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Care to provide facts of your glorious assumptions? Pluristem says a lot of things like they made most of their milestones. Whole first paragraph of their letter to shareholders was fictional, just like the tortoise and the hare. Show me an analyst that thinks that. Heck even Spidey disagreed. A whopping 14 sites remember, 26 shy of their 2017 goal. Remember that news release Pluristem put out?
LMBOx200,000. You know why.
Wrote the word options out of this exhibit from their latest filing with regards to the 2005 plan. Changed it to awards. Like always, they got sick of options expiring. Decided to gift people shares to "retain" them. It was good for the twins, so everyone else should share in the windfall too, just not shareholders. And our beloved board will decide as always, which employees will win the lottery. It's biotech!!!
https://www.sec.gov/Archives/edgar/data/1158780/000117891309000154/exhibit_10-1.htm
What's your point. Sagi get the boot or promotion? We going to get your triplet prediction any day? Another stellar resume joined the company. Sheesh. I must have missed that news release touting the big industry veteran coming on board. Maybe THAT was one of their "surprise milestones made". Maybe they kept it a surprise for a reason. Didn't want anyone to see
Or did Sagi leave for Lonza. Did Lonza demand some of the top personnel from Pluristem before the deal gets done. They're dying to get Pluristem as a customer aren't they..
If the shoe fits for the circus of clowns at Pluristem, so be it. All talk and zero show buys nothing but a pathetic share price. Does that fit the bill? Comments with facts to back them up aren't really defamatory are they?
Information... LMBOx200,000. You know why
Already mentioned that thanks. So again no takers as it was too close to home and not exotic enough. Arik drew the short straw. Or are they sending the Director of Homeland Security to this show because of the ever increased potential of a diabetic army attacking the world is concerned about. Lots of military will be in attendance I heard.
Yes they said it so it must be true. We didn't lose out on manufacturing so why would we lose out to competition in products. Can't happen. Our price clearly shows the realists on this board are wrong, and the volume does as well.
No valid points on the contrarian side. Nope. Just can't be. Funny how everyone avoids all of those points huh. So I will leave off with my normal saying, I'm sure you know why.
LMBOx200,000
Good article on the cost of car-t therapy. With an actual link can you believe it? I tend to think actual articles carry a little more weight than someone's posts.
Sure the cost may be huge now, but people will figure out a way to make it more widely available. Just like manufacturing cells for commercial quantities. Seems like this may be a goal of Celularity. Don't they already operate cell banks? Moving to allogeneic therapy? The placenta? But they're years behind us. No worries at all right.
"When it comes to improving access, one of the approaches being studied is the use of universal cell banks as opposed to autologous cells for therapy. This “off-the-shelf” approach, much like the approach used in transfusion medicine, would allow for quicker availability of the cells to a greater number of patients, she said."
https://www.mdedge.com/hematologynews/article/152563/all-acute-lymphoblastic-leukemia/car-t-cell-therapy-moving-cost-value
So right EichKing. Some here just want to copy things to try and make it sound like they have some sort of knowledge. Would be more credible if they actually posted the links to where they found things. Same with bragging about a billion share goal. Thinks it gives credibility. Doesn't to anyone without blinders on.
Competition is everywhere. Yes we are in a new era in the treatment of many different diseases We are up against behemoths with deep pockets and management with vast experience and knowledge in the industry. Know what markets to attack first. How to bring in other accomplished industry veterans to help them achieve their goals. Experienced in the complicated world of clinical trials, FDA, manufacturing, everything. Connections DO go a long way. Not ones you have a drink with at a trade show, but people you have actually met with in real boardrooms with real discussions. Some here are making the same mistake management has made for years, discounting the competition. Will be the death of them if they continue.
Do you really think people are going to pony up $250 million for a strategy that has little to no hope? Even if it is a long shot, which I highly doubt it is, see how experienced people were able to raise that amount in a heartbeat. It's called credibility. Elbit Vision System discards, don't have that clout sorry.
People overlook who runs this thing like nothing else I have ever seen. No concern at all. They are fine. Ahhhhh we lost manufacturing. Who cares. We still have our long drawn out trials. Investors still believe what quackies tell us since their credibility is still huge. Who cares if the CEO comes out and says they made most of their milestones. Truly does make you wonder if they made the requirements too difficult to attain good enrolment, in order to increase their odds of success.
But let's not address ANY one of these concerns. Not a single one by some. Just pretend they don't exist and if someone directly asks you, just pretend you didn't see it. Copy and paste when things look gloomy. Some questions have no good answers. Just ones that people want to ignore, as it takes them out of their happy places and makes them realize their investment isn't sitting so pretty. Can't argue facts. A very limited few try, some ignore, and some just flat out make things up.
Yes I always forget about that one. Shares. Guess that's what inexperienced management thinks are products they sell. Best 3d manufacturer of shares in the world. Probably one of their patents pending.
So what product do they have to sell? Funny how that wasn't directed to you. Keep flaunting what you do.
Wow where have I heard that before. You have to make it to the finish line before margins even come into play. No product, no margins so an emphatic NO, it's not all about margins.
We cut out the manufacturer. Margins will be bigger because of that if we ever do make it. Nothing to do with ours being able to produce cheaper. But those margins will shrink as manufacturing competition ramps us, and costs come down because of this.
People that try to bury factual posts are out in full force today right Blue. Among other methods. Too hard to face the truth that we have incompetent and inexperienced mangement in every way.
But you take zero consideration as to where this info is coming from. They miss a majority of their milestones yet somehow the head clown comes out and states they made most. Do you think that shows credibility. Does that make investors feel confident that what they say will happen, let alone at the fictitious time frames they attach to them? It's just Biotech right.
Words are NOT facts, especially when it comes to who is saying them. The delay in IC trial, was FACTUAL. Where is the data that was supposed to come in first half of 2017? These delays are FACTUAL. But maybe this time they will be right. More a chance of you being right for once.
And instead of looking for "additional data to support FUTURE milestones", they should work on current ones. The ones they are 7 months plus being late on. LMBO
But we don't, so we can only go on FACTS. You know what that word means right. Why stop at 60. Maybe the 4 German sites have enrolled 120? Your posts are only based on assumptions and hopes, with little to no known FACTS. Didn't want to comment on the one still not recruiting and how you were wrong on that? Called someone clueless but who was actually clueless.
There was an article posted recently of a Phase 2 that looked promising. The the phase 3 didn't support the results though. That's why Phase 3 trials knock out a large proportion of candidates. We are jumping from Phase 1 numbers to 3, so that challenge will be harder. A comment from an investigator like that is positive yes, but can't be taken to the heights some here hope to. Hints it MAY work, is just that...may work. Long way to go to see if it DOES work. Years most likely.
You know that is not true but yet you want to mislead. You know the one site has been not yet recruiting for a long time and still is. But ohhhhhh. Ahhhhhhh Thanks Allo.
When should we expect them to reach the goal of 40 sites? 2019 or 2020. They said it in September of last year, so by gauging on past performance, I will say indefinitely. But any month now we should get approval.
Yes from way back in 2014. Someone may have wanted to check out the legitimacy of the patent, and once denied, moved on to figuring it out in a different way that avoids infringement. Which from my posts from last night seem to confirm with regards to figuring it out. But yet again, "WE" are trying for "denial in service" and trying to bury posts. Jokes.
Replies to Allo's 3 posts.
Post 1
Taken from 2015 letter to shareholders. Talk is cheap. They've been rehashing the same thing, just like some here. Talk is cheap and we still have no new partners to speak of. But they've been saying this for much longer.
Pluristem continues working to establish additional business collaborations with pharmaceutical companies. The new opportunities in Europe and Japan have translated into substantial interest from potential partners who would like to work together with us in both geographic regions
http://www.pluristem.com/wp-content/uploads/2016/05/Pluristem-CEO-Letter-May-25-Final.pdf
Post 2.
They have "treated" a little over 200. But have only seen results on 50 at most. And again, without statistical evidence. They can "treat" a thousand but without results, pointless.
Post 3
This was taken in July of 2016. Initial results were announce Feb 2, 2015. Another delay delay delay. They talk always but NEVER deliver. Three years and counting for phase 3 to start since phase 1 was done.
Pluristem Advances Towards Multinational Phase III Trial of PLX-PAD to Improve Recovery Following Surgery for Hip Fracture
But yet some claim we are trying to implement a "denial of service". Look no farther than these 3 separate posts of useless info that shows nothing but how horrible this company is run and the never ending delays. Seems like someone is trying to bury posts about manufacturing don't you think? But at least they attempt rebuttals. Key word being attemp. Absolute jokes.
Seems to be the norm on this board right EichKing. Just ignore facts and pretend those questions don't exist. Way too many here doing the same thing. Blinders R us. Kind of makes you go hmmmmm. What ever happened to Butteo eh? They used to pop in once in a while to throw their "expert" points into the mix. Seems like someone took over that role.
16,000 shares. Interest is picking up.
Denial of service? LMBO.
Should I not respond to an attempt to discredit to say we have a monopoly when we clearly don't. When a poster keeps coming back with other made up facts, should I not respond to show the errors, in fear that I am posting too much?
What engagement of responses to the many questions brought up are you talking about. The only ones who don't respond are the ones that are in denial to what this company is really about.
Have I heard responses of the true risks of this company? Nope. Just "there are risks"
Have I heard responses to the questionable resumes of management and board? Nope
Have I heard responses to Zami's gaff of saying we made most milestones? Nope.
Have I heard any responses to our manufacturing edge that has been lost over the years? Only one attempt that was shot down.
Have I heard responses to the fact that we have NO statistically evident data in any human trial. We are a phase 1 company jumping to phase 3. That's why investors don't care that we are a phase 3 company. And that's why that question of show me another company in Phase 3 bears no point. Edison report clearly stated that in the risks. And again, nope.
So the only ones who aren't engaging are the believers in this company. It's pretty obvious why, as there's little to no argument. But when people try to state otherwise, I will bring up evidence that backs up MY argument.
And as far as the TOS in this board. Who gets their posts deleted pretty much every day, and we may get an edited version of it later. Please don't call the kettle back. Please engage in the arguments. Maybe your posts will be seen by everyone.
Just keep hoping we will go away right. Perfect examples of my argument in the posts this morning don't you think? Yes just skip over as one suggests.
And even Pluristem took the mention of Petri dishes off their presentations finally. Wonder why.
You are correct there. What or how other companies manufacture has "nothing to do with Pluristem's patents" like you say. We will still have those patents don't you worry
Not saying OUT DO, just an ability to manufacture to scale, and at a cost most likely to be in line with ours. This is my assumption. Allo would have one believe they still grow in petri dishes.
Would still be in control of the manufacturing making for higher margins. But they blew it on this. I'm sorry if you don't want to see it or believe it. Can't make some believe no matter what.
Birds of a feather...
Glad you find what you dream up a joke. Didn't think you'd reply with any factual information. Why start now. But many here are under water and have lost money from what management has done. Glad your ok with it. You're in the anything under $2 is a steal camp as well right.
Like always, it's just too easy. And it's not just one but a team of workers.
I'm honoured you even attempted to answer my question in the first place. Normally you just avoid. Probably should have here too, but others can decide on that.
Of course this will be your last post to me. Can only make stuff up for so long. Sorry I burst your bubble when it comes to manufacturing. Funny I had said this before and you threw out some terms and things so I left it at that. This time I did a little DD on the subject, and proved what I had thought for quite some time.
Like I said yes they can grow the cells. Yes they grow them in 3d bioreactors. Yes they have patens to protect the manufacturing of these cells in a 3d bioreactor. Yes they have patents to protect using these 3d grown cells for a number of disease.
What I have SHOWN to you, is that others manufacture in bioreactors. See. No 3d. Therefore, no patent infringement. Competition has found other novel ways to manufacture these cells without infringing on patents. Go figure...competition doesn't stand still. Or are we to expect Pluristem to take on GE, Sartorius, Thermo Scientific among others in a patent infringement case?
What part of this are you not seeing? I've given you proof and you even admitted "only up to 50L". But they got stuck there right. Why would there be 1000 L or 2000 L bioreactors if the size doesn't matter? You were finally staring to understand, but then went back to denial with a weak, if not made up argument. Why don't you post the link to Pluristems website again to try and make your point like you did earlier. Just don't call me names so everyone will get a chance to see your entire argument, a webpage from Pluristem.
Do yourself a favour and not respond like you normally do to my questions. Try and save some face. Sorry I've shredded your hopes of a Lonza partnership to pieces.
Our share price is here for a reason. Just one piece to the puzzle. Controller is NOT a piece. Sometimes reality sucks huh.
Again, it's just too easy!!!
Is anyone else willing to come to Allo's defense? Zzatt, Spidey, Saud, MC, Jack, Happy...anybody??? You like to throw fancy terms out there Zzatt. What's your opinion.
Yes Pluristem can grow them. Never said they couldn't. They've been saying this for over a decade. A decade!!! How others can grow them now too is the question in hand. I like to look outside Pluristem. That's where you see the truth.. I make the best lasagna. Wouldn't some outside references be better than my own opinion? So care to try again. I have 3 more posts today so your strategy may just work for a couple hours.
I'm sure you'll see the praise like always don't you worry. Ohhhhhh Ahhhhhh. Pretty safe bet on that one.
It's just way too easy!!!
And try to reply to this Allo if you dare. Try not to use too many umms.
Here's another link to a published article in 2016 on growing human mesenchymal stem/stromal cells. The same cells we are growing. But we can rest on our laurels since what, 2005. Great job Zami. Jokes
Keep it to ourselves. Best invention ever!!! Nobody will ever figure out how to manufacture cells like we have. Like i said before, biggest gaff this company made. Missed the boat in a big way, and no way they could try to compete with the big boys who saw this need and stepped right over us.
But let's keep going to manufacturing shows to show off what we don't sell, and watch others that do. I'm sure the fight for the top is fast and furious with innovative solutions, leaving us holding our patents. They're probably worth millions right? Cmon Allo. Can't wait to hear what you dream up to counter this post.
https://www.sciencedirect.com/science/article/pii/S1369703X15300413
At the very least, look down to the table that shows the products available. Shows 500L to 2000L bioreactors among others.
Biostat from Sartorius (who partnered with Lonza in 2012 and have zero need for Pluristems reactor) but but but...they're opening in Haifa. Jokes.
Excellerex from GE
Hyperforma from Thermo Scientific.
I rest my case unless the chosen one wants more examples. Easily found this and others to provide factual evidence of my argument. I challenge Allo to just point us to one link that corroborates any part of the jibberish that was posted as a counter to my argument. Or even Zzatt can give it a try. Or are you in concurrence that others can grow these cells efficiently now too. Let's see what you come up with. Saud, Jack,Spidey. Dog, MC? Feel free to weigh in.
But I'm "ok" with management and the declining share price. Anything under a $2 is a steal right.
I know Blue. Just like to show how much stuff gets made up here. And the ones who BELIEB it. Monopoly. Jokes.
Monoclonal Antibodies, um I mean cells, err ok only in 50L bioreactors, err your right.... Um the collateral movement in the profusion/valve stem assembly, along with the turbo dynamic thingamabob, limits the 1000L bioreactor from growing anything else other than what I say. Or something like that. Did I just make that up? LMBO
Nice counter argument Hoping I run out of posting room.
Really any type of cell. I'm sure they can grow them in reactors. But the article was talking about stem cells. What type of cell are you going to attempt to counter with. Face it, manufacturing has figured it out. Whether you want to face it or not. Big opportunity brings about innovation. This space will be huge, too bad Pluristem didn't have the foresight to see it. They did at one point, but lost their way and kept it to themselves.
Your whole monopoly theory, shot down in one foul swoop. But you would think that someone who want to talk the talk would know about it. Just like the point you were incorrect on on how the 3d biorectors were only able to grow mesenchemyl stromal cells.
You've obviously relinquished your argument that bioreactors can't grow these types of cells. A start good job.
But don't you think in 5 years, they made the leap to bigger bioreactors. Or are they stuck at 50L max. They progerss on the difficult world of qubits. But nobody can leap past a 50L biorector.
Keep telling yourself that. Doesn't make it true. This article is from 2013, but it disproves your point. But yes we have the MONOPOLY. Maybe the board game to keep the employees happy.
"We are no longer growing stem cells in flat petri dishes or in bags. But in three to fifty liter bioreactors."
http://www.magazine.emerck/darmstadt_germany/innovation/stem_cell_initiative/Stem_cells_from_bioreactors1.html
Yes quite original and quite the knee slapper!!!
Yes a ton of patents for growing and curing things from cells made in a 3d bioreactor. Hate to break it to you but there are 1000L plus bioreactors out there. Without the 3d. Don't think they're making these things to conveniently stack Petri dishes.
Lonza partnered with Sartorius back in 2012. They have a 1000L biorector.
Pluristem missed the boat. Had a chance to beat out the competition on the manufacturing side. Took the wrong route. And like I pointed out, they can grow other cells besides MSC's.
And besides, do you think the competition is concerned about Pluristem's patents. Do you actually think they have the cash OR the time to fight an infringement case? They're pretty cheap and fast, last I heard.
Too bad we're not one of them. But unfortunately only management and you think they are.
Yes so funny. When is Zami's scheduled to appear on CNBC? Imagine that clown on there? We choose to sell right now via our ATM for $500 grand at a time. Kills all our feeble attempts at a rally. Yes we made all our milestones. We have an increased interest in partnerships. We made an accountant our co-ceo. The list would be never ending. Probably better we stay a "secret". No the title twins are for our clowns only. Saud. They earned it and our price proves it. Again, originality. Too many just follow. What's the word for that?
Those that dismiss the competition will fall to the competition. We dismissed them years ago.
I'm "ok" to be down on my investment.
Oh my great post thank you. They will never be able to do that raise since we own that space. I guess they didn't get the memo.
Pathetic is so fitting in so many ways.
You would think after all the shows they have done year after year, there would be some interest. Nope!!! Maybe the controller is sending delegates to any show Pluristem does to bad mouth them while they go off to the bathroom. Their reach is beyond reason, so you never know.
Maybe they should send the Director of Homeland Security to the diabetic event later this month. Oh, they are. Seems appropriate to send him there as his title fits the event. Or are we going to see more promotions? Nobody else available, or was it just wasn't exotic enough as its in Tel Aviv, and Arik drew the short straw.
Could in not be that people know any rise in price, could be a precursor to a raise to eliminate the run?
Could it not be that people realize Pluristem just might be selling into any rally like they have been?
Could it be people just don't like who's running the company and they're forever missed milestones? Or the fictitious statement on making these milestones that leads to a significant loss of credibility and belief this company's management is delusional? Or were his fingers crossed. Or did he mean 2018 as he said "this year," even though they were talking about last year. Just covering all the bases.
Nah!!! It's got to be the controller.
Partnerships are the only thing with less interest than our shares.
Well the time has come for this ever fitting sentence. We'll get em next week. And of course, LMBOx200,000-195,000. Try to be original eh, instead of always following what others say. Even if it only up for a very short time. Or the edited version which doesn't carry the feeble attempt at humour.
P.s. Tinder should really look into advertising in this board with all the ohhhhhs and ahhhhssss.
No the Japanese man in our presentation when he met the twins.
Thanks EichKing. Yes honesty goes a long way with credibility. Of all the things that are brought up about the circus we have running this company, NOBODY comes up with any valid points to state otherwise. Why? Because there aren't any valid arguments to counter. Just "it's biotech" or "show me another company..." I like to use factual evidence to back up my claims. That's why I sometimes use things that came straight from the horses mouth for evidence. Stuff that's not due to enrolment or ethics. Stuff that is in the incompetent one's own hands. Nobody else to blame or will someone dream up an excuse. How many excuses can there be. Waiting for "the dog ate the results" to come any day.
But then all the oooohs and awwwws come out. My unanswered questions from last night sure shows the lack of quality and credibility to some of the stuff that gets made up. Absolutely ridiculous, fictitious, baseless, and laughable points. Again, probably just the long arms of the controller. The excuse for everything that's wrong with this pathetic stock.
But we are clueless. LMBOx200,000-195,000
Pluristem Advances its Multinational Phase III Critical Limb Ischemia Study, Targeting Initiation at 40 Active Sites by the End of 2017
Can you believe they issued a press release in July of last year JUST for this? They really like to promote their epic fails.
Last updated on Clinical Trials website on Jan 9th. Only 15 sites listed with one not recruiting yet. Fell a little short of their goal don't you think? Didn't even make it to half of their goal of opening sites. Is there ANYTHING this company says and actually attains? No factual evidence here of the incompetence of management huh?
No lost credibility here or on any of their misses. Street must love the constant misses, and then to have the original twin make things up by saying they made most of their milestones. They love deception. Probably just the controller hindering the opening of the sites. Or ethical reasons why sites aren't opening. I've sometimes heard of it taking a year to open a site for this reason.
But yet somehow people here still think we will get interim results in CLI by 1h19. Even the company has taken the milestone of 2h18 to 1h19 out of all their material. Last we saw of that was from the January 2017 presentation.
Kind of makes you wonder why they expanded the trial to compassionate use. Study started May 22 of last year. We going to have the long painful recruitment like we did in IC?
Price and volume in our stock is progressing about as well as our supposed partnering interest coming from Asia that Zami's been touting for years now. It's in our 12 month milestone goal. Should change it to decade so we actually have a shot.
But I'm "ok" with them. LMBOx200,000. (Can't even be original there eh) Really should change that to LMBOx200,000-195,000 to be more realistic. But 200,000 is what makes some think their credibility becomes greater. But we have seen what has happened with the twins credibility when they make stuff up.
To Allo.
Do you still think anything under $2 is a gift like you said in post 7737. Funny how a lot of people here have said that don't you think. Wouldn't it be better now? But I'm clueless. Don't know how you'd describe your own posts. That's the best part about IH. Can't delete your posts
"Gift At Any Price Below $2.00"
To Allo.
And lastly I refer you back to post 7353 on Oct 19th. You never did answer me as to why you think this is the case. Was this to counter the controller. Was PLURISTEM selling in the dark pools? Maybe they are so none of the 3 firms they use are known. Pluristem IS the controller. LMBO
"It Looks Like Pluristem Wants The ATM Selling To Keep The Price At $ 1.80 ! "
To Allo
So remind me how Pluristem is going to become a Lonza customer as you say here in post 7443. There's another one below.
"Wow! Why Do You Make Things Up ? I Never Said Lonza Is Going To 3-D Expand MSC'S... I Said Pluristem is Going To Become A Lonza CUSTOMER ! Do You Have Any Idea What That Means ? Man, You Are Clueless About Lonza's Business Model. I'm Done With You Scotty, Time For You To Get Beamed Back-Up To Planet Prozac ! "
Or when do you think it will happen as December has come and gone. You were so confident in post 7441.
"Okay, I Will Say This Very Slowly...Pay Attention !
Pluristem's 5-Year Research Agreement Expires With The Charite' In Germany On December 31, 2017. On January 1st 2018 Pluristem No Longer Has A Collaboration Partner Right ! Okay, Lonza Has Their Own R&D Program That Is There For Their "CUSTOMERS" Pluristem IMO Is Going To Become A Lonza CUSTOMER And Possible A JV/Partner ?
IMO..Pluristem Management Decided, Since We Need Lonza For Our Global Build-Out For Our 3-D PLX-Cell Expansion Facilities, Why Not Form A Joint Venture With Lonza ? Even Better, Why Not Have Them Develop An R&D Facility About a 3 Minute Drive From Our Existing Facility And Staff It With Top-Notch Israeli Scientists.
That Way We Don't Have To Fly To Germany Anymore And Can Make R&D Decisions On-Site !
It's Just Too Much Of A Coincidence In My Mind, That Lonza's New Haifa R&D Facility Is Coming On-Line In December, Just As Pluristem Needs A New R&D Collaboration Partner ! Scott999, If This Plays Out The Way I Think It Is Going To Play Out. Pluristem Becomes A Global Customer Of Lonza, Leasing Space In Their Global Facilities... Lonza Becomes A JV/Partner In R&D And Most Likely Global Distibution Of PLX-Cells.
It's Also Possible That Lonza And Pluristem Become Their Own "Big Pharma" And Develop All Future Products Themselves And Distributing Them To Hospital Across The Globe, Thus Eliminating And Need For Future Big Pharma Licensing Deals ! If That Is What Eventually Happens IMO Big Pharma Is Going To Do The LA-FREAK, And Realize They Were Fools For Not Doing A Deal With Pluristem When They Had The Chance, By Waiting They Blew-It BIG-TIME BETTY ! GET READY ! Allo.. Be Thy Name. "