adeona intends to conduct another Alzheimer's disease clinical study to evaluate its proprietary zinc-based tablet in patients age 70 and over. In parallel, Adeona intends to make reaZin commercially available as a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease.

After presenting the top-line results in April from the clinical study evaluating reaZin that demonstrated, on average, that the cognitive function (as measured by three standardized cognitive tests) of the patients managed with reaZin remained relatively stable over six months, while the placebo group showed deterioration, Adeona conducted further analyses to determine if certain subgroups in the patient sample benefitted from reaZin more than others.

After analyzing a number of independent variables associated with the patients enrolled in the clinical study on a post-hoc basis, the strongest relationship was found to be between age and cognitive outcomes. Patients in the study ranged from 52 to 86 years of age. Patients in the placebo group, on average, showed age-related cognitive decline – the older the patient, the greater the rate of cognitive decline. In contrast, patients in the reaZin treatment group, on average, showed cognitive stabilization, no matter what their age. Therefore, the older the reaZin treatment patient, the greater the amount of cognitive benefit compared to the placebo patients of the same age.

These observations were supported by an age-related subgroup analysis that showed dosing-compliant patients age 70 and over (approximately the oldest three quartiles of the patients evaluable at the end of the study) demonstrated statistically significant improvements in two of the three cognitive scoring measurements in the reaZin treatment group compared to the placebo group. As presented below, in this subgroup, two of the three standard cognitive measures reached statistical significance (p < 0.05) as determined by the p-values (the average changes in cognitive scores from baseline to 6 months in the treatment group compared to the placebo group). The p-values were as follows:

?ADAS-Cog - Alzheimer's Disease Assessment Scale - Cognitive Subscale p-value: 0.037
?CDR-SOB - Clinical Dementia Rating Scale - Sum of Boxes p-value: 0.032
?MMSE - Mini Mental State Examination p-value: 0.067


Based upon the apparent cognitive benefit observed in these older patients who were managed with reaZin in comparison to patients who received the matching placebo, Adeona is preparing a larger clinical study protocol to evaluate patients diagnosed with mild to moderate Alzheimer's disease who are age 70 and over. It is anticipated that the clinical study will enroll over 100 patients and that the evaluation period will be at least 12 months. The intention is to develop the Company's proprietary zinc-based tablet as a drug (in parallel with making reaZin available as a prescription medical food) and to conduct this new clinical study under an Investigational New Drug (IND) application to be filed with the Food & Drug Administration (FDA).

"The biological availability of zinc is impaired in Alzheimer's disease as evidenced by significantly lower plasma zinc levels and deficiencies of neuronal zinc activities, each of which are further exacerbated with age. The recent clinical study of reaZin showed that the oral treatment is well-tolerated, and there are even trends to benefits in cognitive outcomes over the study period in several readouts. Based on the consistencies in these trends, the prevalence of abnormally low plasma zinc levels in the elderly, and the established detrimental effects of chronic zinc deficiency on cognition, I think it is very reasonable to test for the ability of reaZin to ameliorate cognitive decline in a larger-scale clinical trial," said Ashley I. Bush, M.D., Ph.D., Head of the Oxidation Disorders Laboratory for the Mental Health Research Institute, University of Melbourne and Adeona Scientific Advisory Board member.

"It is well documented that zinc deficiency increases as we age, and we as well as other clinical groups have shown that Alzheimer's patients are more zinc deficient in comparison to age-matched control patients. These observations support our belief that the older an Alzheimer's patient is, the more zinc depleted that patient is, and therefore, it is likely that patient will receive greater cognitive benefit when managed with our proprietary zinc-based tablet," said George J. Brewer, M.D., Senior Vice President of Adeona. "As we are currently witnessing an epidemic of Alzheimer's disease, such that well over 10 million Americans are affected, we are very excited to begin a larger clinical study intended to further demonstrate that reaZin is effective in preventing or slowing the loss of cognition in older Alzheimer's patients and therefore help stem the tide of this epidemic."

Top-Line Results from the Clinical Study Evaluating reaZin

The top-line results from Adeona's clinical study evaluating reaZin for the dietary management of zinc deficiency associated with Alzheimer's disease were presented at the 63rd Annual Meeting of the American Academy of Neurology in April 2011. As prospectively hypothesized, patients administered reaZin demonstrated increased serum zinc levels and decreased serum free copper levels, resulting in statistical significance of the primary outcomes of the clinical study (p < 0.0006). The cognitive function of the placebo group, on average, declined over 6 months in comparison to patients managed with reaZin. The cognitive function trends favoring the patients managed with reaZin were observed in all three standardized cognitive tests utilized in our study and suggest that reaZin may provide an important benefit to the dietary management of zinc deficiency associated with Alzheimer's disease.

About reaZin

reaZin is a proprietary, gastroretentive, sustained release, once-daily oral tablet formulated from zinc (150 mg) and cysteine (100 mg), an amino acid with potent anti-oxidant properties. reaZin was developed by Adeona to achieve the following: 1) the convenience of a once-daily dose, 2) high oral bioavailability (the quantity or fraction of the ingested dose that is absorbed by the body) and 3) superior tolerability which provides the ability to minimize the substantial gastrointestinal side effects and limitations associated with existing oral zinc therapy.

About Adeona Pharmaceuticals, Inc.

Adeona is a pharmaceutical company developing innovative medicines for the treatment of serious central nervous system diseases. The Company's primary strategy is to license product candidates that have demonstrated a certain level of clinical efficacy and develop them to a stage that results in a significant commercial collaboration. Currently, Adeona is developing, or has partnered the development of, the following product candidates: a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease, and drugs to treat multiple sclerosis, fibromyalgia, Alzheimer's disease and age-related macular degeneration. For more information, please visit Adeona's website at www.adeonapharma.com.

This release includes forward-looking statements on Adeona's current expectations and projections about future events. In some cases forward-looking statements can be identified by terminology such as "may,""could,""potential,""positions,""continue,""expects,""anticipates,""intends,""plans,""believe,""estimates," and similar expressions. These statements are based upon current beliefs, expectations and assumptions and are subject to a number of risks and uncertainties, many of which are difficult to predict and include statements regarding the plans to move our Alzheimer's disease development program forward, our intent to conduct another clinical study in Alzheimer's disease patients age 70 and over, the use of zinc as a potential dietary management for cognitive deficits in Alzheimer's patients, the limitations inherent in post-hoc interpretations of clinical study results, the size of the Alzheimer's population, our intent to further commercialize development of reaZin as a prescription medical food, the size and evaluation time of the anticipated clinical study and the expected results of the larger clinical study with regard to the loss of cognition. The forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those set forth or implied by any forward-looking statements. Important factors that could cause actual results to differ materially from those reflected in Adeona's forward-looking statements include, among others, our failure to successfully commercialize reaZin for the management of Alzheimer's disease, the failure of reaZin to be accepted for dietary management of Alzheimer's disease, failure of future clinical studies evaluating reaZin to have favorable results, and other factors described in Adeona's report on Form 10-K for the year ended December 31, 2010 and any other filings with the SEC. The information in this release is provided only as of the date of this release, and Adeona undertakes no obligation to update any forward-looking statements contained in this release on account of new information, future events, or otherwise, except as required by law.

SOURCE Adeona Pharmaceuticals, Inc.



See full article from DailyFinance: http://srph.it/mF6Qum

AEN is up 33% this morning.



The board of directors and management resumes are great too.




Adeona Announces Positive Alzheimer's Subgroup Analysis that Supports Additional Clinical Study of Proprietary Zinc-Based Therapy
PR Newswire
Posted 9:00 AM 06/02/11


ANN ARBOR, Mich., June 2, 2011 /PRNewswire/ -- Adeona Pharmaceuticals, Inc. (NYSE Amex: AEN), a developer of innovative medicines for serious central nervous system diseases, announced today positive findings based on further analyses from the clinical study evaluating reaZin along with near-term plans for its Alzheimer's disease program. After reviewing the statistical analysis with the Company's scientific advisors, Adeona intends to conduct another Alzheimer's disease clinical study to evaluate its proprietary zinc-based tablet in patients age 70 and over. In parallel, Adeona intends to make reaZin commercially available as a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease.

After presenting the top-line results in April from the clinical study evaluating reaZin that demonstrated, on average, that the cognitive function (as measured by three standardized cognitive tests) of the patients managed with reaZin remained relatively stable over six months, while the placebo group showed deterioration, Adeona conducted further analyses to determine if certain subgroups in the patient sample benefitted from reaZin more than others.

After analyzing a number of independent variables associated with the patients enrolled in the clinical study on a post-hoc basis, the strongest relationship was found to be between age and cognitive outcomes. Patients in the study ranged from 52 to 86 years of age. Patients in the placebo group, on average, showed age-related cognitive decline – the older the patient, the greater the rate of cognitive decline. In contrast, patients in the reaZin treatment group, on average, showed cognitive stabilization, no matter what their age. Therefore, the older the reaZin treatment patient, the greater the amount of cognitive benefit compared to the placebo patients of the same age.

These observations were supported by an age-related subgroup analysis that showed dosing-compliant patients age 70 and over (approximately the oldest three quartiles of the patients evaluable at the end of the study) demonstrated statistically significant improvements in two of the three cognitive scoring measurements in the reaZin treatment group compared to the placebo group. As presented below, in this subgroup, two of the three standard cognitive measures reached statistical significance (p < 0.05) as determined by the p-values (the average changes in cognitive scores from baseline to 6 months in the treatment group compared to the placebo group). The p-values were as follows:

?ADAS-Cog - Alzheimer's Disease Assessment Scale - Cognitive Subscale p-value: 0.037
?CDR-SOB - Clinical Dementia Rating Scale - Sum of Boxes p-value: 0.032
?MMSE - Mini Mental State Examination p-value: 0.067


Based upon the apparent cognitive benefit observed in these older patients who were managed with reaZin in comparison to patients who received the matching placebo, Adeona is preparing a larger clinical study protocol to evaluate patients diagnosed with mild to moderate Alzheimer's disease who are age 70 and over. It is anticipated that the clinical study will enroll over 100 patients and that the evaluation period will be at least 12 months. The intention is to develop the Company's proprietary zinc-based tablet as a drug (in parallel with making reaZin available as a prescription medical food) and to conduct this new clinical study under an Investigational New Drug (IND) application to be filed with the Food & Drug Administration (FDA).

"The biological availability of zinc is impaired in Alzheimer's disease as evidenced by significantly lower plasma zinc levels and deficiencies of neuronal zinc activities, each of which are further exacerbated with age. The recent clinical study of reaZin showed that the oral treatment is well-tolerated, and there are even trends to benefits in cognitive outcomes over the study period in several readouts. Based on the consistencies in these trends, the prevalence of abnormally low plasma zinc levels in the elderly, and the established detrimental effects of chronic zinc deficiency on cognition, I think it is very reasonable to test for the ability of reaZin to ameliorate cognitive decline in a larger-scale clinical trial," said Ashley I. Bush, M.D., Ph.D., Head of the Oxidation Disorders Laboratory for the Mental Health Research Institute, University of Melbourne and Adeona Scientific Advisory Board member.

"It is well documented that zinc deficiency increases as we age, and we as well as other clinical groups have shown that Alzheimer's patients are more zinc deficient in comparison to age-matched control patients. These observations support our belief that the older an Alzheimer's patient is, the more zinc depleted that patient is, and therefore, it is likely that patient will receive greater cognitive benefit when managed with our proprietary zinc-based tablet," said George J. Brewer, M.D., Senior Vice President of Adeona. "As we are currently witnessing an epidemic of Alzheimer's disease, such that well over 10 million Americans are affected, we are very excited to begin a larger clinical study intended to further demonstrate that reaZin is effective in preventing or slowing the loss of cognition in older Alzheimer's patients and therefore help stem the tide of this epidemic."

Top-Line Results from the Clinical Study Evaluating reaZin

The top-line results from Adeona's clinical study evaluating reaZin for the dietary management of zinc deficiency associated with Alzheimer's disease were presented at the 63rd Annual Meeting of the American Academy of Neurology in April 2011. As prospectively hypothesized, patients administered reaZin demonstrated increased serum zinc levels and decreased serum free copper levels, resulting in statistical significance of the primary outcomes of the clinical study (p < 0.0006). The cognitive function of the placebo group, on average, declined over 6 months in comparison to patients managed with reaZin. The cognitive function trends favoring the patients managed with reaZin were observed in all three standardized cognitive tests utilized in our study and suggest that reaZin may provide an important benefit to the dietary management of zinc deficiency associated with Alzheimer's disease.

About reaZin

reaZin is a proprietary, gastroretentive, sustained release, once-daily oral tablet formulated from zinc (150 mg) and cysteine (100 mg), an amino acid with potent anti-oxidant properties. reaZin was developed by Adeona to achieve the following: 1) the convenience of a once-daily dose, 2) high oral bioavailability (the quantity or fraction of the ingested dose that is absorbed by the body) and 3) superior tolerability which provides the ability to minimize the substantial gastrointestinal side effects and limitations associated with existing oral zinc therapy.

About Adeona Pharmaceuticals, Inc.

Adeona is a pharmaceutical company developing innovative medicines for the treatment of serious central nervous system diseases. The Company's primary strategy is to license product candidates that have demonstrated a certain level of clinical efficacy and develop them to a stage that results in a significant commercial collaboration. Currently, Adeona is developing, or has partnered the development of, the following product candidates: a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease, and drugs to treat multiple sclerosis, fibromyalgia, Alzheimer's disease and age-related macular degeneration. For more information, please visit Adeona's website at www.adeonapharma.com.

This release includes forward-looking statements on Adeona's current expectations and projections about future events. In some cases forward-looking statements can be identified by terminology such as "may,""could,""potential,""positions,""continue,""expects,""anticipates,""intends,""plans,""believe,""estimates," and similar expressions. These statements are based upon current beliefs, expectations and assumptions and are subject to a number of risks and uncertainties, many of which are difficult to predict and include statements regarding the plans to move our Alzheimer's disease development program forward, our intent to conduct another clinical study in Alzheimer's disease patients age 70 and over, the use of zinc as a potential dietary management for cognitive deficits in Alzheimer's patients, the limitations inherent in post-hoc interpretations of clinical study results, the size of the Alzheimer's population, our intent to further commercialize development of reaZin as a prescription medical food, the size and evaluation time of the anticipated clinical study and the expected results of the larger clinical study with regard to the loss of cognition. The forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those set forth or implied by any forward-looking statements. Important factors that could cause actual results to differ materially from those reflected in Adeona's forward-looking statements include, among others, our failure to successfully commercialize reaZin for the management of Alzheimer's disease, the failure of reaZin to be accepted for dietary management of Alzheimer's disease, failure of future clinical studies evaluating reaZin to have favorable results, and other factors described in Adeona's report on Form 10-K for the year ended December 31, 2010 and any other filings with the SEC. The information in this release is provided only as of the date of this release, and Adeona undertakes no obligation to update any forward-looking statements contained in this release on account of new information, future events, or otherwise, except as required by law.

SOURCE Adeona Pharmaceuticals, Inc.



See full article from DailyFinance: http://srph.it/mF6Qum

AEN is up 33% this morning.



The board of directors and management resumes are great too.




Adeona Announces Positive Alzheimer's Subgroup Analysis that Supports Additional Clinical Study of Proprietary Zinc-Based Therapy
PR Newswire
Posted 9:00 AM 06/02/11


ANN ARBOR, Mich., June 2, 2011 /PRNewswire/ -- Adeona Pharmaceuticals, Inc. (NYSE Amex: AEN), a developer of innovative medicines for serious central nervous system diseases, announced today positive findings based on further analyses from the clinical study evaluating reaZin along with near-term plans for its Alzheimer's disease program. After reviewing the statistical analysis with the Company's scientific advisors, Adeona intends to conduct another Alzheimer's disease clinical study to evaluate its proprietary zinc-based tablet in patients age 70 and over. In parallel, Adeona intends to make reaZin commercially available as a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease.

After presenting the top-line results in April from the clinical study evaluating reaZin that demonstrated, on average, that the cognitive function (as measured by three standardized cognitive tests) of the patients managed with reaZin remained relatively stable over six months, while the placebo group showed deterioration, Adeona conducted further analyses to determine if certain subgroups in the patient sample benefitted from reaZin more than others.

After analyzing a number of independent variables associated with the patients enrolled in the clinical study on a post-hoc basis, the strongest relationship was found to be between age and cognitive outcomes. Patients in the study ranged from 52 to 86 years of age. Patients in the placebo group, on average, showed age-related cognitive decline – the older the patient, the greater the rate of cognitive decline. In contrast, patients in the reaZin treatment group, on average, showed cognitive stabilization, no matter what their age. Therefore, the older the reaZin treatment patient, the greater the amount of cognitive benefit compared to the placebo patients of the same age.

These observations were supported by an age-related subgroup analysis that showed dosing-compliant patients age 70 and over (approximately the oldest three quartiles of the patients evaluable at the end of the study) demonstrated statistically significant improvements in two of the three cognitive scoring measurements in the reaZin treatment group compared to the placebo group. As presented below, in this subgroup, two of the three standard cognitive measures reached statistical significance (p < 0.05) as determined by the p-values (the average changes in cognitive scores from baseline to 6 months in the treatment group compared to the placebo group). The p-values were as follows:

?ADAS-Cog - Alzheimer's Disease Assessment Scale - Cognitive Subscale p-value: 0.037
?CDR-SOB - Clinical Dementia Rating Scale - Sum of Boxes p-value: 0.032
?MMSE - Mini Mental State Examination p-value: 0.067


Based upon the apparent cognitive benefit observed in these older patients who were managed with reaZin in comparison to patients who received the matching placebo, Adeona is preparing a larger clinical study protocol to evaluate patients diagnosed with mild to moderate Alzheimer's disease who are age 70 and over. It is anticipated that the clinical study will enroll over 100 patients and that the evaluation period will be at least 12 months. The intention is to develop the Company's proprietary zinc-based tablet as a drug (in parallel with making reaZin available as a prescription medical food) and to conduct this new clinical study under an Investigational New Drug (IND) application to be filed with the Food & Drug Administration (FDA).

"The biological availability of zinc is impaired in Alzheimer's disease as evidenced by significantly lower plasma zinc levels and deficiencies of neuronal zinc activities, each of which are further exacerbated with age. The recent clinical study of reaZin showed that the oral treatment is well-tolerated, and there are even trends to benefits in cognitive outcomes over the study period in several readouts. Based on the consistencies in these trends, the prevalence of abnormally low plasma zinc levels in the elderly, and the established detrimental effects of chronic zinc deficiency on cognition, I think it is very reasonable to test for the ability of reaZin to ameliorate cognitive decline in a larger-scale clinical trial," said Ashley I. Bush, M.D., Ph.D., Head of the Oxidation Disorders Laboratory for the Mental Health Research Institute, University of Melbourne and Adeona Scientific Advisory Board member.

"It is well documented that zinc deficiency increases as we age, and we as well as other clinical groups have shown that Alzheimer's patients are more zinc deficient in comparison to age-matched control patients. These observations support our belief that the older an Alzheimer's patient is, the more zinc depleted that patient is, and therefore, it is likely that patient will receive greater cognitive benefit when managed with our proprietary zinc-based tablet," said George J. Brewer, M.D., Senior Vice President of Adeona. "As we are currently witnessing an epidemic of Alzheimer's disease, such that well over 10 million Americans are affected, we are very excited to begin a larger clinical study intended to further demonstrate that reaZin is effective in preventing or slowing the loss of cognition in older Alzheimer's patients and therefore help stem the tide of this epidemic."

Top-Line Results from the Clinical Study Evaluating reaZin

The top-line results from Adeona's clinical study evaluating reaZin for the dietary management of zinc deficiency associated with Alzheimer's disease were presented at the 63rd Annual Meeting of the American Academy of Neurology in April 2011. As prospectively hypothesized, patients administered reaZin demonstrated increased serum zinc levels and decreased serum free copper levels, resulting in statistical significance of the primary outcomes of the clinical study (p < 0.0006). The cognitive function of the placebo group, on average, declined over 6 months in comparison to patients managed with reaZin. The cognitive function trends favoring the patients managed with reaZin were observed in all three standardized cognitive tests utilized in our study and suggest that reaZin may provide an important benefit to the dietary management of zinc deficiency associated with Alzheimer's disease.

About reaZin

reaZin is a proprietary, gastroretentive, sustained release, once-daily oral tablet formulated from zinc (150 mg) and cysteine (100 mg), an amino acid with potent anti-oxidant properties. reaZin was developed by Adeona to achieve the following: 1) the convenience of a once-daily dose, 2) high oral bioavailability (the quantity or fraction of the ingested dose that is absorbed by the body) and 3) superior tolerability which provides the ability to minimize the substantial gastrointestinal side effects and limitations associated with existing oral zinc therapy.

About Adeona Pharmaceuticals, Inc.

Adeona is a pharmaceutical company developing innovative medicines for the treatment of serious central nervous system diseases. The Company's primary strategy is to license product candidates that have demonstrated a certain level of clinical efficacy and develop them to a stage that results in a significant commercial collaboration. Currently, Adeona is developing, or has partnered the development of, the following product candidates: a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease, and drugs to treat multiple sclerosis, fibromyalgia, Alzheimer's disease and age-related macular degeneration. For more information, please visit Adeona's website at www.adeonapharma.com.

This release includes forward-looking statements on Adeona's current expectations and projections about future events. In some cases forward-looking statements can be identified by terminology such as "may,""could,""potential,""positions,""continue,""expects,""anticipates,""intends,""plans,""believe,""estimates," and similar expressions. These statements are based upon current beliefs, expectations and assumptions and are subject to a number of risks and uncertainties, many of which are difficult to predict and include statements regarding the plans to move our Alzheimer's disease development program forward, our intent to conduct another clinical study in Alzheimer's disease patients age 70 and over, the use of zinc as a potential dietary management for cognitive deficits in Alzheimer's patients, the limitations inherent in post-hoc interpretations of clinical study results, the size of the Alzheimer's population, our intent to further commercialize development of reaZin as a prescription medical food, the size and evaluation time of the anticipated clinical study and the expected results of the larger clinical study with regard to the loss of cognition. The forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those set forth or implied by any forward-looking statements. Important factors that could cause actual results to differ materially from those reflected in Adeona's forward-looking statements include, among others, our failure to successfully commercialize reaZin for the management of Alzheimer's disease, the failure of reaZin to be accepted for dietary management of Alzheimer's disease, failure of future clinical studies evaluating reaZin to have favorable results, and other factors described in Adeona's report on Form 10-K for the year ended December 31, 2010 and any other filings with the SEC. The information in this release is provided only as of the date of this release, and Adeona undertakes no obligation to update any forward-looking statements contained in this release on account of new information, future events, or otherwise, except as required by law.

SOURCE Adeona Pharmaceuticals, Inc.

Super News Today.


If interested, this is a press release from this morning about the company I was telling you about yesterday that's involved with an alzheimer treatment, and its positive progress regarding their current trial.

The board of directors and management resumes are really good.





Adeona Announces Positive Alzheimer's Subgroup Analysis that Supports Additional Clinical Study of Proprietary Zinc-Based Therapy
PR Newswire
Posted 9:00 AM 06/02/11


ANN ARBOR, Mich., June 2, 2011 /PRNewswire/ -- Adeona Pharmaceuticals, Inc. (NYSE Amex: AEN), a developer of innovative medicines for serious central nervous system diseases, announced today positive findings based on further analyses from the clinical study evaluating reaZin along with near-term plans for its Alzheimer's disease program. After reviewing the statistical analysis with the Company's scientific advisors, Adeona intends to conduct another Alzheimer's disease clinical study to evaluate its proprietary zinc-based tablet in patients age 70 and over. In parallel, Adeona intends to make reaZin commercially available as a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease.

After presenting the top-line results in April from the clinical study evaluating reaZin that demonstrated, on average, that the cognitive function (as measured by three standardized cognitive tests) of the patients managed with reaZin remained relatively stable over six months, while the placebo group showed deterioration, Adeona conducted further analyses to determine if certain subgroups in the patient sample benefitted from reaZin more than others.

After analyzing a number of independent variables associated with the patients enrolled in the clinical study on a post-hoc basis, the strongest relationship was found to be between age and cognitive outcomes. Patients in the study ranged from 52 to 86 years of age. Patients in the placebo group, on average, showed age-related cognitive decline – the older the patient, the greater the rate of cognitive decline. In contrast, patients in the reaZin treatment group, on average, showed cognitive stabilization, no matter what their age. Therefore, the older the reaZin treatment patient, the greater the amount of cognitive benefit compared to the placebo patients of the same age.

These observations were supported by an age-related subgroup analysis that showed dosing-compliant patients age 70 and over (approximately the oldest three quartiles of the patients evaluable at the end of the study) demonstrated statistically significant improvements in two of the three cognitive scoring measurements in the reaZin treatment group compared to the placebo group. As presented below, in this subgroup, two of the three standard cognitive measures reached statistical significance (p < 0.05) as determined by the p-values (the average changes in cognitive scores from baseline to 6 months in the treatment group compared to the placebo group). The p-values were as follows:

?ADAS-Cog - Alzheimer's Disease Assessment Scale - Cognitive Subscale p-value: 0.037
?CDR-SOB - Clinical Dementia Rating Scale - Sum of Boxes p-value: 0.032
?MMSE - Mini Mental State Examination p-value: 0.067


Based upon the apparent cognitive benefit observed in these older patients who were managed with reaZin in comparison to patients who received the matching placebo, Adeona is preparing a larger clinical study protocol to evaluate patients diagnosed with mild to moderate Alzheimer's disease who are age 70 and over. It is anticipated that the clinical study will enroll over 100 patients and that the evaluation period will be at least 12 months. The intention is to develop the Company's proprietary zinc-based tablet as a drug (in parallel with making reaZin available as a prescription medical food) and to conduct this new clinical study under an Investigational New Drug (IND) application to be filed with the Food & Drug Administration (FDA).

"The biological availability of zinc is impaired in Alzheimer's disease as evidenced by significantly lower plasma zinc levels and deficiencies of neuronal zinc activities, each of which are further exacerbated with age. The recent clinical study of reaZin showed that the oral treatment is well-tolerated, and there are even trends to benefits in cognitive outcomes over the study period in several readouts. Based on the consistencies in these trends, the prevalence of abnormally low plasma zinc levels in the elderly, and the established detrimental effects of chronic zinc deficiency on cognition, I think it is very reasonable to test for the ability of reaZin to ameliorate cognitive decline in a larger-scale clinical trial," said Ashley I. Bush, M.D., Ph.D., Head of the Oxidation Disorders Laboratory for the Mental Health Research Institute, University of Melbourne and Adeona Scientific Advisory Board member.

"It is well documented that zinc deficiency increases as we age, and we as well as other clinical groups have shown that Alzheimer's patients are more zinc deficient in comparison to age-matched control patients. These observations support our belief that the older an Alzheimer's patient is, the more zinc depleted that patient is, and therefore, it is likely that patient will receive greater cognitive benefit when managed with our proprietary zinc-based tablet," said George J. Brewer, M.D., Senior Vice President of Adeona. "As we are currently witnessing an epidemic of Alzheimer's disease, such that well over 10 million Americans are affected, we are very excited to begin a larger clinical study intended to further demonstrate that reaZin is effective in preventing or slowing the loss of cognition in older Alzheimer's patients and therefore help stem the tide of this epidemic."

Top-Line Results from the Clinical Study Evaluating reaZin

The top-line results from Adeona's clinical study evaluating reaZin for the dietary management of zinc deficiency associated with Alzheimer's disease were presented at the 63rd Annual Meeting of the American Academy of Neurology in April 2011. As prospectively hypothesized, patients administered reaZin demonstrated increased serum zinc levels and decreased serum free copper levels, resulting in statistical significance of the primary outcomes of the clinical study (p < 0.0006). The cognitive function of the placebo group, on average, declined over 6 months in comparison to patients managed with reaZin. The cognitive function trends favoring the patients managed with reaZin were observed in all three standardized cognitive tests utilized in our study and suggest that reaZin may provide an important benefit to the dietary management of zinc deficiency associated with Alzheimer's disease.

About reaZin

reaZin is a proprietary, gastroretentive, sustained release, once-daily oral tablet formulated from zinc (150 mg) and cysteine (100 mg), an amino acid with potent anti-oxidant properties. reaZin was developed by Adeona to achieve the following: 1) the convenience of a once-daily dose, 2) high oral bioavailability (the quantity or fraction of the ingested dose that is absorbed by the body) and 3) superior tolerability which provides the ability to minimize the substantial gastrointestinal side effects and limitations associated with existing oral zinc therapy.

About Adeona Pharmaceuticals, Inc.

Adeona is a pharmaceutical company developing innovative medicines for the treatment of serious central nervous system diseases. The Company's primary strategy is to license product candidates that have demonstrated a certain level of clinical efficacy and develop them to a stage that results in a significant commercial collaboration. Currently, Adeona is developing, or has partnered the development of, the following product candidates: a prescription medical food for the dietary management of zinc deficiency associated with Alzheimer's disease, and drugs to treat multiple sclerosis, fibromyalgia, Alzheimer's disease and age-related macular degeneration. For more information, please visit Adeona's website at www.adeonapharma.com.

This release includes forward-looking statements on Adeona's current expectations and projections about future events. In some cases forward-looking statements can be identified by terminology such as "may,""could,""potential,""positions,""continue,""expects,""anticipates,""intends,""plans,""believe,""estimates," and similar expressions. These statements are based upon current beliefs, expectations and assumptions and are subject to a number of risks and uncertainties, many of which are difficult to predict and include statements regarding the plans to move our Alzheimer's disease development program forward, our intent to conduct another clinical study in Alzheimer's disease patients age 70 and over, the use of zinc as a potential dietary management for cognitive deficits in Alzheimer's patients, the limitations inherent in post-hoc interpretations of clinical study results, the size of the Alzheimer's population, our intent to further commercialize development of reaZin as a prescription medical food, the size and evaluation time of the anticipated clinical study and the expected results of the larger clinical study with regard to the loss of cognition. The forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially from those set forth or implied by any forward-looking statements. Important factors that could cause actual results to differ materially from those reflected in Adeona's forward-looking statements include, among others, our failure to successfully commercialize reaZin for the management of Alzheimer's disease, the failure of reaZin to be accepted for dietary management of Alzheimer's disease, failure of future clinical studies evaluating reaZin to have favorable results, and other factors described in Adeona's report on Form 10-K for the year ended December 31, 2010 and any other filings with the SEC. The information in this release is provided only as of the date of this release, and Adeona undertakes no obligation to update any forward-looking statements contained in this release on account of new information, future events, or otherwise, except as required by law.

SOURCE Adeona Pharmaceuticals, Inc.

What a great idea if PK offered shareholders discounted rooms?

I would go. Montauk is terrific. It would be another good creative gorilla marketing idea ... though he probably is afraid to face us.

We've been hearing about the return of the Miss Rheingold contest; it's been years in the making and I'm still waiting.

I'm thinking it's going to happen on the back of a club deck somewhere in Montauk. That's like them participating in the St. Pat parade out there in March ... it made as much noise as a pin dropping. They need to get into NYC and the boroughs and promote Rheingold and the contest in the heart of their market.

so far there's no advertising the contest in the retail outlets or bars where Rheingold is being served. No posters announcing where people can enter. No pumping it on the web site where visitors can enter and vote. No slips of paper with an announcement being handed out at retail locations ... nothing, nada, zippo. It's June already. The summer consumption season has started. What are they waiting for. Rheingold was re-introduced during September 2010.

The contest could be huge, they could have been promoting it for 9 months already. It could involve thousands or more entrants, yet I think it's going to sound like a whisper.

Before you go ahead and say more votes have been cast than in presidential elections for Miss Rheingold, check out the counter on the web site for "Vote for the Rheingold Pigeon!" ... there's been "3360 total votes since 01/07/11"

That's what's happening at DKAM today.

Their web site is not current, and they are doing nothing to drive people to it. They're not even using the beer cases to advertise anything, and that costs them nothing except it's a lost opportunity.


Meanwhile, I'll be passing out Rheingold's tonight. Just doing my part.

Missouri is the "show me" state.

What "longs" see is a company that dug itself into a huge hole and isn't embarrassed at all to dig a little deeper. Missteps abounded, launch after launch.

PR's announce half the story. They're not lies. They're definitely truths, but they are deceiving and almost always accompanied by a share-dump.

I am most impressed that PK has managed to roll out Rheingold through so many distributors and into so many states. The distributors are willing to take on the product and push it into retail outlets. But no one can make consumers buy it.

Without consumer awareness and promotional advertising, it seems to me that the only growth is coming from new distributors. We are hoping existing distributors are reordering in larger quantities. But, there has been no PR noting it, and that would be something we would hear about ... in BIG BOLD ANNOUNCEMENTS.

As long as dilution remains a viable form of barter, DKAM will be around for a long time.

This news is only positive. We've been saying as recently as this past weekend that they needed to use press releases to publize the good things that are going on, and now they hired a company to do it. More people than the 10 who currently know about this company are going to learn about it real soon.

CUGI is doing so many things right, and this is another terrific step.

CUGI revenues jump 31% and they FINALLY hired a company to tell the story of this $40,000,000+ company.


CUI Global Engages Liolios Group to Lead New Investor Relations Program
Business Wire
Posted 5:30 AM 06/01/11


CUI Global, Inc. (OTCBB: CUGI), a platform company dedicated to the acquisition, development, and commercialization of new, innovative technologies, has engaged Liolios Group to lead its investor relations and financial communications program.

“We have now arrived at a pivotal stage in our development, making it important for a team of experienced professionals like Liolios Group to help us deliver our story to the investment community,” said William Clough, president and CEO of CUI Global.

“Our sales force is now expanded and our proven product lines have generated a 31% revenue increase in Q1 over last year,” said Clough. “We are preparing to release our Solus™ Topology and are gaining traction with GasPT2. We anticipate continued revenue growth from our existing product offering as well as from the introduction and commercialization of new and proprietary technologies. With this continued growth, we believe it is time to effectively communicate our opportunity to a broader range of the investment community.”

Liolios Group brings to CUI Global a proven track record of assisting emerging growth companies in positioning their message for maximum resonation within the financial community and building quality, long-term relationships with investors, analysts and institutions.

For additional information about CUI Global, contact Liolios Group at 949-574-3860 or e-mail: info@liolios.com.

About Liolios Group, Inc.

Liolios Group, Inc. is a highly selective and comprehensive investor relations firm specializing in small and micro-cap companies. The firm aims to deliver superior performance in corporate messaging and positioning, investor awareness, analyst and financial press coverage, and capital attraction. Founded in 1996 in Newport Beach, California, Liolios Group partners each have more than 15 years experience in finance and investments, and represent clients in a wide range of industries, including clean technology, consumer & retail, healthcare & bio-pharma, digital media & software, and technology. For more information about Liolios Group, please visit www.liolios.com.

About CUI Global, Inc.

CUI Global is a publicly traded platform company dedicated to maximizing shareholder value through the acquisition and development of innovative companies and technologies. From its GasPT2 platform targeting the energy sector, to its subsidiary CUI Inc.'s industry leading digital power platform targeting the networking and telecom industries, CUI Global has built a diversified portfolio of industry leading technologies that touch many markets. As a publicly traded company, shareholders are able to participate in the opportunities, revenues, and profits generated by the products, technologies, and market channels of CUI Global and its subsidiaries. CUI Global prides itself on operating with the same level of integrity, respect, and philanthropic dedication that was put in place by CUI Inc.’s founder more than 20 years ago. It is these values that allow the company to make a difference in the lives of their customers, their community, their employees, and their investors. Recently, a move was made to merge and streamline resources with its subsidiary CUI Inc. in order to create a unified, international brand that now positions CUI Global for further strategic expansion.

For more information, please visit www.cuiglobal.com and www.cui.com.

Important Cautions Regarding Forward Looking Statements

This document contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such statements are subject to risks and uncertainties that could cause actual results to vary materially from those projected in the forward-looking statements. The company may experience significant fluctuations in future operating results due to a number of economic, competitive, and other factors, including, among other things, our reliance on third-party manufacturers and suppliers, government agency budgetary and political constraints, new or increased competition, changes in market demand, and the performance or reliability of our products. These factors and others could cause operating results to vary significantly from those in prior periods, and those projected in forward-looking statements. Additional information with respect to these and other factors, which could materially affect the company and its operations, are included in certain forms the company has filed with the Securities and Exchange Commission.